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Teratologische Prüfung der Hydrolysenprodukte des Thalidomids

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Summary

N-(o-Carboxybenzoyl)-dl-glutamic acid imide anddl-glutamic acid imide · HCl did not lead to fetal malformations after i.p. administration to pregnant mice; the injected solutions contained 25% Tween 20. Thus, of the 12 hydrolysis products of thalidomide only those 3 which contain the phthalimide moiety show teratogenic activity, i.e. 2-phthalimido-dl-glutaramic acid, 4-phthalimido-dl-glutaramic acid and 2-phthalimido-dl-glutaric acid.

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Author notes

  1. W. Meise & H. Ockenfels

    Present address: Abteilung für Biochemie der Universität Ulm, Neubau Oberer Eselsberg, D-79, Ulm, Deutschland

  2. F. Köhler

    Present address: Institut für Humangenetik der Universität Bonn, Wilhelmsplatz 7, D-53, Bonn, Deutschland

Authors and Affiliations

  1. Pharmazeutisches Institut der Universität Bonn, Kreuzbergweg 26, D-53, Bonn, Deutschland

    W. Meise, H. Ockenfels & F. Köhler

Authors
  1. W. Meise
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  2. H. Ockenfels
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  3. F. Köhler
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Meise, W., Ockenfels, H. & Köhler, F. Teratologische Prüfung der Hydrolysenprodukte des Thalidomids. Experientia 29, 423–424 (1973). https://doi.org/10.1007/BF01926758

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