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Reversible impairment of hepatobiliary function induced by streptozotocin in the rat

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The effect of streptozotocin (SZ) on hepatobiliary function was studied in rats on the 1st, 7th and 15th days of treatment. Serum glucose increased significantly on the 1st day, and then remained high. Bile flow, bile acids output and BSP biliary excretion were significantly decreased on the 1st day of treatment, whereas serum sorbitol dehydrogenase was increased. All the parameters tested apart from serum glucose tended to normalize with time. The results suggested a transient toxic effect of SZ on the hepatocyte.

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Authors and Affiliations

  1. Instituto de Fisiologia Experimental, Consejo Nacional de Investigaciones, Cientificas y Tecnicas (CONICET), Universidad Nacional de Rosario, Suipacha 570, 2000, Rosario, Argentina

    C. E. Carnovale & E. A. Rodriguez Garay

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  1. C. E. Carnovale
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  2. E. A. Rodriguez Garay
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Acknowledgment. This study was supported by a Research Grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), República Argentina. Joaquín V. Rodriguez is gratefully acknowledged for doing the chromatographic analyses of sulfobromophthalein, José M. Pellegrino for performing bile acids determination, and Mr. Raúl A. Trbojevich for surgical assistance.

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Carnovale, C.E., Garay, E.A.R. Reversible impairment of hepatobiliary function induced by streptozotocin in the rat. Experientia 40, 248–250 (1984). https://doi.org/10.1007/BF01947564

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