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The metabolic fate of thalidomide

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References

  1. H. Keberle, K. Hoffmann, andK. Bernhard, Exper.18, 105 (1962).

    CAS  Google Scholar 

  2. F. Gross, K. Hoffmann, J. Kebrle, andJ. Tripod, Verh. naturf. Ges. Basel67, 479 (1956).

    CAS  Google Scholar 

  3. E. Bütikofer, P. Cottier, P. Imhof, H. Keberle, W. Riess, andK. Schmid, Arch. exp. Path. Pharmak., in print (1962).

  4. H. Keberle, W. Riess, K. Schmid, andK. Hoffmann, Arch. int. Pharmacodyn., in print (1962).

  5. W. Kunz, H. Keller, andH. Mückter, Arzneimittelforsch.8, 426 (1956).

    Google Scholar 

  6. W. J. Doran, Med. Chem.4, 17 (1959) (John Wiley and Sons, Inc., New York).

    Google Scholar 

  7. P. G. Marshall andD. K. Vallance, J. Pharm. Pharmacol.7, 406 (1955).

    Article  PubMed  CAS  Google Scholar 

  8. F. Gross, J. Tripod, andR. Meier, Schweiz. Med. Wschr.85, 305 (1955).

    PubMed  CAS  Google Scholar 

  9. CIBA, Brit. Patent 729453; U.S. Patent 2749346.

  10. J. Redel, J. P. Martinaud, andJ. Roquet, Bull. Soc. chim. France1959, 1641.

  11. P. T. Izzo andS. R. Safir, J. Amer. chem. Soc.81, 4668 (1959).

    Article  CAS  Google Scholar 

  12. G. S. Skinner, J. B. Bicking, andJ. R. Lovett, J. org. Chem.24, 1587 (1959).

    Article  CAS  Google Scholar 

  13. E. Testa, D.B.P. 1074585.

  14. O. Dalmer, C. Diehl, andH. Pieper, U.S. Pat. 2259925.

  15. C. Barkenbus andP. Panzera, J. org. Chem.20, 237 (1955).

    Article  CAS  Google Scholar 

  16. P. C. Butler, J. Amer. pharm. Assoc., Sci. Ed.44, 367 (1955).

    Article  CAS  Google Scholar 

  17. G. S. Skinner andJ. W. Biking, U.S. Pat. 2786838.

  18. P. R. Rasanen andG. L. Jenkins, J. Amer. pharm. Assoc., Sci. Ed.,38, 599 (1949).

    Article  CAS  Google Scholar 

  19. K. Bernhard, M. Just, A. H. Lutz, andJ. P. Vuilleumier, Helv. chim. Acta40, 436 (1957).

    Article  CAS  Google Scholar 

  20. B. Pellmont, A. Studer, andR. Jürgens, Schweiz. med. Wschr.85, 350 (1955).

    PubMed  CAS  Google Scholar 

  21. W. Schallek, A. Kuehn, andD. K. Seppelin, J. Pharmacol. exp. Therap.118, 139 (1956).

    CAS  Google Scholar 

  22. O. Pribilla, Arch. Toxicol.18, 1 (1959).

    CAS  Google Scholar 

  23. W. J. Close andM. A. Spielman, Med. Chem.5, 38 (1961) (John Wiley and Sons, Inc., New York).

    Google Scholar 

  24. S. L. Goodman, E. A. Swinyard, W. C. Brown, D. O. Schiffman, M. S. Greval andE. L. Bliss, J. Pharmacol. exp. Therap.108, 428 (1953).

