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The action of conformationally restricted analogues of GABA onLimulus andHelix central neurones

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Summary

Intracellular recordings have been made from GABA sensitive neurones in the central nervous system ofLimulus andHelix. The following conformationally restricted analogues of GABA all possessed GABA-like activity onLimulus neurones andHelix excitatory GABA receptors: muscimol, thiomuscimol, THIP, isoguvacine and piperidine-4-carboxylic acid. It is suggested that GABA interacts with these receptors in a partially extended and almost planar conformation.

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, University of Southampton, S09 3TU, Southampton, England

    Victoria A. James, P. Krogsgaard-Larsen & R. J. Walker

  2. Department of Chemistry BC, Royal School of Pharmacy, DK-2100, Copenhagen, Denmark

    Victoria A. James, P. Krogsgaard-Larsen & R. J. Walker

Authors
  1. Victoria A. James
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  2. P. Krogsgaard-Larsen
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  3. R. J. Walker
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James, V.A., Krogsgaard-Larsen, P. & Walker, R.J. The action of conformationally restricted analogues of GABA onLimulus andHelix central neurones. Experientia 34, 1630–1631 (1978). https://doi.org/10.1007/BF02034718

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  • DOI: https://doi.org/10.1007/BF02034718

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