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The inhibitory amino acid GABA hyperpolarizes motor axons: an intracellular study

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Summary

The inhibitory amino acid γ-aminobutyric acid (GABA) hyperpolarized motor axons. This hyperpolarization was associated with an increase in the resting input conductance and with reduced action potential duration.

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References

  1. Nistri, A., and Constanti, A., Progr. Neurobiol.13 (1979) 117.

    Article  CAS  Google Scholar 

  2. Dunlap, K., Br. J. Pharmac.74 (1981) 579

    Article  CAS  Google Scholar 

  3. Desarmenien, M., Feltz, P., Loeffler, J. P., Occhipinti, G., and Santangelo, F., Br. J. Pharmac.76 (1982) 289 P.

  4. Krnjević, K. Puil, E., and Werman, R., Can. J. Physiol. Pharmac.55 (1977) 658.

    Article  Google Scholar 

  5. Brown, D. A., and Marsh, S., Brain Res.156 (1978) 187.

    Article  CAS  PubMed  Google Scholar 

  6. Schwindt, P. C., in: Prog neurobiology, p.750. Eds R. Llinás and W. Precht, Springer, Berlin 1976.

    Chapter  Google Scholar 

  7. Arenson, M. S., and Nistri, A., J. Physiol., Lond.319 (1981) 24P.

    Google Scholar 

  8. Davidoff, R. A., and Adair, R., J. Neurochem.24 (1975) 545.

    Article  CAS  PubMed  Google Scholar 

  9. Allan, R. D., Evans, R. H., and Johnston, G. A. R., Br. J. Pharmac.70 (1980) 609.

    Article  CAS  Google Scholar 

  10. Barrett, E. F., and Barrett, J. N., J. Physiol., Lond.323 (1982) 117.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Puil, E., and Werman, R., Can. J. Physiol. Pharmac.59 (1981) 1280.

    Article  CAS  Google Scholar 

  12. Cahalan, M., in: Physiology and pathobiology of axons, p. 158. Ed. S. G. Waxman Raven Press, New York 1978.

    Google Scholar 

  13. Matthews, G., and Wickelgren, W. O., J. Physiol., Lond.293 (1979) 393.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Dunlap, K., and Fischbach, G. D., Nature276 (1978) 837.

    Article  CAS  PubMed  Google Scholar 

  15. Hagiwara, S., and Byerly, L., A. Rev. Neurosci.4 (1981) 69.

    Article  CAS  Google Scholar 

  16. Willard, A. L., J. Physiol. Lond.301 (1980) 115.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Smart, T. G., Br. J. Pharmac.71 (1981) 279.

    Article  Google Scholar 

  18. Conradi, S., in: The peripheral nerve, p. 295. Ed. D. N. Landon. Chapman and Hall, London 1976.

    Google Scholar 

  19. Shoulson, I., Chase, T. N., Roberts, E., and Van Balgooy, J. N., Engl. J. Med.293 (1975) 504.

    CAS  Google Scholar 

  20. Barbeau, A., Lancet2 (1973) 1499.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, St. Bartholomew's Hospital Medical College, University of London, EC1M 6BQ, London, England

    M. S. Arenson & A. Nistri

Authors
  1. M. S. Arenson
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  2. A. Nistri
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The authors gratefully acknowledge support from The Joint Research Board of St. Bartholomew's Hospital.

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Arenson, M.S., Nistri, A. The inhibitory amino acid GABA hyperpolarizes motor axons: an intracellular study. Experientia 39, 225–228 (1983). https://doi.org/10.1007/BF01958914

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