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Effects of methylene blue on electrical behavior of myenteric neurons

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Summary

Intracellular recording methods were used to investigate the action of methylene blue on electrical behavior of myenteric neurons in guinea pig small intestine. The neurophysiological studies were done in parallel with studies on contractile activity of the intestinal musculature. Methylene blue depolarized the membranes, increased the input resistance, augmented excitability and reduced postspike hyperpolarizing potentials in AH/Type 2 myenteric neurons. These effects, with the exception of suppression of postspike hyperpolarization, were reversed by exposure to elevated calcium. The mechanism of action of methylene blue appeared to be suppression of calcium-dependent potassium conductance in the neuronal membranes. The neuronal action of methylene blue was manifest as a release of excitatory neurontransmitter substances with evoked contraction of the small intestinal longitudinal muscle.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, University of Nevada, 89557, Reno, Nevada, USA

    P. R. Nemeth, K. Daly, S. Erde & J. D. Wood

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  1. P. R. Nemeth
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  2. K. Daly
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  3. S. Erde
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  4. J. D. Wood
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Nemeth, P.R., Daly, K., Erde, S. et al. Effects of methylene blue on electrical behavior of myenteric neurons. Experientia 41, 259–261 (1985). https://doi.org/10.1007/BF02002626

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