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Biological activity of the C-terminal octapeptide of cholecystokinin, of three of its analogues and of caerulein in the dog

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Summary

Dose-response curves of the C-terminal octapeptide (CCK-8) of cholecystokinin, of 3 of its methoxinine analogues, and of caerulein for various variables of exocrine pancreatic secretion have been established in conscious dogs. The following relative potencies were calculated for the protein secretion activity of CCK-8 (100%), [Mox3]-CCK-8 (52%), [Mox6]-CCK-8 (27%), [Mox3,Mox6]-CCK-8 (19%) and caerulein (178%).

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Authors and Affiliations

  1. Division of Gastroenterology, Kantonsspital, CH-4031, Basle, Switzerland

    F. D. Meyer, K. Gyr, L. Kayasseh, L. Jeker, M. Wall, A. Trzeciak & D. Gillessen

  2. Electronic Data Processing and Diagnostic Research Department, F. Hoffmann-La Roche & Co., Ltd., CH-4002, Basle, Switzerland

    F. D. Meyer, K. Gyr, L. Kayasseh, L. Jeker, M. Wall, A. Trzeciak & D. Gillessen

Authors
  1. F. D. Meyer
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  2. K. Gyr
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  3. L. Kayasseh
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  4. L. Jeker
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  5. M. Wall
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  6. A. Trzeciak
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  7. D. Gillessen
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Additional information

Acknowledgments. The authors are grateful to Dr C. Beglinger for technical cooperation, Prof. G.A. Stalder for his advice and Mrs C. Frei for typing the manuscript. This study was supplied by grant No. 3.816-076 of the Swiss National Foundation for Scientific Research.

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Meyer, F.D., Gyr, K., Kayasseh, L. et al. Biological activity of the C-terminal octapeptide of cholecystokinin, of three of its analogues and of caerulein in the dog. Experientia 36, 434–436 (1980). https://doi.org/10.1007/BF01975132

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  • DOI: https://doi.org/10.1007/BF01975132

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