Summary
4-Isothiocyanato-4′-nitrodiphenylamine possessed anthelmintic activity againstNippostrongylus dubius andHymenolepis nana in mice andH. diminuta in rats as determined by both egg counts and recovery of parasites at autopsy. No activity was detected against the cestode,Spirometra mansonoides, in cats.
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References
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This investigation was supported in part by grants AI-10512 and AI-09483 from the National Institutes of Health. The authors are indebted to Dr P.P. Weinstein for providing animals infected withSpirometra mansonoides.
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Middleton, K.R., Schaefer, F.W. & Saz, H.J. Chemotherapeutic effects of 4-isothiocyanato-4′-nitrodiphenylamine (C9333-Go/CGP 4540) on infections withNematospiroides dubius, Hymenolepis diminuta, Hymenolepis nana andSpirometra mansonoides. Experientia 35, 243–244 (1979). https://doi.org/10.1007/BF01920641
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DOI: https://doi.org/10.1007/BF01920641