Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase
The synthesis and nNOS/eNOS activity of 6-(4-(dimethylaminoalkyl)/-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)/-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1–8 are described. These compounds are potent inhibitors of the human nNOS isoform.
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