Laboratory incubators are used to maintain and cultivate microbial and cell cultures. In order to ensure suitable growing conditions and to avoid cell injuries and fast rise and settling times, minimum overshoot and undershoot performance indexes should be considered in the controller design for incubators. Therefore, it is important to build proper models to evaluate the performance of the controllers before implementation. In this study, we propose an approach to build a model for a laboratory incubator. In this approach, the incubator is considered a linear time-invariant single-input, single-output system. Four different model structures, namely auto-regressive exogenous, auto-regressive moving average exogenous, output error and Box–Jenkins, are applied for modeling the system. The parameters of the model structures are estimated by using prediction error methods. The performances of the model structures are evaluated in terms of mean squared error, mean absolute error and goodness of fit. Additionally, residue analysis including auto-correlation and cross-correlation plots is provided. Experiments are carried out in two scenarios. In the first scenario, the identification dataset is collected from the unit-step response, while in the second scenario, it is collected from the pseudorandom binary sequence response. The experimental study shows that the Box–Jenkins model achieves an over 90% fit percentage for the first scenario and an over 95% fit percentage for the second scenario. Based on the experimental results, it is concluded that the Box–Jenkins model can be used as a successful model for laboratory incubators. Full article

Addressing issues such as a low operational condition recognition efficiency, strong subjectivity, and significant fluctuations in Outotec X fluorescence analysis data in copper flotation production, a copper concentrate grade classification model is constructed based on image processing technology and the Stacking ensemble learning algorithm. Firstly, a feature extraction model for copper concentration flotation foam images is established, extracting color, texture, and size statistical features to build a feature dataset. Secondly, to avoid redundancy in the feature data, which could reduce model accuracy, a combined correlation feature selection is employed for dimensionality reduction, with the filtered feature subset being used as the model input. Finally, to fully leverage the strengths of each model, a Stacking ensemble learning copper concentrate grade classification model is constructed with support vector machine (SVM), random forest (RF), and adaptive boosting (AdaBoost) as base models and logistic regression (LR) as the meta-model. The experimental results show that this ensemble model achieves good recognition for different grade categories, with a precision, recall, and F1 score of 90.01%, 89.85%, and 89.93%, respectively. The accuracy of this Stacking ensemble model, with a 7% improvement over Outotec X fluorescence analysis, demonstrates a potential to meet the daily production needs of beneficiation plants. Full article

Strategies to achieve p-type behavior in semiconductor oxides are an important current topic of research. Our study showed that sodium-doped zinc oxide thin films are a plausible approach. The insertion of dopant allowed a transition between n-type p-type electrical behavior in specific temperature ranges around 300 K. Annealing procedures under controlled atmospheres, including Ar, N₂, and O₂, increased the hole density up to a magnitude of 10¹⁶ cm⁻³, although this also reduced the window temperature. The micro-photoluminescence spectra showed an enhancement of defect-related emissions as the dopant content increased. Notably, yellow-green emissions (around 2.38 eV–520 nm) were the most prominent in the as-grown samples. After annealing, a strong redshift of the defect band was observed (around 1.85 eV–670 nm). Our findings showed that p-type ZnO:Na films exhibited emissions associated with RGB primary colors. In a chromaticity diagram, as-grown samples appeared near the white range, annealed films were close to the warm white area, and O₂ annealed films trended within the red range. Full article

An oxidative C–C bond cleavage of tert-cycloalkanols with tetramethylammonium hypochlorite (TMAOCl) has been developed. TMAOCl is easy to prepare from tetramethylammonium hydroxide, and the combination of TMAOCl and AcOH effectively promoted the C–C bond cleavage in a two-phase system without additional phase-transfer reagents. Unstrained tert-cycloalkanols were transformed into ω-chloroalkyl aryl ketones in moderate to excellent yields under metal-free and mild reaction conditions. Full article

