The 2023 MDPI Annual Report has
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67 pages, 22902 KiB  
Article
A New Non-Extensive Equation of State for the Fluid Phases of Argon, including the Metastable States, from the Melting Line to 2300 K and 50 GPa
by Frédéric Aitken, André Denat and Ferdinand Volino
Fluids 2024, 9(5), 102; https://doi.org/10.3390/fluids9050102 (registering DOI) - 24 Apr 2024
Abstract
A new equation of state for argon was developed with the view of extending the range of validity of the equation of state previously proposed by Tegeler et al. and obtaining a better physical description of the experimental thermodynamic data for the whole [...] Read more.
A new equation of state for argon was developed with the view of extending the range of validity of the equation of state previously proposed by Tegeler et al. and obtaining a better physical description of the experimental thermodynamic data for the whole fluid region (single-phase, metastable, and saturation states). As proposed by Tegeler et al., this equation is also based on a functional form of the residual part of the reduced Helmholtz free energy. However, in this work, the fundamental equation for Helmholtz free energy was derived from the measured quantities CV(ρ, T) and P(ρ, T). The empirical description of the isochoric heat capacity CV(ρ, T) was based on an original empirical description explicitly containing the metastable states. The thermodynamic properties (internal energy, entropy, and free energy) were then obtained by combining the integration of CV(ρ, T). The arbitrary functions introduced by the integration process were deduced from a comparison between calculated and experimental pressure P(ρ, T) data. The new formulation is valid for the whole fluid region from the melting line to 2300 K and for pressures up to 50 GPa. It also predicts the existence of a maximum of the isochoric heat capacity CV along isochors, as experimentally observed in several other fluids. For many applications, an approximate form of the equation of state for the liquid phase may be sufficient. A Tait–Tammann equation is therefore proposed between the triple-point temperature and 148 K. Full article
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19 pages, 1087 KiB  
Article
Milk: A Nutritive and Healthy Food? Consumer Perspective from French and Portuguese Participants
by Marius Bréjon, Francisca Tavares, Sofia G. Florença, João Carlos Gonçalves, Maria João Barroca and Raquel P. F. Guiné
Appl. Sci. 2024, 14(9), 3577; https://doi.org/10.3390/app14093577 (registering DOI) - 24 Apr 2024
Abstract
Milk from different animals is a staple food consumed since immemorial times all over the world. However, there is a lack of knowledge in the scientific literature about knowledge related to milk and its effects on nutrition and health. The objective of this [...] Read more.
Milk from different animals is a staple food consumed since immemorial times all over the world. However, there is a lack of knowledge in the scientific literature about knowledge related to milk and its effects on nutrition and health. The objective of this study was to investigate consumers’ knowledge about milk, its composition, and its effects on human health in two different countries. The study was conducted through a questionnaire survey in Portugal and France and involved 542 participants of whom 332 were French and 210 were Portuguese. For data analysis, we used basic statistics, parametric tests, tree classification, and factor analysis. The results showed that some sociodemographic variables significantly influenced the level of knowledge, namely country (p < 0.001), age (p = 0.029), and the dimension of the household (p < 0.001). Nevertheless, tree classification analyses revealed that other variables such as education, occupation, and body mass index showed some discriminating ability. Factor analysis retained 20 items of the 23 initially tested. The solution contained five factors, two of which had very good internal consistency (alpha values of 0.825 and 0.803). The mean scores for knowledge in practically all factors were consistently higher for the Portuguese as compared with the French sample. In conclusion, the level of knowledge about milk composition and its health effects differs according to several sociodemographic variables, particularly in what constitutes country differences. Full article
(This article belongs to the Section Food Science and Technology)
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19 pages, 13004 KiB  
Article
Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection
by Madison D. McCullough, Marie Muller, Thomas M. Egan and Gregory D. Buckner
Bioengineering 2024, 11(5), 417; https://doi.org/10.3390/bioengineering11050417 (registering DOI) - 24 Apr 2024
Abstract
Pulmonary nodules are abnormal tissue masses in the lungs, typically less than 3.0 cm in diameter, commonly detected during imaging of the chest and lungs. While most pulmonary nodules are not cancerous, surgical resection may be required if growth is detected between scans. [...] Read more.
