Summary
The carotenoid crocetin was found to be taken up by normal rat muscle cells grown in vitro, and was found in the ribosomal-microsomal fraction, supporting the hypothesis that crocetin affects cell division enzymatic processes.
Similar content being viewed by others
References
G.M. Chisolm, J.L. Gainer, G.E. Stoner and J.V. Gainer, Atherosclerosis15, 327 (1972).
G.M. Chisolm, J.L. Gainer, G.E. Stoner and J.V. Gainer, in: Oxygen Transport to Tissue, p. 729. Ed. D.F. Bruley and H.I. Bicher. Plenum Press, New York 1973.
J.L. Gainer and G.M. Chisolm, Atherosclerosis19, 135 (1974).
G.M. Chisolm and J.L. Gainer, Experientia29, 167 (1973).
N.M. Sulkin and D.F. Sulkin, Lab. Invest.14, 1523 (1965).
E.S. Wilkins, Thesis, University of Virginia, Charlottesville 1973.
Crocetin Application for Therapeutic Use, University of Virginia Patent Program, 1976.
E.S. Wilkins, Thesis, University of Virginia, Charlottesville 1976.
E.S. Wilkins, J.L. Gainer and M.G. Wilkins, Cancer Biochem. Biophys., accepted for publication.
John Paul, Cell & Tissue Culture, 5th ed., Livingstone, Edinburg, London, New York 1975.
W.W. Umbereit, R.H. Burris and J.F. Stanffer, in: Manometric & Biochemical Techniques, p. 238. Burgess Publishing Co., Minneapolis, Minnesota, 1972.
W. Bloom and D.W. Fawcett, in: Text Book of Histology, 10th ed., p. 12. W.B. Saunders Co., Philadelphia 1975.
A.L. Lehninger, in: Biochemistry. Worth Publisher, Inc., New York 1970.
P. Karrer and H. Salomon, Helv. chim. Acta10, 397 (1927).
P. Karrer and H. Salomon, Helv. chim. Acta11, 513 (1928).
P. Karrer and Kozo Miki, Helv. chim. Acta12, 985 (1929).
P. Karrer and A. Helfenstein, Helv. chim. Acta13, 392 (1930).
K.G. Denbigh and J.C.R. Turner, in: Chemical Reactor Theory. Cambridge University Press, 1971.
R.E. Blaxhiser and M.R. Samuel, in: Chemical Engineering Thermodynamics. Prentice-Hall Inc., Englewood Cliffs, N.J. 1972.
A.C. Guyton, in: Handbook of Medical Physiology, 4th ed. W.B. Saunders Co., Philadelphia/Toronto 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wilkins, E.S., Wilkins, M.G. Studies of the mechanism of action of the carotenoid crocetin. Experientia 35, 84–86 (1979). https://doi.org/10.1007/BF01917893
Issue Date:
DOI: https://doi.org/10.1007/BF01917893