A floating greenhouse for growing oyster mushrooms can be operated remotely via a mobile phone. This innovative system can enhance mushroom production and quality while saving time. By using the Android OS operating system on a mobile phone (Internet Mobile Device with Android OS, MGT Model: T10), users can adjust the humidity and temperature within the greenhouse. This approach is particularly beneficial for older adults. Create a smart floating greenhouse that can be controlled remotely to cultivate oyster mushrooms. It would help to enhance the quality of the mushrooms, reduce the time required for cultivation, and increase the yield per planting area. We carefully examined the specifications and proceeded to create a greenhouse that could float. In addition, we have developed a unit that could control temperature and humidity, a solar cell unit, and a rack for growing mushrooms. Our greenhouses were operated remotely. To determine the best conditions for growing plants in a floating greenhouse, we conducted a test to measure temperature and humidity. We then compared our findings to those of a traditional greenhouse test and determined the optimal parameters for floating greenhouse growth. These parameters include growth time, temperature, humidity, and weight. A mushroom nursery that can be controlled remotely and floats on water consists of four main components: a structure to regulate temperature and humidity, solar cells, and mushroom racks. Research shows that mushrooms grown under this automated control system grow better than those grown through traditional methods. The harvest period is shorter, and the yield is higher than the typical yield of 1.81–1.22. When considering the construction and use of remote-controlled floating mushroom nurseries, the daily weight of mushrooms accounted for 20.22%. The company’s investment return rates were found to be 3.47 years, or 580.21 h per year, which is higher than the yield of traditional methods. This mobile phone remote control system, created by Arduino, is tailor-made for cutting-edge floating greenhouses that grow grey oyster mushrooms. It can be operated with ease via mobile devices and is especially user-friendly for elderly individuals. This system enables farmers to produce a high volume of quality breeds. Furthermore, those with fish ponds can utilize the system to increase their profits. Full article

Background: Nowadays, multimodal cancer therapy results in very high survival rates of early-stage breast cancer and microsurgical flap-based breast reconstruction has become safe and reliable, with gradually increasing demand because of its durable and aesthetically pleasing results. This study aimed to explore the impact of different flap shaping and inset techniques on patient-reported outcome measures (PROMs) with regard to the aesthetic result in abdominal flap-based breast reconstruction. Methods: A systematic review was performed screening Pubmed, Cochrane Library and Web of Science for original articles reporting flap inset strategies, concomitantly providing PROMs on the aesthetic result. Results: Of 319 studies identified, six met the inclusion criteria. The studies described different flap rotation options according to the patient’s morphology, different inset planes, and avoidance of the monitoring skin paddle, and suggested that a higher flap-to-mastectomy mass ratio was associated with better aesthetic results. In two comparative studies, according to the PROMs (BREAST-Q, Likert scale) and independent observer judgement, both higher patient satisfaction and superior aesthetic results were observed with the newly described techniques. Conclusions: Emphasis on the aesthetic outcome in terms of breast shape and symmetry, providing an individualized approach of flap inset, considering the contralateral breast’s shape and volume, results in higher satisfaction scores. Full article

Immune checkpoint inhibitors (ICIs) drastically improve therapeutic outcomes for lung cancer, but accurately predicting individual patient responses to ICIs remains a challenge. We performed the genome-wide profiling of 5-hydroxymethylcytosine (5hmC) in 85 plasma cell-free DNA (cfDNA) samples from lung cancer patients and developed a 5hmC signature that was significantly associated with progression-free survival (PFS). We built a 5hmC predictive model to quantify the 5hmC level and validated the model in the validation, test, and control sets. Low weighted predictive scores (wp-scores) were significantly associated with a longer PFS compared to high wp-scores in the validation [median 7.6 versus 1.8 months; p = 0.0012; hazard ratio (HR) 0.12; 95% confidence interval (CI), 0.03–0.54] and test (median 14.9 versus 3.3 months; p = 0.00074; HR 0.10; 95% CI, 0.02–0.50) sets. Objective response rates in patients with a low or high wp-score were 75.0% (95% CI, 42.8–94.5%) versus 0.0% (95% CI, 0.0–60.2%) in the validation set (p = 0.019) and 80.0% (95% CI, 44.4–97.5%) versus 0.0% (95% CI, 0.0–36.9%) in the test set (p = 0.0011). The wp-scores were also significantly associated with PFS in patients receiving single-agent ICI treatment (p < 0.05). In addition, the 5hmC predictive signature demonstrated superior predictive capability to tumor programmed death-ligand 1 and specificity to ICI treatment response prediction. Moreover, we identified novel 5hmC-associated genes and signaling pathways integral to ICI treatment response in lung cancer. This study provides proof-of-concept evidence that the cfDNA 5hmC signature is a robust biomarker for predicting ICI treatment response in lung cancer. Full article

