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Cytostatischer Wirkungsmechanismus der Methylhydrazine

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Summary

Cytostatic active methylhydrazine derivatives split off formaldehyde after mild dehydrogenation with potassium hexacyanoferrate (III). It is suggested that the primary formedazomethines andN-hydroxymethylderivatives participate in cytostatic efficacy by their alkylating ability (aminomethylation). Formaldehyde alone and its condensation products with hydrogen peroxide especially bis-hydroxymethylperoxide may exert cytostatic effects too.

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Authors and Affiliations

  1. Physiologisch-chemisches Institut der Universität Tübingen, Deutschland

    G. Weitzel, F. Schneider & Anna-Maria Fretzdorff

Authors
  1. G. Weitzel
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  2. F. Schneider
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  3. Anna-Maria Fretzdorff
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Weitzel, G., Schneider, F. & Fretzdorff, AM. Cytostatischer Wirkungsmechanismus der Methylhydrazine. Experientia 20, 38–39 (1964). https://doi.org/10.1007/BF02146031

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