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Novobiocin as uncoupling agent

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Résumé

Les auteurs démontrent que la novobiocine provoque un découplement de l'oxydation phosphorylante dans un homogénat de foic de rat déjà à une concentration 1,575·10−4 M. Les rapports entre l'activité antibactérienne et l'action biochimique de l'antibiotique sont discutés.

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Authors and Affiliations

  1. Clinique Médicale Universitaire, Lausanne

    J. Frei, N. Canal & E. Gori

  2. Istituto di Farmacologia dell'Università, Milano

    J. Frei, N. Canal & E. Gori

Authors
  1. J. Frei
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  2. N. Canal
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  3. E. Gori
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Frei, J., Canal, N. & Gori, E. Novobiocin as uncoupling agent. Experientia 14, 377–378 (1958). https://doi.org/10.1007/BF02159165

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