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Effect of testosterone on the hypothalamic-pituitary-gonadal axis of pinealectomized and pineal-intact male rats

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Summary

Previous studies indicate that steroid hormones alter pineal biochemistry, and it has been suggested that at least part of the negative feedback effect of steroid hormones on pituitary gonadotropin release may be mediated by the pineal gland. In this study, pinealectomy did not alter the inhibitory effect of testosterone on neuroendocrine-gonadal activity in the male rat, suggesting that the pineal gland does not mediate the response of the rat hypothalamic-pituitary axis to testosterone.

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Authors and Affiliations

  1. Department of Life Sciences, University of Wisconsin-Parkside, 53141, Kenosha, Wisconsin, USA

    E. P. Wallen & F. W. Turek

  2. Department of Biological Sciences, Northwestern University, 60201, Evanston, Illinois, USA

    E. P. Wallen & F. W. Turek

Authors
  1. E. P. Wallen
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  2. F. W. Turek
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Additional information

We wish to thank Susan H. Losee, Brigitte G. Mann and John Georgeson for excellent technical assistance. This investigation was supported by NSF grant SER 77-03836 and a grant from the University of Wisconsin-Parkside Committee on Research to E.P.W. and by NIH grant HD-09885 and NSF grant PCM 76-09955 to F.W.T.

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Wallen, E.P., Turek, F.W. Effect of testosterone on the hypothalamic-pituitary-gonadal axis of pinealectomized and pineal-intact male rats. Experientia 35, 705–706 (1979). https://doi.org/10.1007/BF01960410

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