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Synaptic development in brains of rats exposed perinatally to ethanol

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Summary

Development of brain synaptosomal uptakes of3H-norepinephrine and3H-dopamine in pups whose mothers received ethanol were nearly normal. However, development of synaptosomal uptake of3H-serotonin was significantly lower than in controls, while uptake of3H-norepinephrine into synaptic storage vesicles was increased.

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Authors and Affiliations

  1. Department of Pharmacology, Duke University Medical Center, 27710, Durham, N.C., USA

    T. A. Slotkin, S. M. Schanberg & C. M. Kuhn

Authors
  1. T. A. Slotkin
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  2. S. M. Schanberg
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  3. C. M. Kuhn
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Additional information

The authors thank F.J. Seidler and W.L. Whitmore for their technical assistance. Research was supported by U.S. Public Health Service grants AA-02935 and DA-00465. TAS is recipient of Research Scientist Development Award DA-00006 from the National Institute on Drug Abuse, and SMS is recipient of Research Scientist Award MH-06489 from the National Institute of Mental Health.

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Slotkin, T.A., Schanberg, S.M. & Kuhn, C.M. Synaptic development in brains of rats exposed perinatally to ethanol. Experientia 36, 1005–1007 (1980). https://doi.org/10.1007/BF01953850

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  • DOI: https://doi.org/10.1007/BF01953850

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