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Kompensation der teratogenen Wirkung eines Thalidomid-Metaboliten durchl-Glutaminsäure

  • Specialia
  • Anatomica, Histologica, Embryologica, Carcinologica
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Summary

Skeletal defects were observed in the off-spring of SWS-mice following i.p. administration of phthaloyl-l-glutamic acid, a metabolite of thalidomide. The fetuses of animals which receivedl-glutamic acid in addition to the teratogenic drug, did not show any malformations, whereas concurrent i.p. administration of thed-isomer of glutamic acid failed to reverse teratogenicity induced by phthaloyl-l-glutamic acid.

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References

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Authors and Affiliations

  1. Institut für Humangenetik der Universität Bonn, Wilhelmsplatz 7, D-53, Bonn, Deutschland

    F. Köhler

  2. Abteilung für Biochemie der Universität Ulm, Parkstrasse 11, D-69, Ulm, Deutschland

    H. Ockenfels

Authors
  1. F. Köhler
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  2. H. Ockenfels
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Köhler, F., Ockenfels, H. Kompensation der teratogenen Wirkung eines Thalidomid-Metaboliten durchl-Glutaminsäure. Experientia 27, 421–422 (1971). https://doi.org/10.1007/BF02137287

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  • DOI: https://doi.org/10.1007/BF02137287

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