Nowadays, metal oxide semiconductor gas sensors have diverse applications ranging from human health to smart agriculture with the development of Internet of Things (IoT) technologies. However, high operating temperatures and an unsatisfactory detection capability (high sensitivity, fast response/recovery speed, etc.) hinder their integration into the IoT. Herein, a ternary heterostructure was prepared by decorating WO₃ nanoplates with Au and SnO₂ nanoparticles through a facial photochemical deposition method. This was employed as a sensing material for 3-hydroxy-2-butanone (3H-2B), a biomarker of Listeria monocytogenes. These Au/SnO₂–WO₃ nanoplate-based sensors exhibited an excellent response (R_a/R_g = 662) to 25 ppm 3H-2B, which was 24 times higher than that of pure WO₃ nanoplates at 140 °C. Moreover, the 3H-2B sensor showed an ultrafast response and recovery speed to 25 ppm 3H-2B as well as high selectivity. These excellent sensing performances could be attributed to the rich Au/SnO₂–WO₃ active interfaces and the excellent transport of carriers in nanoplates. Furthermore, a wireless portable gas sensor equipped with the Au/SnO₂–WO₃ nanoplates was assembled, which was tested using 3H-2B with known concentrations to study the possibilities of real-time gas monitoring in food quality and safety. Full article

Monitoring plasma concentrations of β-lactam antibiotics is crucial, particularly in critically ill patients, where variations in concentrations can lead to treatment failure or adverse events. Standardized antimicrobial regimens may not be effective for all patients, especially in special groups with altered physiological parameters. Pharmacokinetic/pharmacodynamic (PK/PD) studies highlight the time-dependent antibacterial activity of these antibiotics, emphasizing the need for personalized dosing. Therapeutic drug monitoring (TDM) is essential, requiring rapid and accurate analytical methods for precise determination of drugs in biological material (typically plasma or serum). This study presents a novel capillary zone electrophoresis–tandem mass spectrometry (CZE-MS/MS) method designed for the simultaneous quantification of five penicillin antibiotics, two cephalosporins, one carbapenem, and two β-lactamase inhibitors in a single run. The method involves a simple sample pretreatment—precipitation with organic solvent—and has a run time of 20 min. Optimization of CZE separation conditions revealed that 20 mM ammonium hydrogen carbonate (NH₄HCO₃) serves as the optimal background electrolyte (BGE). Positive electrospray ionization (ESI) mode, with isopropyl alcohol (IP)/10 mM ammonium formate water solution (50/50, v/v) as the sheath liquid, was identified as the optimal condition for MS detection. Method validation according to the Food and Drug Administration (FDA) guideline for development of bioanalytical methods demonstrated satisfactory selectivity, linearity, recovery, robustness, and stability. The method’s practicality was evaluated using the Blue Applicability Grade Index (BAGI), yielding a score of 77.5. Moreover, the greenness of the proposed method was evaluated by two commonly used metric tools—Analytical GREEnness (AGREE) and Green Analytical Procedure Index (GAPI). The developed CZE-MS/MS method offers a practical and reliable approach for quantifying a broad spectrum of β-lactam antibiotics in plasma. Its ability to simultaneously quantify multiple analytes in a single run, coupled with a straightforward sample pretreatment, positions it as a valuable and prospective tool for TDM in critically ill patients. Full article

