Summary
Zinc sulphate pretreatment i.p. produces dose-related reductions in stress ulcer incidence in pylorus-occluded rats. The associated increases in gastric wall mucus, in stressed and nonstressed animals, suggest that a similar effect may contribute to its ulcer-reducing ability in man.
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References
I. Häkkinen, K. Hartiala and H. Lang, Acta physiol. scand.66, 333 (1966).
J. De Graef, in: Peptic, Ulcer, p. 155. Ed. C. J. Pfeiffer. Munksgaard, Copenhagen 1971.
C. H. Cho, C. W. Ogle and S. Dai, Eur. J. Pharmac.38, 337 (1976).
S. Dai and C. W. Ogle, Pflügers Arch.336, 111 (1972).
S. Dai and C. W. Ogle, Eur. J. Pharmac.26, 15 (1974).
A. C. B. Dean, in: Carbenoxolone Sodium, p. 33. Ed. J. H. Baron and F. M. Sullivan. Butterworths, London 1970.
P. M. Fraser, R. Doll, M. J. S. Langman, J. J. Misiewicz and H. H. Shawdon, Gut13, 459 (1972).
D. J. Frommer, Med. J. Aust.2, 793 (1975).
K. B. Orr, Med. J. Aust.1, 244 (1976).
C. H. Cho and C. W. Ogle, Eur. J. Pharmac.43, 315 (1977).
C. H. Cho, C. W. Ogle and S. Dai, IRCS Med. Sci.4, 469 (1976).
H. Boström, J. biol. Chem.196, 477 (1952).
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Cho, C.H., Ogle, C.W. Does increased gastric mucus play a role in the ulcer-protecting effects of zinc sulphate?. Experientia 34, 90–91 (1978). https://doi.org/10.1007/BF01921921
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DOI: https://doi.org/10.1007/BF01921921