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Zur peripheren sympathikushemmenden Wirkung des Clonidins

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Summary

The influences of clonidine, tetracaine and procaine on the effects of electrical stimulation of the postganglionic sympathetic cardiac nerves have been compared in the isolated perfused rabbit heart. Much lower concentrations of clonidine than of tetracaine were necessary to antagonize the output of noradrenaline and the rise of frequency and contractility. Procaine even in the highest concentration tested did not inhibit the effects of nerve stimulation. In addition to its known central depression of sympathetic tone, clonidine exerts a specific inhibitory action on postganglionic sympathetic neurons.

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Authors and Affiliations

  1. Pharmakologisches Institut, Klinikum Essen der Ruhr-Universität, D-43, Essen, Deutschland

    K. Starke & H. J. Schümann

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  1. K. Starke
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  2. H. J. Schümann
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Starke, K., Schümann, H.J. Zur peripheren sympathikushemmenden Wirkung des Clonidins. Experientia 27, 70–71 (1971). https://doi.org/10.1007/BF02137748

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  • DOI: https://doi.org/10.1007/BF02137748

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