Carotenoids are pigments that have a range of functions in human health. The carotenoid diatoxanthin is suggested to have antioxidant, anti-inflammatory and chemo-preventive properties. Diatoxanthin is only produced by a few groups of microalgae, where it functions in photoprotection. Its large-scale production in microalgae is currently not feasible. In fact, rapid conversion into the inactive pigment diadinoxanthin is triggered when cells are removed from a high-intensity light source, which is the case during large-scale harvesting of microalgae biomass. Zeaxanthin epoxidase (ZEP) 2 and/or ZEP3 have been suggested to be responsible for the back-conversion of high-light-accumulated diatoxanthin to diadinoxanthin in low-light diatoms. Using CRISPR/Cas9 gene editing technology, we knocked out the ZEP2 and ZEP3 genes in the marine diatom Phaeodactylum tricornutum to investigate their role in the diadinoxanthin–diatoxanthin cycle and determine if one of the mutant strains could function as a diatoxanthin production line. Light-shift experiments proved that ZEP3 encodes the enzyme converting diatoxanthin to diadinoxanthin in low light. Loss of ZEP3 caused the high-light-accumulated diatoxanthin to be stable for several hours after the cultures had been returned to low light, suggesting that zep3 mutant strains could be suitable as commercial production lines of diatoxanthin. Full article

Despite significant progress in Arctic geological studies, a number of principal questions concerning the Paleozoic collisional events remain unanswered. Therefore, the Taimyr Peninsula, representing the only outcropped high Arctic region where magmatic complexes, formed by Hercynian collision between the Siberian Craton and the Kara Block, are well exposed, is crucially important. In this paper we report new geochemical and geochronological data for intrusions in the poorly studied northeastern part of the Taimyr Peninsula. The obtained results in combination with published data show that supra-subduction magmatism at the southern active margin of the Kara Block continued from ca. 345 to 285 Ma (Early Carboniferous to Early Permian), and was followed by a post-collisional magmatic pulse that affected the whole Taimyr across terrane boundaries at ca. 280 Ma in the Early Permian. After cessation of the post-collisional magmatism at ca. 265 Ma, the Taimyr experienced extension, and voluminous magmatic series associated with a Siberian mantle plume were formed between 251 and 228 Ma during the Triassic. The studied post-collisional and plume-related intrusions of the Northeastern Taimyr are generally classified as evolved high-K I-type granites with adakitic affinity. The latter is a regional feature because the majority of the analyzed plume-related granitoids are geochemically similar to high potassium continental adakites. It is suggested that the adakitic geochemical characteristics of the plume-related granitoids resulted from melting of hydrated mafic lower crustal protoliths and were controlled by the source lithology. Comparison of the new results with data available for adjacent areas allows for correlation of terranes on a regional scale and sheds light on the evolution of the Arctic continental margins in general. In the Early–Middle Paleozoic, the Kara Block was part of a continental terrane that formed at the northern edge of Baltica as a result of Neoproterozoic Timanian orogeny. In the Early Carboniferous, the southern margin of Kara turned into an active margin, while its inferred continuation in the eastern Uralian margin of Baltica remained a passive margin until the Early Permian. This discrepancy can be explained by dextral displacement of Kara relative to Baltica that took place in the Early Carboniferous and was later accommodated by the formation of the Taimyr collisional belt in the course of the Early Permian collision between Kara and Siberia. After collision, the Taimyr was incorporated into the northern Eurasian margin as an uplifted block that experienced surface erosion and supplied clastic material in surrounding basins. Full article

