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The induction of cytochrome P-450 in the alkane-utilizing yeast Lodderomyces elongisporus: Alterations in the microsomal membrane fraction

  • Applied Microbiology
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Summary

The adaptation of Lodderomyces elongisporus cells to n-alkane utilization was found to be connected with several alterations in the enzyme pattern of the whole cell and the microsomal fraction in particular. A strong induction was found for the microsomal localized cytochrome P-450 alkane hydroxylase system and other enzymes which are directly involved in the terminal degradation pathway of n-alkanes (long-chain alcohol and aldehyde dehydrogenases, catalase).

The decrease of the pO2 in the medium enhances the concentration of the constituents of the alkane hydroxylase system as well as that of several other haemoproteins (catalase, cytochrome oxidase), while the long-chain alcohol and aldehyde dehydrogenase enzymes are probably unaffected.

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Authors and Affiliations

  1. Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, Robert-Rössle-Straße 10, DDR-1115, Berlin-Buch, GDR

    Stephan Mauersberger, Wolf-Hagen Schunck & Hans-Georg Müller

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  1. Stephan Mauersberger
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  2. Wolf-Hagen Schunck
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  3. Hans-Georg Müller
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Dedicated to Prof. Dr. W. Scheler on the occasion of his 60th birthday

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Mauersberger, S., Schunck, WH. & Müller, HG. The induction of cytochrome P-450 in the alkane-utilizing yeast Lodderomyces elongisporus: Alterations in the microsomal membrane fraction. Appl Microbiol Biotechnol 19, 29–35 (1984). https://doi.org/10.1007/BF00252813

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  • DOI: https://doi.org/10.1007/BF00252813

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