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Hormonal imputs and brain tryptophan metabolism: The effect of growth hormone

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Riassunto

Nel topo geneticamente nano, che presenta una selettiva carenza di ormone somatotropo (GH) e nel ratto ipofisectomizzato, i livelli cerebrali di 1-triptofano (TP) e di acido 5-idrossi-indolacetico (5-HIAA) sono considerevolmente più elevati che nei controlli, mentre i livelli cerebrali di serotonina (5-HT) sono praticamente immodificati. La somministrazione di GH riduce i livelli di TP e 5-HIAA e non modifica i livelli di 5-HT sia nel topo nano che nel ratto ipofisectomizzato. Questi risultati dimostrano che la carenza di GH è un fattore importante nel determinare le alterazioni del metabolismo della 5-HT presenti in entrambi i modelli sperimentali.

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Authors and Affiliations

  1. Department of Pharmacology and Institute of Pharmacology and Pharmacognosy, University of Milan, Via Vanvitelli 32, I-20129, Milano, Italy

    Daniela Cocchi, Anna di Giulio, A Groppetti, P Mantegazza, E. E. Müller & P. F. Spano (2nd Chair)

Authors
  1. Daniela Cocchi
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  2. Anna di Giulio
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  3. A Groppetti
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  4. P Mantegazza
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  5. E. E. Müller
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  6. P. F. Spano
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Additional information

This work was supported by Grant No. CT73.00682.04 and No. 70.0788.04.115.2380 of the Consiglio Nazionale delle Ricerche, Italy. We thank Mr.Antonio Tarantino, MissAmbrogina Milani and Mr.Roberto Betti for technical assistance and the NIAMD-NIH Pituitary Hormone Program for the supply of growth hormone and prolactin.

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Cocchi, D., di Giulio, A., Groppetti, A. et al. Hormonal imputs and brain tryptophan metabolism: The effect of growth hormone. Experientia 31, 384–386 (1975). https://doi.org/10.1007/BF01922600

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  • DOI: https://doi.org/10.1007/BF01922600

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