Summary
When N-methylformamide is administered to rats on the 11th day of pregnancy approximately 50% of the fetuses are resorbed and a reduced weight of the developed animals is found in comparison to the controls on the 21th day (delivery by Caesarian section). The toxic effect is increased by using nicotinamide and methionine. If a combination of these substances is employed practically all fetuses are resorbed. Tryptophan, however, has a considerably protective influence.
N-Methylformamide has no influence on the NAD-synthesis induced by nicotinamide or tryptophan. It does, however, inhibits the activity of the ADPR transferase.
Refences
Thiersch, J.B., J. Reprod. Fert.4 (1962) 219.
Oettel, J., and Frohberg, H., Naunyn Schmiedebergs Arch. Pharmak.274 (1964) 363.
Tuchmann-Duplessis, M., and Mercier-Parot, L., C. r. Acad. Sci. Paris261 (1965) 241.
Roll, R., and Bär, F., Arzneimittel-Forsch.17 (1967) 610.
Kreybig, v. Th., Preussmann, R., and Schmidt, W., Arzneimittel-Forsch.18 (1968) 645.
Lorke, D., Ber. Inst. Arzneimittel Bundesgesundheitsamtes1 (1978) 54.
Kröger, H., Grätz, R., and Grahn, H., in preparation.
Nisselbaum, J.G., and Green, G., Analyt. Biochem.27 (1969) 212.
Blobel, G., and Potter, V.R., Science154 (1966) 1662.
Kidwell, W.R., and Burdette, E., Biochem. biophys. Res. Commun.61 (1974) 766.
Warburg, O., and Christian, W., Biochem. Z.275 (1935) 464.
Chambon, P., Weill, J.D., and Mandel, P., Biochem. biophys. Res. Commun.11 (1963) 39.
Caplan, A.J., and Rosenberg, M.J., Proc. natl Acad. Sci. USA72 (1975) 1852.
Morioka, K., Tanaka, K., Nakuo, T., Ishizawa, M., and Ono, T., Gann70 (1979) 37.
Claycomb, W.C., Biochem. J.154 (1976) 387.
Durkacz, B.W., Omidiji, O., Gray, D.A., and Shall, S., Nature, Lond.282 (1980) 593.
Whish, W.J.D., Davis, M.J., and Shall, S., Biochem. biophys. Res. Commun.45 (1975) 722.
Holzer, H., and Kröger, H., Klin. Wschr.36 (1958) 677.
Holzer, H., and Kröger, H., Biochem. Z.330 (1958) 579.
Kröger, H., Ulrich, B., and Holzer, H., Arzneimittel-Forsch.9 (1959) 598.
Kröger, H., Rotthauwe, H.W., Ulrich, B., and Holzer, H., Biochem. Z.333 (1960) 148.
Kröger, H., Rotthauwe, H.W., Ulrich, B., and Holzer, H., Biochem. Z.333 (1960) 155.
Hilz, H., and Stone, P.R., Rev. Physiol. Biochem. Pharmac.76 (1976) 1.
Purnell, M.R., Stone, P.R., and Whish, W.J.D., Soc. Trans.8 (1980) 2.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kröger, H., Grätz, R. & Grahn, H. Influence of N-methylformamide on the development, the NAD synthesis, and the activity of the ADPR transferase of rat embryos. Experientia 39, 93–94 (1983). https://doi.org/10.1007/BF01960647
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01960647