Über «therapeutische» und «toxische» Digitoxigeninwirkungen auf elektrophysiologische Messgrössen des Meerschweinchenvorhofs

Summary

‘Therapeutic’ concentrations of digitoxigenin (10⁻⁷−3× 10⁻⁷ g/ml), producing positive inotropic effects, did not alter resting and action potentials of electrically driven guinea-pig auricles. However, ‘toxic’ concentrations of digitoxigenin (5 × 10⁻⁷−10⁻⁸ g/ml), producing arrhythmias and contracture of the myocardium, had a marked influence upon resting and action potentials and conduction velocity.