Summary
The effects of forskolin on myenteric neuronal activity and mucosal function were examined in guinea pig ileum. Forskolin increased the excitability of myenteric neurons, and increased mucosal chloride secretion by stimulating enteric neurons as well as by acting directly on enterocytes.
References
Bhat, S. V., Bajwa, B. S., Dornauer, H., and de Souza, N. J., Tetrahedron Lett.19 (1977) 1669.
Seamon, K. B., Padgett, W., and Daly, J. W., Proc. natn. Acad. Sci. USA78 (1981) 3363.
Bridges, R. J., Rummel, W., and Simon, B., Naunyn-Schmiedebergs Arch. Pharmak.323 (1983) 355.
Binder, H. J., in: Physiology of the Gastrointestinal Tract, vol. 2, p. 1003. Ed. L. R. Johnson, Raven Press, New York 1981.
Field, M., in: Physiology of the Gastrointestinal Tract, vol. 2, p. 963. Ed. L. R. Johnson. Raven Press, New York 1981.
Furness, J.B., and Costa, M., Neuroscience5 (1980) 1.
Cooke, H.J., Am. J. Physiol.246 (1984) G263.
Cooke, H.J., Shonnard, K., and Wood, J.D., Am. J. Physiol.245 (1983) G290.
Wood, J.D., and Mayer, C.J., Pflügers Arch.374 (1978) 265.
Suprenant, A., J. Physiol., Lond.351 (1984) 343.
Wood, J.D., and Mayer, C.J., Nature, Lond.276 (1979) 836.
Katayama, Y., and North, R. A., Nature, Lond.274 (1978) 387.
Kilmer, S.L., and Carlsen, R.C., Nature, Lond.307 (1984) 455.
Author information
Authors and Affiliations
Additional information
Acknowledgment. The authors thank E. Martens, S. Bowen for technical assistance and N. Schaad for secretarial assistance. This work was supported by National Institutes of Health Grants, F32-AM07301, K-104-AM1004, RO1-AM29699, RO1-AM26742 and an Eloise Gerry Fellowship.
Rights and permissions
About this article
Cite this article
Carey, H.V., Cooke, H.J., Nemeth, P.R. et al. Nerve-mediated action of forskolin on guinea pig ileal mucosa. Experientia 41, 1156–1158 (1985). https://doi.org/10.1007/BF01951705
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01951705