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Effects of puromycin on rat embryos in vitro

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Summary

Somite-staged rat embryos were exposed to varying concentrations of puromycin for 48 h in vitro. Medium concentrations below 0.92 μM had no significant effects, while concentrations above 1.84 μM were lethal. Between these extremes, there were concentration dependent increases in the incidence of malformations in a close relationship to growth retardation.

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Authors and Affiliations

  1. Division of Toxicology, Food and Drug Administration, 20204, Washington, D.C., USA

    T. J. Flynn, L. Friedman & T. N. Black

Authors
  1. T. J. Flynn
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  2. L. Friedman
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  3. T. N. Black
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Flynn, T.J., Friedman, L. & Black, T.N. Effects of puromycin on rat embryos in vitro. Experientia 43, 433–435 (1987). https://doi.org/10.1007/BF01940442

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  • DOI: https://doi.org/10.1007/BF01940442

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