Pulmonary nodules are abnormal tissue masses in the lungs, typically less than 3.0 cm in diameter, commonly detected during imaging of the chest and lungs. While most pulmonary nodules are not cancerous, surgical resection may be required if growth is detected between scans. This resection is typically performed without the benefit of intraoperative imaging, making it difficult for surgeons to confidently provide appropriate margins. To enhance the efficacy of wedge resection, researchers have developed a modified ultrasound imaging approach that utilizes both multiple scattering (MS) and single scattering (SS) to enhance the accuracy of margin delineation. Clinical deployment of this novel ultrasound technology requires a highly maneuverable ultrasound probe, ideally one that could be deployed and actuated with minimal invasiveness. This study details the design optimization and tradeoff analysis of an actuated continuum probe for pulmonary nodule localization and resection. This device, deployed through intercostal ports, would enable the intraoperative imaging and precise mapping of nodules for improved margin delineation and patient outcomes. To achieve this objective, multiple objective genetic algorithms (MOGAs) and a design of experiments (DOE) study are used to explore the design space and quantify key dimensional relationships and their effects on probe actuation. Full article
(This article belongs to the Special Issue Visual Image Technologies for Respiratory and Circulatory Management)
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16 pages, 976 KiB  
Article
Transformation of the Ukrainian Stock Market: A Data Properties View
by Alex Plastun, Lesia Hariaha, Oleksandr Yatsenko, Olena Hasii and Liudmyla Sliusareva
J. Risk Financial Manag. 2024, 17(5), 177; https://doi.org/10.3390/jrfm17050177 (registering DOI) - 24 Apr 2024
Abstract
This paper investigates the evolution of the Ukrainian stock market through an analysis of various data properties, including persistence, volatility, normality, and resistance to anomalies for the case of daily returns from the PFTS stock index spanning 1995–2022. Segmented into sub-periods, it aims [...] Read more.
This paper investigates the evolution of the Ukrainian stock market through an analysis of various data properties, including persistence, volatility, normality, and resistance to anomalies for the case of daily returns from the PFTS stock index spanning 1995–2022. Segmented into sub-periods, it aims to test the hypothesis that the market’s efficiency has increased over time. To do this different statistical techniques and methods are used, including R/S analysis, ANOVA analysis, regression analysis with dummy variables, t-tests, and others. The findings present a mixed picture: while volatility and persistence demonstrate a general decreasing trend, indicating a potential shift towards a more efficient market, normality tests reveal no discernible differences between analyzed periods. Similarly, the analysis of anomalies shows no specific trends in the market’s resilience to the day-of-the-week effect. Overall, the results suggest a lack of systematic changes in data properties in the Ukrainian stock market over time, possibly due to the country’s volatile conditions, including two revolutions, economic crises, the annexation of territories, and a Russian invasion leading to the largest war in Europe since WWII. The limited impact of reforms and changes justifies the need for continued market reform and evolution post-war. Full article
(This article belongs to the Special Issue Financial Markets, Financial Volatility and Beyond (Volume III))
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13 pages, 2434 KiB  
Article
Experimental Study of Dimensional Effects on Tensile Strength of GFRP Bars
by Hongbo Liu, Thierno Aliou Ka, Nianjiu Su, Yaoyu Zhu, Shuai Guan, Jinxi Long and T. Tafsirojjaman
Buildings 2024, 14(5), 1205; https://doi.org/10.3390/buildings14051205 (registering DOI) - 24 Apr 2024
Abstract
This study explores the mechanical properties of Glass Fiber-Reinforced Polymer (GFRP), a high-performance composite material, focusing on how varying diameters affect its tensile strength, modulus, and elongation. Experimental data obtained from three sets of tensile tests on 10, 12, and 25 mm bars [...] Read more.
