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Changes with hypertension and maturation in the response of stomach fundus to acetylcholine

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  • Physiology, Pathophysiology
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Summary

The purpose of these experiments was to compare the contractile response to ACh of stomach fundal strips from hypertensive (SHR) and normotensive (WKY) rats during the development of hypertension. The results indicate that the reactivity to ACh is the same in fundal strips from young SHR and WKY rats; however, with maturation strips from WKY rats undergo a reduction in responsiveness which does not occur in the SHR. Therefore, strips from older SHR rats are more reactive to ACh than are those from age matched WKY rats.

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Authors and Affiliations

  1. Department of Medicine, Section of Cardiovascular Sciences, and Section of Gastroenterology, Baylor College of Medicine, 77030, Houston, Texas, USA

    C. L. Seidel, J. C. Allen & A. Mukhopadhyay

Authors
  1. C. L. Seidel
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  2. J. C. Allen
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  3. A. Mukhopadhyay
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Additional information

Acknowledgment. The authors wish to acknowledge the assistance of Mark Kunneman and Elaine Hughes. This work was supported by the following grants: American Heart Association (Texas Affiliate) and National Institutes of Health HL 23815, HL 25349 and HL 24585.

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Seidel, C.L., Allen, J.C. & Mukhopadhyay, A. Changes with hypertension and maturation in the response of stomach fundus to acetylcholine. Experientia 40, 691–692 (1984). https://doi.org/10.1007/BF01949725

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  • DOI: https://doi.org/10.1007/BF01949725

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