Summary
‘Therapeutic’ concentrations of digitoxigenin (10−7−3× 10−7 g/ml), producing positive inotropic effects, did not alter resting and action potentials of electrically driven guinea-pig auricles. However, ‘toxic’ concentrations of digitoxigenin (5 × 10−7−10−8 g/ml), producing arrhythmias and contracture of the myocardium, had a marked influence upon resting and action potentials and conduction velocity.
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Reuter, H. Über «therapeutische» und «toxische» Digitoxigeninwirkungen auf elektrophysiologische Messgrössen des Meerschweinchenvorhofs. Experientia 19, 600–601 (1963). https://doi.org/10.1007/BF02151013
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DOI: https://doi.org/10.1007/BF02151013