The main aim of this work was to assess the possibility of using dried walnut leaves (Juglans regia L.) in the production of wheat bread. In the developed recipe, wheat flour was partially replaced with dried and powdered walnut leaves (WLs) in amounts of 0.5%, 1.0%, 1.5%, 2.0% and 2.5%. Serving as a control sample was wheat bread without WLs. The bread was made using a single-phase method using yeast. As part of the research methodology, laboratory baking parameters (dough yield, total oven loss, bread yield), loaf volume and loaf specific volume were determined. Additionally, the colors of the dough, crust and bread crumb were determined in the CIE L*a*b* space. The crumb texture profile was assessed using the TPA test. Additionally, the antioxidant power and the total phenolic content of the dough and bread were tested. The consumer acceptability of the sensory features of the bread was also assessed. The test results were statistically analyzed using a one-way ANOVA. It was found that enriching the bread recipe with WLs had a significant impact on its quality. The control bread had the highest volume, and replacing wheat flour with dried leaves resulted in a significant reduction in volume, which was greater at higher WLs contents. Similarly, as the proportion of WLs in the recipe increased, a significant decrease in the brightness of both the dough and the crumb of the obtained bread was observed. A texture analysis showed that bread with a WLs content of 2.5% was the most different from the control bread and other tested breads. However, it was found that enriching bread with the unconventional addition of walnut leaves had a very good effect on its health benefits. The antioxidant activity and the content of total phenolics in the bread grew with the increase in the share of WLs in the recipe. Full article

Climbing performance is greatly dependent on the endurance of the finger flexors which, in turn, depends on the ability to deliver and use oxygen within the muscle. Near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) have provided new possibilities to explore these phenomena in the microvascular environment. The aim of the present study was to explore climbing-related microvascular adaptations through the comparison of the oxygen concentration and hemodynamics of the forearm between climbers and non-climber active individuals during a vascular occlusion test (VOT). Seventeen climbers and fifteen non-climbers joined the study. Through NIRS and DCS, the oxyhemoglobin (O₂Hb) and deoxyhemoglobin (HHb) concentrations, tissue saturation index (TSI), and blood flow index (BFI) were obtained from the flexor digitorum profundus during the VOT. During the reactive hyperemia, climbers presented greater blood flow slopes (p = 0.043, d = 0.573), as well as greater O₂Hb maximum values (p = 0.001, d = 1.263) and HHb minimum values (p = 0.009, d = 0.998), than non-climbers. The superior hemodynamics presented by climbers could indicate potential training-induced structural and functional adaptations that could enhance oxygen transportation to the muscle, and thus enhance muscle endurance and climbing performance. Full article

The aim of this paper is to study the coupled fixed point of a class of mixed monotone operators in the setting of a subordinate semimetric space. Using the symmetry between the subordinate semimetric space and a JS-space, we generalize the results of Senapati and Dey on JS-spaces. In this paper, we obtain some coupled fixed point results and support them with some examples. Full article

In any city, various social groups coexist and need to have a harmonious symbiosis and optimise how people experience the city. The notion of urban planning incorporates positive city development that is active, socially sustainable, and inclusive. This study aims to identify whether the development of the Mediterranean city of Limassol, Cyprus extends to cover the needs of people with disabilities (PwD), residents, and tourists, emphasising physical impairments regarding the facilities and services provided. Limassol, Cyprus is an interesting case because recent developments aim to establish the city as a friendly living space with varied activities and services. Additionally, the city attracts tourists, and such development can be a competitive advantage as a tourism destination. Semi-structured interviews with PwD have been conducted to analyse their views, aiming to identify the extent to which existing infrastructure and services align with an inclusive model within the framework of sustainability, encompassing the notion of an active city. According to the findings, local government via municipal and tourism authorities should consider inclusivity in all aspects when re-developing urban settings by ensuring accessibility for PwD and offering more services that adhere to the requirements of an active, socially sustainable, and inclusive city. Full article

