Summary
After active immunization of male rabbits against androstenedione and with increasing antibody titre the concentration of androstenedione and testosterone in peripheral blood increased more than 1000-fold resp. 20-fold above values of control animals. On histological examination of the testes a marked Leydig's cell hyperplasia was found, though there was no difference in testis weight.
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Nechansky, S., Stöckl, W., Skolek, R. et al. Effect of immunization of male rabbits against androstenedione. Experientia 36, 1131–1132 (1980). https://doi.org/10.1007/BF01966012
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DOI: https://doi.org/10.1007/BF01966012