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Umwandlung von radioaktivem Cortexon in Aldosteron durch Nebennieren-Enzyme

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Summary

Cortexone labeled in the 21-position with C14 yielded radioactive Aldosterone through incubation with beef adrenal homogenate. Its activity, due entirely to the 21 carbon atom, showed that about 48% of the Aldosterone had arisen from a direct conversion of cortexone without intermediate degradation. The low yield by weight in this conversion suggests, however, that cortexone is not the only natural precursor for Aldosterone in the adrenal.

The radioactivity of the corticosterone obtained showed that about 84% of it originated from added cortexone. Lack of radioactivity of the hydrocortisone confirmed that it does not essentially result from cortexone.

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References

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  7. Für die Durchführung dieser Messungen danken wir Herrn Dr.Rometsch bestens.

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Authors and Affiliations

  1. Pharmazeutische Abteilung, Forschungslaboratorien der CIBA Aktiengesellschaft, Basel

    F. W. Kahnt, R. Neher & A. Wettstein

Authors
  1. F. W. Kahnt
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  2. R. Neher
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  3. A. Wettstein
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Additional information

134. Mitteilung über Steroide. Auszugsweise vorgetragen am 3. August 1955 anlässlich des 3. Internat. Kongresses für Biochemie in Brüssel. 133. Mitteilung sieheE. Vischer, Ch. Meystre undA. Wettstein, Helv. chim. Acta38, 1502 (1955).

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Kahnt, F.W., Neher, R. & Wettstein, A. Umwandlung von radioaktivem Cortexon in Aldosteron durch Nebennieren-Enzyme. Experientia 11, 446–447 (1955). https://doi.org/10.1007/BF02172553

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