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Protamine inhibits adenylate cyclase activity: a possible reason for the toxicity of protamine

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  • Pharmacology, Toxicology
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Summary

Protamine is an effective inhibitor of the various activated forms of adenylate cyclase of liver plasma membranes. Inhibition of adenylate cyclase may account for its toxic but not its antitumor effects.

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Author notes

  1. Z. Kiss

    Present address: Biological Sciences Group, U44, The University of Connecticut, 06268, Storrs, Connecticut, USA

Authors and Affiliations

  1. Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, P. O. Box 521, H-6701, Szeged, Hungary

    Z. Kiss & R. Zamfirova

Authors
  1. Z. Kiss
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  2. R. Zamfirova
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Kiss, Z., Zamfirova, R. Protamine inhibits adenylate cyclase activity: a possible reason for the toxicity of protamine. Experientia 39, 1381–1382 (1983). https://doi.org/10.1007/BF01990114

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  • DOI: https://doi.org/10.1007/BF01990114

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