Greenhouse gas emissions, including CO₂ emissions, are an issue in the energy sector that must be addressed urgently. The energy sector, including electricity, has been given a global aim of net zero emissions (NZE). This article examines three scenarios for reaching net-zero emissions in power supply. These scenarios are baseline, NZE1, and NZE2. The baseline scenario represents power plant capacity planning based on existing regulations in the base year. The net zero emissions consisting of the NZE1 and NZE2 scenarios aim to achieve net zero emissions by 2060. The NZE1 and NZE2 scenarios differ in the usage of nuclear power plant technology. The NZE1 scenario employs advanced costs for small modular reactors and large reactors technology, whilst the NZE2 scenario employs the low cost of small modular reactors and large reactors. The three scenarios were implemented and examined using the low emissions analysis platform software. The analytical results demonstrate that the NZE1 and NZE2 scenarios can meet the net zero emission objective by 2058. The baseline scenario results in power plant capacity planning with an average annual CO₂ emission growth rate of 3.58%. On the other hand, the baseline scenario has the lowest investment expenses, at only 44 billion USD. Full article

The launch azimuth of the Naro Space Center is limited toward the south of the Korean peninsula, at 170 ± 10 degrees, suitable for the polar orbit, sun-synchronous orbit, and safety range issues. In this circumstance, one option to send a satellite into GEO is to perform a dog-leg maneuver during ascent, thus forming a medium-inclination orbit under such a restrictive condition. However, this option requires an immense amount of energy for the dog-leg maneuver, as well as a plane change maneuver. The only remaining option is to raise the apogee to the Moon, utilizing lunar gravity to lower the inclination to near zero and then returning to the vicinity of the Earth at an altitude of 35,786 km without maneuver. In order to design lunar-assisted GEO transfer, all feasible paths are defined, but questions remain about how seasonal variations affect all these potential paths. Therefore, this study aims to design and analyze all available trajectories for the year 2031 using a high-fidelity dynamic model, root-finding algorithm, and well-arranged initial conditions, focusing on the impact of seasonal trends. The simulation results indicate that cislunar free-return trajectories generally require less $\mathit{\Delta }V$ compared to circumlunar free-return trajectories, and circumlunar trajectories are minimally affected by lunisolar effects due to their relatively short return time of flight. Conversely, cislunar trajectories show seasonal variations, so spring and fall seasons require up to 20 m/s less $\mathit{\Delta }V$ than summer and winter seasons due to the relatively long time of return duration. Full article

Itraconazole is an antifungal agent included in the triazole pharmacological classification that belongs to the BCS class II, characterized by a low solubility in an aqueous medium (of 1 ng/mL, at neutral pH), which is frequently translated in a low oral bioavailability but with a high permeability. In this sense, it is necessary to find solutions to increase/improve the solubility of itraconazole in the aqueous environment. The main purpose of this study is the preparation and analysis of five different guest–host inclusion complexes containing intraconazole. Initially, a blind docking process was carried out to determine the interactions between itraconazole and the selected cyclodextrins. The second step of the study was to find out if the active pharmaceutical ingredient was entrapped in the cavity of the cyclodextrin, by using spectroscopic and thermal techniques. Also, the antifungal activity of the inclusion complexes was studied to examine if the entrapment of itraconazole influences the therapeutic effect. The results showed that the active substance was entrapped in the cavity of the cyclodextrins, with a molar ratio of 1:3 (itraconazole–cyclodextrin), and that the therapeutic effect was not influenced by the entrapment. Full article

Tipifarnib is the only targeted therapy breakthrough for HRAS-mutant (HRASmt) recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). The molecular profiles of HRASmt cancers are difficult to explore given the low frequency of HRASmt. This study aims to understand the molecular co-alterations, immune profiles, and clinical outcomes of 524 HRASmt solid tumors including urothelial carcinoma (UC), breast cancer (BC), non-small-cell lung cancer (NSCLC), melanoma, and HNSCC. HRASmt was most common in UC (3.0%), followed by HNSCC (2.82%), melanoma (1.05%), BC (0.45%), and NSCLC (0.44%). HRASmt was absent in Her2+ BC regardless of hormone receptor status. HRASmt was more frequently associated with squamous compared to non-squamous NSCLC (60% vs. 40% in HRASwt, p = 0.002). The tumor microenvironment (TME) of HRASmt demonstrated increased M1 macrophages in triple-negative BC (TNBC), HNSCC, squamous NSCLC, and UC; increased M2 macrophages in TNBC; and increased CD8+ T-cells in HNSCC (all p < 0.05). Finally, HRASmt was associated with shorter overall survival in HNSCC (HR: 1.564, CI: 1.16–2.11, p = 0.003) but not in the other cancer types examined. In conclusion, this study provides new insights into the unique molecular profiles of HRASmt tumors that may help to identify new targets and guide future clinical trial design. Full article