This study explores the mechanical properties of Glass Fiber-Reinforced Polymer (GFRP), a high-performance composite material, focusing on how varying diameters affect its tensile strength, modulus, and elongation. Experimental data obtained from three sets of tensile tests on 10, 12, and 25 mm bars helped establish a stress–strain relationship for GFRP reinforcements, considering diameter changes, and a formula for calculating the ultimate tensile strength based on diameter. Utilizing the weakest chain theory and the Weibull distribution, the research found that GFRP’s tensile strength diminished with increased diameter, while the elastic modulus behaves oppositely. The analysis, grounded in the weakest chain theory, identifies the specimen’s effective volume as a critical factor in the size effect of GFRP bars. Moreover, the study proves a significant size effect on GFRP’s tensile properties, validating the theory’s application in predicting the strength of GFRP bars of varying sizes and recommending a specimen length range of 30–40 times its diameter for standardization purposes. Full article
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12 pages, 954 KiB  
Article
Working as a Healthcare Professional at Island Primary Care: An Exploratory Qualitative Study on the Cyclades Islands, Greece
by Anna Maria Kefala, Areti Triantafyllou, Emmanouil K. Symvoulakis, Eleni-Margarita Tzouganatou, Nikolaos Kapellas and Emmanouil Smyrnakis
Healthcare 2024, 12(9), 882; https://doi.org/10.3390/healthcare12090882 (registering DOI) - 24 Apr 2024
Abstract
Improving the quality of and access to healthcare services in rural areas is fundamental to developing sustainable healthcare systems. This research aims to explore the motivations of healthcare professionals to work and settle in rural island areas of Greece with limited access to [...] Read more.
Improving the quality of and access to healthcare services in rural areas is fundamental to developing sustainable healthcare systems. This research aims to explore the motivations of healthcare professionals to work and settle in rural island areas of Greece with limited access to secondary and tertiary care. The study suggests practical ways to encourage self-motivation and attract more health workers in rural areas. An exploratory qualitative research approach was employed, involving semi-structured interviews with 16 healthcare professionals working in primary-care units that lack direct hospital or hospital–health centre access. The research was conducted specifically in the rural islands of the Cyclades. Thematic analysis was conducted to identify common themes and unique insights from the participants. The analysis revealed three thematic categories. Τhe «attraction» thematic was influenced by personal factors, random selection, origin, accommodation factors, professional factors, and obligatoriness. The «recruitment» thematic was associated with understaffing, special care issues, an unstable working environment, educational and organisational aspects, and an insular lifestyle. The thematic of «retention» highlighted personal issues, accommodation difficulties, economic and work-related issues, and unique challenges posed by an insular lifestyle. This research provides valuable insights into the motivations that drive healthcare professionals to settle, work, and remain in remote island units, as well as the challenges they encounter in making this decision. The study proposes strategies to motivate and attract more healthcare professionals to rural areas. These findings should be considered when formulating or reviewing primary healthcare empowerment policies to ensure equitable healthcare access for all individuals. Full article
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17 pages, 881 KiB  
Review
Ketogenic Diet in the Treatment of Epilepsy
by Kinga Borowicz-Reutt, Marlena Krawczyk and Julia Czernia
Nutrients 2024, 16(9), 1258; https://doi.org/10.3390/nu16091258 (registering DOI) - 24 Apr 2024
Abstract
Epilepsy is one of the most disabling neurological diseases. Despite proper pharmacotherapy and the availability of 2nd and 3rd generation antiepileptic drugs, deep brain stimulation, and surgery, up to 30–40% of epilepsy patients remain drug-resistant. Consequences of this phenomenon include not only decreased [...] Read more.
Epilepsy is one of the most disabling neurological diseases. Despite proper pharmacotherapy and the availability of 2nd and 3rd generation antiepileptic drugs, deep brain stimulation, and surgery, up to 30–40% of epilepsy patients remain drug-resistant. Consequences of this phenomenon include not only decreased a quality of life, and cognitive, behavioral, and personal disorders, but also an increased risk of death, i.e., in the mechanism of sudden unexpected death in epilepsy patients (SUDEP). The main goals of epilepsy treatment include three basic issues: achieving the best possible seizure control, avoiding the undesired effects of treatment, and maintaining/improving the quality of patients’ lives. Therefore, numerous attempts are made to offer alternative treatments for drug-resistant seizures, an example of which is the ketogenic diet. It is a long-known but rarely used dietary therapy for intractable seizures. One of the reasons for this is the unpalatability of the classic ketogenic diet, which reduces patient compliance and adherence rates. However, its antiseizure effects are often considered to be worth the effort. Until recently, the diet was considered the last-resort treatment. Currently, it is believed that a ketogenic diet should be used much earlier in patients with well-defined indications. In correctly qualified patients, seizure activity may be reduced by over 90% or even abolished for long periods after the diet is stopped. A ketogenic diet can be used in all age groups, although most of the available literature addresses pediatric epilepsy. In this article, we focus on the mechanisms of action, effectiveness, and adverse effects of different variants of the ketogenic diet, including its classic version, a medium-chain triglyceride diet, a modified Atkins diet, and a low glycemic index treatment. Full article
(This article belongs to the Section Nutrition and Public Health)
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16 pages, 1176 KiB  
Article
A Control-Theoretic Spatio-Temporal Model for Wildfire Smoke Propagation Using UAV-Based Air Pollutant Measurements
by Prabhash Ragbir, Ajith Kaduwela, Xiaodong Lan, Adam Watts and Zhaodan Kong
Drones 2024, 8(5), 169; https://doi.org/10.3390/drones8050169 (registering DOI) - 24 Apr 2024
Abstract
Wildfires have the potential to cause severe damage to vegetation, property and most importantly, human life. In order to minimize these negative impacts, it is crucial that wildfires are detected at the earliest possible stages. A potential solution for early wildfire detection is [...] Read more.
