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Infusion at constant rate in vivo

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Summary

Infusion can be maintained at a constant rate over an extended period of time in vivo by the use of an implanted diffusion chamber. Plasma59Fe was maintained at a constant level for 10 days when infused from a s.c. implant. Injected isotope was cleared exponentially with a half-clearance time of about 8 h.

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Authors and Affiliations

  1. School of Dentistry, Department of Oral Biology, State University of New York/Buffalo, 4510 Main Street, 14226, Buffalo, N.Y., USA

    J. K. Gong & C. DeLuca

Authors
  1. J. K. Gong
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  2. C. DeLuca
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Additional information

This study was supported in part by grants from the U.S. PHS, ROI FD 00800, and the American Cancer Society, P-5134.

Acknowledgments. We thank M. Byers and J.A. Mason for expert technical assistance.

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Gong, J.K., DeLuca, C. Infusion at constant rate in vivo. Experientia 34, 672–673 (1978). https://doi.org/10.1007/BF01937027

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