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Monoamine oxidase activities in human brain microvessels

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Summary

Microvessels can be easily isolated from human brain samples obtained at autopsy. Human frontal cortex MAO type A and B activities are similar in microvessel and microvessel-free preparations. In microvessels, enzyme activities and the ratio of MAO type A to type B vary among the areas studied and could selectively regulate the passage of certain amines through the blood vessel wall.

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Authors and Affiliations

  1. Department of Pharmacology, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    D. H. Haenick, R. K. Ladman, Janet Weiss, D. H. Boehme & W. H. Vogel

  2. Veterans Administration Hospital, 07019, East Orange, NJ, USA

    D. H. Haenick, R. K. Ladman, Janet Weiss, D. H. Boehme & W. H. Vogel

  3. Thomas Jefferson University, Philadelphia

    W. H. Vogel

Authors
  1. D. H. Haenick
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  2. R. K. Ladman
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  3. Janet Weiss
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  4. D. H. Boehme
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  5. W. H. Vogel
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Additional information

Acknowledgment. The technical assistance of N. Gentile and the financial support by NIMH grant MH31156 is gratefully acknowledged.

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Haenick, D.H., Ladman, R.K., Weiss, J. et al. Monoamine oxidase activities in human brain microvessels. Experientia 37, 764–765 (1981). https://doi.org/10.1007/BF01967968

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