    CAS  Google Scholar 

  25. V. Ferrari, Il Farmaco, Ed. Pr.,9, 211 (1954).

    CAS  Google Scholar 

  26. R. Fusco andS. Rossi, Il Farmaco, Ed. Sci.,10, 619 (1955).

    CAS  Google Scholar 

  27. J. Belford andD. D. Bonnycastle, J. Pharmacol. exp. Therap.99, 325 (1950).

    CAS  Google Scholar 

  28. P. G. Marshall andD. K. Vallance, J. Pharm. Pharmacol.6, 740 (1954).

    Article  PubMed  CAS  Google Scholar 

  29. F. J. Marshall, J. org. Chem.23, 503 (1958).

    Article  CAS  Google Scholar 

  30. G. Spaccarelli andV. von Breitenberg, Rec. Progr. Med.19, 419 (1955).

    Google Scholar 

  31. E. Testa andR. Ettore, Arch. Pharm.290, 532 (1957).

    Article  CAS  Google Scholar 

  32. R. Handley andA. S. R. Steward, Lancet1952, I, 742.

    Article  Google Scholar 

  33. E. Testa, L. Fontanella, G. Franco, andL. Marini, Helv. chim. Acta42, 2370 (1959).

    Article  CAS  Google Scholar 

  34. G. Maffi, Il Farmaco, Ed. Sci.,14, 176 (1959).

    Google Scholar 

  35. G. Maffi, B. Silvestrini, andG. Bianchi, Il Farmaco, Ed. Sci.,14, 269 (1959).

    Google Scholar 

  36. G. Osterloh andF. Lagler, Arzneimittelforsch.10, 985 (1960).

    PubMed  CAS  Google Scholar 

  37. G. F. Somers, Brit. J. Pharmacol.15, 111 (1960).

    PubMed  PubMed Central  CAS  Google Scholar 

  38. M. Fincato, Boll. Soc. Ital. Biol. sper.33, 872 (1957).

    PubMed  CAS  Google Scholar 

  39. W. L. Kuhn andE. F. van Maanen, J. Pharmacol. exp. Therap.134, 60 (1961); Fed. Proc.19, 264 (1960).

    CAS  Google Scholar 

  40. R. Greene andH. E. A. Farran, Brit. Med. J.1958, II, 1355.

    Article  Google Scholar 

  41. J. McC. Murdoch andG. D. Campbell, Brit. Med. J.1958, I, 84.

    Article  Google Scholar 

  42. D. M. Burley, Med. World (London)93, 26 (1960).

    PubMed  CAS  Google Scholar 

  43. G. Neuhaus andK. Ibe, Med. Klin.55, 544 (1960).

    PubMed  CAS  Google Scholar 

  44. L. P. DeSouza, Brit. Med. J.1959, II, 635.

    Article  Google Scholar 

  45. R. D. MacKenzie andW. R. McGrath, Proc. Soc. exp. Biol. Med.109, 511 (1962).

    Article  PubMed  CAS  Google Scholar 

  46. R. Beckmann andH. H. Kampe, Arzneimittelforsch.11, 45 (1961).

    PubMed  CAS  Google Scholar 

  47. A. A. Bartholomew, Brit. Med. J.1961, II, 1570.

    Article  Google Scholar 

  48. L. C. F. Clievens, Brit. Med. J.1961, II, 1025.

    Google Scholar 

  49. A. L. Florence, Brit. Med. J.1960, II, 1954.

    Article  Google Scholar 

  50. P. M. Fullerton andM. Kremer, Brit. Med. J.1961, II, 855.

    Article  Google Scholar 

  51. K. W. G. Heathfield, Brit. Med. J.1961, II, 1084.

    Article  Google Scholar 

  52. P. Howe, Brit. Med. J.1961, II, 1084, 1570.

    Article  Google Scholar 

  53. E. V. Kuenssberg, J. A. Simpson, andJ. B. Stanton, Brit. Med. J.1961, I, 291.

    Article  Google Scholar 

  54. D. A. Lillicrap, Brit. Med. J.1962, I, 477.

    Article  Google Scholar 

  55. H. J. Raffauf, Dtsch. med. Wschr.86, 935 (1961).

    Article  PubMed  CAS  Google Scholar 

  56. W. F. Robertson, Brit. Med. J.1962, I, 792.

    Article  Google Scholar 

  57. W. Scheid, H. H. Wieck, A. Stammler, A. Kaldetzky, andE. Gibbels, Dtsch. med. Wschr.86, 938 (1961).

    Article  PubMed  CAS  Google Scholar 

  58. J. Shafar, Brit. Med. J.1961, I, 829.

    Article  Google Scholar 

  59. W. Lenz, Diskussionsbemerkung auf der Herbsttagung der Rheinisch-Westf. Kinderärztevereinigung in Düsseldorf (18. 11. 1961); Dtsch. med. Wschr.86, 2555 (1961); Lancet1962, I, 45, 271.