Wildfires have the potential to cause severe damage to vegetation, property and most importantly, human life. In order to minimize these negative impacts, it is crucial that wildfires are detected at the earliest possible stages. A potential solution for early wildfire detection is to utilize unmanned aerial vehicles (UAVs) that are capable of tracking the chemical concentration gradient of smoke emitted by wildfires. A spatiotemporal model of wildfire smoke plume dynamics can allow for efficient tracking of the chemicals by utilizing both real-time information from sensors as well as future information from the model predictions. This study investigates a spatiotemporal modeling approach based on subspace identification (SID) to develop a data-driven smoke plume dynamics model for the purposes of early wildfire detection. The model was learned using CO2 concentration data which were collected using an air quality sensor package onboard a UAV during two prescribed burn experiments. Our model was evaluated by comparing the predicted values to the measured values at random locations and showed mean errors of 6.782 ppm and 30.01 ppm from the two experiments. Additionally, our model was shown to outperform the commonly used Gaussian puff model (GPM) which showed mean errors of 25.799 ppm and 104.492 ppm, respectively. Full article
(This article belongs to the Topic Application of Remote Sensing in Forest Fire)
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13 pages, 8673 KiB  
Protocol
Dedicated Protocol for Ultrastructural Analysis of Farmed Rainbow Trout (Oncorhynchus mykiss) Tissues with Red Mark Syndrome: The Skin—Part One
by Diana Torge, Sara Bernardi, Giulia Ciciarelli, Guido Macchiarelli and Serena Bianchi
Methods Protoc. 2024, 7(3), 37; https://doi.org/10.3390/mps7030037 (registering DOI) - 24 Apr 2024
Abstract
The present study aims to provide a specific protocol for transmission electron microscopy of a sample of skin of rainbow trout affected by red mark syndrome (RMS). The red mark syndrome is a skin disease that affects the rainbow trout (Oncorhynchus mykiss [...] Read more.
The present study aims to provide a specific protocol for transmission electron microscopy of a sample of skin of rainbow trout affected by red mark syndrome (RMS). The red mark syndrome is a skin disease that affects the rainbow trout (Oncorhynchus mykiss). The disease, probably due to the Midichloria-like organism infection, is not lethal, but morbidity can reach up to 60%, leading to significant economic impact associated with the downgrading of the commercial product, increased labor, and susceptibility to secondary infections. The ultrastructure analyses allowed an earlier study to identify the presence of scattered microorganisms characterized by an oval shape, mainly in the cytoplasm of the cells. The protocol developed in this study will be instrumental in visualizing the ultrastructure of the microorganism, which is probably responsible for red mark syndrome infection. Full article
(This article belongs to the Section Tissue Engineering and Organoids)
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12 pages, 355 KiB  
Article
Tunnel Effect for Ultrasonic Waves in Tapered Waveguides
by Massimo Germano
Acoustics 2024, 6(2), 362-373; https://doi.org/10.3390/acoustics6020019 (registering DOI) - 24 Apr 2024
Abstract
Traversal time in the tunneling effect for ultrasonic waves in tapered waveguides is derived considering its analogy with quantum and electromagnetic wave tunneling. If, as traversal time, the so-called phase time is considered, the ultrasonic wave packet shows the equivalent in acoustics of [...] Read more.
