Cell
Volume 155, Issue 5, 21 November 2013, Pages 983-989
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Perspective
Extracting Insight from Noisy Cellular Networks

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Network biologists attempt to extract meaningful relationships among genes or their products from very noisy data. We argue that what we categorize as noisy data may sometimes reflect noisy biology and therefore may shield a hidden meaning about how networks evolve and how matter is organized in the cell. We present practical solutions, based on existing evolutionary and biophysical concepts, through which our understanding of cell biology can be enormously enriched.

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These authors contributed equally to this work