Summary
Both acute and chronic administration of morphine resulted in an increase in the percent cardiac output received by brain. However, various brain regions were affected differently by the drug treatments. The greatest increases in percent cardiac output received after chronic administration of morphine occurred in pons and cerebellum, while the greatest increases after acute administration occurred in cortex and midbrain. The changes found are in contrast with earlier studies which suggest that morphine has no effect on cerebral blood flow.
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This work was supported by Chicago Heart Association grant No. C82-13 and BRSG 82508.
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Law, W.R., Ritzmann, R.F., Lee, J.M. et al. The effects of acute and chronic morphine on regional distribution of cardiac output in brain. Experientia 41, 78–80 (1985). https://doi.org/10.1007/BF02005885
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DOI: https://doi.org/10.1007/BF02005885