Summary
A mutagenic effect of saccharin in Chinese hamsters, using the in vivo SCE test, was observed when massive overdoses were administered; cyclamate was not mutagenic.
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References
Food Chemical News, Nov. 20 (1978).
D.L. Arnold, C.A. Moodie, M.C. Grice, S.M. Charbonnean and I.C. Munro, Toxicology Research Division, Health Protection Branch, Ottawa, Canada, April 1977.
P.G.N. Kramers, Mut. Res.32, 81 (1975).
S. Wolff, B. Rodin, Science200, 543 (1978).
D.T. Arakaki and W. Schmid, Humangenetik11, 119 (1971).
W. Vogel and Th. Bauknecht, Nature260, 448 (1976).
J.W. Allen and S.A. Latt, Nature260, 449 (1976).
J.W. Allen, C.F. Shuler, R.W. Mendes and S.A. Latt, Cytogenet. Cell Genet.18, 231 (1977).
.W. Renner, Drug Res., in press (1979).
FAO Nutrition Meetings Report Series No. 44A, WHO/Food Add./68.33, 1967.
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Renner, H.W. Possible mutagenic activity of saccharin. Experientia 35, 1364–1365 (1979). https://doi.org/10.1007/BF01964011
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DOI: https://doi.org/10.1007/BF01964011