Echinococcosis, especially alveolar echinococcosis (AE), is becoming an emerging/re-emerging disease with a growing number of cases reported globally. The diagnosis of echinococcosis is based mainly on imaging, which may be challenging when the image presentation is atypical. We reported one patient with suspected cystic echinococcosis (CE) by imaging. The cell-free DNA (cfDNA) obtained from sequencing the patient’s plasma before the operation showed that this patient probably had AE with 45 reads mapped to the Echinococcus multilocularis reference genome (Read-Pairs Per Million = 0.24). The patients underwent surgery, and the pathological result showed that the patient had AE. The conventional polymerase chain reaction (PCR) of her lesion sample extraction also indicated that the infection was caused by Echinococcus multilocularis. The follow-up ultrasound after three months indicated no recurrence. We demonstrated that the differentiation of CE and AE by imaging may not be that easy, with further elaboration on the differentiation between AE and CE in different aspects. We demonstrated that it is possible to use patients’ plasma cfDNA mapped to Echinococcus references before the operation to obtain the objective clue of the lesion to facilitate diagnosis. Full article

Background: Access to appropriate healthcare is essential for children’s healthy development. This is lacking in rural and remote areas, impacting health outcomes. Despite efforts to improve access for these communities, to date, no review has systematically mapped the literature on allied health models of care for children with developmental needs. This scoping review seeks to address this knowledge gap. Methods: Adhering to the PRISMA-ScR and Joanna Briggs Institute guidelines, a systematic search was conducted. A total of 8 databases (from inception to May 2023) and 106 grey literature sources were searched. Two reviewers independently undertook a two-stage screening process. Data were extracted using customised tools and narratively synthesised utilising the Institute of Medicine’s quality domains. This review is registered a priori via Open Science Framework. Results: Twenty-five citations were identified within the literature. Varied models of care were reported from five mostly Western countries. Models of care identified in these areas were classified as screening services, role substitution, consultative services, or online-based services. Positive impacts on quality of healthcare were reported across all quality domains (apart from safety) with the domain of effectiveness being the most commonly reported. Conclusions: Multiple models of care are currently in operation for children with developmental needs in rural and remote areas and appear to improve the quality of care. Due to complexities within, and limitations of, the evidence base, it is unclear if one model of care is superior to another. This review provides a basis for further research to explore why some models may be more effective than others. Full article

Phase change thermal energy storage (PCTES) technology has garnered significant attention in addressing thermal management challenges in building HVAC systems. However, the cooling performance of PCTES systems in humid scenarios remains unexplored, which is crucial in subtropical regions, high-humidity underground areas, and densely populated spaces. Taking the mine refuge chamber (MRC) as an example, this study focuses on a passive temperature and humidity control system by employing cold storage phase change plates (PCPs) for 96 h. First, an improved and simplified full-scale numerical model including PCPs and MRC parts is established. Then, the model is validated through the experimental results and solved using a numerical method. Finally, the influence of various factors within the system is investigated and an optimization method involving batch operation is proposed. The results indicate that (1) within 40 h, the use of cold storage PCPs leads to an indoor temperature reduction of 4.8 °C and a 7% decrease in relative humidity; (2) the PCPs show asynchronous states in sensible and latent heat transfer rates; (3) for every 50 additional PCPs, the average indoor temperature increases by 0.6 °C and the relative humidity decreases by 1.5%; (4) implementing batch operation of PCPs ensures that the indoor Heat Index drops by 10 °C, which is vital for human survival. The findings will play a crucial role in the global expansion and application (including geographical and functional aspects) of phase change thermal storage technology. Full article