Summary
Methylxanthines consumed daily by most humans were investigated for induction of sister chromatid exchanges (SCE). Effects observed in this highly sensitive in vivo system decreased in the order theophylline/theobromine>caffeine >paraxathine>monomethylxanthines.
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Renner, H.W. Sister chromatid exchanges induced by methylxanthines contained in coffee, tea and cocoa. Experientia 38, 600 (1982). https://doi.org/10.1007/BF02327071
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DOI: https://doi.org/10.1007/BF02327071