    Google Scholar 

  60. H. R. Wiedemann, Med. Wschr.12, 816 (1961); Med. Welt37, 1863 (1961).

    Google Scholar 

  61. D. M. Burley, Lencet1962, I, 100, 271.

    Article  Google Scholar 

  62. R. E. Devitt andS. Kenny, Lancet1962, I, 430.

    Google Scholar 

  63. A. W. Ferguson, Lancet1962, I, 691.

    Article  Google Scholar 

  64. C. Gyllenswärd, Svenska Läkar-tidningen59, 731 (1962).

    Google Scholar 

  65. D. J. Hayman, Brit. Med. J.1961, II, 1716; Lancet1961, I, 46, 1262.

    Article  Google Scholar 

  66. O. Hepp, Med. Klin.1962, 419.

  67. E. E. Jones andD. A. J. Williamson, Lancet1962, I, 222.

    Article  Google Scholar 

  68. H. S. Kohler, A. M. Fisher, andP. M. Dunn, Lancet1962, I, 326.

    Article  Google Scholar 

  69. The Editors of the Lancet,1961, II, 753;1962, I, 307.

  70. W. G. McBride, Lancet1961, II, 1358.

    Article  Google Scholar 

  71. B. C. Morgan, Brit. Med. J.1962, I, 792.

    Article  Google Scholar 

  72. C. E. Petersen, Medizin. Welt1962, 753.

  73. R. A. Pfeiffer andW. Kosenow, Münch. med. Wschr.104, 68 (1962); Lancet1962, I, 45.

    PubMed  CAS  Google Scholar 

  74. G. Rogerson, Lancet1962, I, 691.

    Google Scholar 

  75. C. Scott Russell andM. D. McKichan, Lancet1962, I, 429.

    Article  Google Scholar 

  76. F. Stabler, Lancet1962, I, 591.

    Google Scholar 

  77. G. F. Somers, Lancet1962, I, 912.

    Article  Google Scholar 

  78. A. L. Speirs, Lancet1962, I, 303.

    Article  Google Scholar 

  79. R. W. Smithells,Lancet 1962, I, 591, 1270.

    Article  Google Scholar 

  80. G. I. Watson, B. C. S. Slater, andJ. C. McDonald, Brit. Med. J.1962, I, 793.

    Article  Google Scholar 

  81. H. Weicker andH. Hungerland, Dtsch. med. Wschr.87, 992 (1962).

    Article  PubMed  CAS  Google Scholar 

  82. A. Willman andJ. G. Dumoulin, Brit. Med. J.1962, I, 477.

    Article  Google Scholar 

  83. F. E. King, B. S. Jackson, andD. A. A. Kidd, J. chem. Soc. (London)1951, 243.

  84. E. Sondheimer andR. W. Holley, J. Amer. chem. Soc.79, 3767 (1957);76, 2467 (1954).

    Article  CAS  Google Scholar 

  85. W. Block andJ. Ebigt, Arzneimittelforsch.10, 709 (1960).

    CAS  Google Scholar 

  86. V. Klingmüller,Biochemie, Physiologie und Klinik der Glutaminsäure (Verl. Edition Cantor Kg./Anlendorf in Württ. 1955).

  87. R. L. M. Synge, Biochem. J.48, 429 (1950).

    Article  Google Scholar 

  88. H. Weil-Malherbe, Physiol. Rev.30, 549 (1950).

    Article  PubMed  CAS  Google Scholar 

  89. H. Weil-Malherbe, Biochem. Soc. Symposia8, 16 (1952).

    Google Scholar 

  90. H. Waelsch, Naturwiss.40, 404 (1953).

    Article  CAS  Google Scholar 

  91. H. Weil-Malherbe, Naturwiss.40, 541 (1953);41, 124 (1954).

    Article  Google Scholar 

  92. F. Kemper, Z. ges. exp. Med.135, 454 (1962).

    Article  PubMed  CAS  Google Scholar 

  93. L. Jaenicke, Angew. Chemie73, 449 (1961).

    Article  CAS  Google Scholar 

  94. H. Tewes, Münch. med. Wschr.104, 269 (1962).

    Google Scholar 

  95. M. L. Murphy, C. P. Dagg, andD. A. Karnofsky, Pediatrics19, 701 (1957).

    Article  PubMed  CAS  Google Scholar 

  96. J. M. Leck andE. L. M. Millar, Brit. Med. J.1962, II, 16.

    Article  Google Scholar 

  97. E. Abderhalden andE. Tetzner, Z. physiol. Chem.232, 79 (1935).

    Article  CAS  Google Scholar 

  98. W. H. Fishman andC. Artom, Proc. Soc. exp. Biol. Med.57, 241 (1944).

    Article  CAS  Google Scholar 

  99. J. G. Wilson, J. chron. Dis.10, 111 (1959).

    Article  PubMed  CAS  Google Scholar 

  100. H. Kalter andJ. Warkany, Physiol. Rev.39, 69 (1959).

    Article  PubMed  CAS  Google Scholar 

  101. F. C. Fraser, J. chron. Dis.10, 97 (1959).

    Article  PubMed  CAS  Google Scholar 

  102. R. McIntosh, J. chron. Dis.10, 139 (1959).

    Article  PubMed  CAS  Google Scholar 

  103. H. Jackson, Pharmacol. Rev.11, 135 (1959).

    PubMed  CAS  Google Scholar 

  104. J. Warkany, J. chron. Dis.10, 84 (1959).

    Article  PubMed  CAS  Google Scholar 

  105. A. Giroud, Biol. Med.44, 1 (1955).

    Google Scholar 

  106. P. Gruenwald, Arch. Path.44, 398 (1947).

    PubMed  CAS  Google Scholar 

  107. G. E. W. Wolstenholme andC. M. O'Connor (Editors), Ciba Foundation Symposium on Congenital Malformations (J. and A. Churchill Ltd., London 1960).

    Google Scholar 

  108. Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity (J. and A. Churchill Ltd., London 1958).

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Generic name for the hypnotic known as Contergan® (Chemie Grünenthal AG.).

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Faigle, J.W., Keberle, H., Riess, W. et al. The metabolic fate of thalidomide. Experientia 18, 389–397 (1962). https://doi.org/10.1007/BF02151479

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