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Submandibular gland-conditioned medium enhancement of bone marrow colony-forming cells in tumor-bearing murine recipients

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Summary

Soft-agar clonogenic assay techniques were used to examine 2 sources of colony-stimulating activity (CSA), submandibular gland-conditioned medium (SMG-CM) and pregnant mouse uterine extract (PMUE), for potentiation of granulocyte-macrophage (GM-CFUc) or monocyte-macrophage (M-CFUc) progenitor cell populations. The femoral populations being examined were aspirated from normal mice and from those bearing 1 of 2 types of tumor: Lewis lung carcinoma (3LL) or thymic lymphoma ascites tumor (EL-4). When PMUE was used as a CSA source, normal animals showed a greater clonogenic response per population than either of the tumor-bearing groups. When SMG-CM was used as a CSA source, the pattern of GM-CFUc response was much different: GM-CFUc magnitudes increased by fourfold to sixfold over normal levels in tumor-bearing animals. M-CFUc response patterns were also significant, being similar in response but smaller.

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Authors and Affiliations

  1. Immunology Division, Experimental Hematology Department, Armed Forces Radiobiology Research Institute, 20814, Bethesda, Maryland, USA

    D. F. Gruber & G. D. Ledney

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  1. D. F. Gruber
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  2. G. D. Ledney
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Additional information

Research was conducted according to the principles enunciated in the ‘Guide for the Care and Use of Laboratory Animals’, prepared by the Institute of Laboratory Animal Resources, National Research Council.

Supported by Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, under Research Work Unit MJ 00041. Views presented in this paper are those of the authors. No endorsement by the Defense Nuclear Agency has been given or should be inferred.

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Gruber, D.F., Ledney, G.D. Submandibular gland-conditioned medium enhancement of bone marrow colony-forming cells in tumor-bearing murine recipients. Experientia 39, 101–103 (1983). https://doi.org/10.1007/BF01960653

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