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Metabolism of C21 steroids by incubated adrenals of ACTH treated rats

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En animales tratados crónicamente con ACTH se aumentan o activan los sistemas de la adrenal que catabolizan la corticosterona y los que hidroxilan en C21, a la vez que disminuye la cantidad de radioactividad incorporada a la 18 OH DOC. Esto indica que el ACTH in vivo tiene sobre la adrenal incubada una acción distinta, a veces opuesta, a la del ACTH exógeno agregado in vitro al principio de la incubación.

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This investigation was supported by U.S.P.H.S. grant No. 1-RO5-TWO0200-01.

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Lantos, C.P., Cannata, M.A. Metabolism of C21 steroids by incubated adrenals of ACTH treated rats. Experientia 23, 534–535 (1967). https://doi.org/10.1007/BF02137952

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