Traversal time in the tunneling effect for ultrasonic waves in tapered waveguides is derived considering its analogy with quantum and electromagnetic wave tunneling. If, as traversal time, the so-called phase time is considered, the ultrasonic wave packet shows the equivalent in acoustics of superluminality, i.e., the derived velocity, crosses the limit of bulk transverse ultrasonic waves in the medium of the waveguide that is the equivalent of c in the quantum and electromagnetic cases. The graphs clearly illustrating this so-called Hartman effect are obtained confirming the experimental results in the three different fields. Full article
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25 pages, 8767 KiB  
Article
Dynamic Response Study of Space Large-Span Structure under Stochastic Crowd-Loading Excitation
by Shuwang Yang, Gang Wang, Qiang Xu, Junfu He, Minghao Yang and Chenhao Su
Buildings 2024, 14(5), 1203; https://doi.org/10.3390/buildings14051203 (registering DOI) - 24 Apr 2024
Abstract
With the development of civil engineering, lightweight and high-strength materials, as well as large-span, low-frequency structural systems, are increasingly used. However, its self-oscillation frequency is often close to the stride frequency of pedestrians, which is easily affected by human activities. To study the [...] Read more.
With the development of civil engineering, lightweight and high-strength materials, as well as large-span, low-frequency structural systems, are increasingly used. However, its self-oscillation frequency is often close to the stride frequency of pedestrians, which is easily affected by human activities. To study the effect of human activities on the dynamic response of structures, it is crucial to choose an appropriate anthropogenic load model. Considering the inter-subject and intra-subject variability of pedestrian walking parameters and induced forces in a crowd, we introduce the interaction rules between pedestrians based on the floor field cellular automata (FFCA). A stochastic crowd-loading model coupling walking parameters, induced forces between pedestrians, and induced forces between pedestrians and structures is proposed for simulating crowd-walking loads. The feasibility of the model is verified by comparing the measured response of a space large-span structure with the predicted response of the proposed stochastic crowd-loading model. The comfort level of the structure under different crowd densities was also evaluated based on the model. It was found that both random combinations of walking parameters and dynamic behaviors of pedestrians can cause significant differences in the structural response. Therefore, the crowd-loading model should consider the influence of pedestrian behavioral factors on the structural response. Full article
(This article belongs to the Special Issue Structural Vibration Serviceability and Human Comfort II)
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11 pages, 227 KiB  
Article
The Impact of the Global Pandemic on Veterans with Serious Mental Illness (SMI): Healthcare Utilization and Mortality
by Isabella Soreca, Monique Boudreaux-Kelly, Yeon-Jung Seo and Gretchen Haas
Behav. Sci. 2024, 14(5), 356; https://doi.org/10.3390/bs14050356 (registering DOI) - 24 Apr 2024
Abstract
Background: Individuals with serious mental illness (SMI) experience barriers to accessing and engaging with healthcare, which may have been exacerbated during the emergence of the global pandemic and the rapid shift to telemedicine platforms, substantially decreasing healthcare utilization for non-COVID-19 disorders. Important repercussions [...] Read more.
Background: Individuals with serious mental illness (SMI) experience barriers to accessing and engaging with healthcare, which may have been exacerbated during the emergence of the global pandemic and the rapid shift to telemedicine platforms, substantially decreasing healthcare utilization for non-COVID-19 disorders. Important repercussions on morbidity and mortality may be seen in the months and years to come, which may disproportionately affect high-risk populations, such as patients with SMI, with reduced access to technology platforms. In this study, we explored the impact of the pandemic on healthcare utilization and all-cause mortality rate in SMI compared to non-SMI individuals for the months of March–September 2020 and the same two quarters in 2019. Methods: Data were obtained from the VA Corporate Data Warehouse (CDW), a data repository from clinical and administrative VA systems. The sample included veterans with ≥1 outpatient clinical encounter nationally between 1 January 2019 and 31 December 2020. Results: The cohort for this study included 1,018,047 veterans receiving care through the Veterans Health Administration between 2019 and 2020. Of those, 339,349 had a diagnosis of SMI. Patients with SMI had a significantly larger pre–post-pandemic decrease in outpatient (49.7%, p < 0.001), inpatient (14.4%, p < 0.001), and ED (14.5%, p < 0.001) visits compared to non-SMI patients. Overall, 3752 (1.59%) veterans without SMI and 4562 (1.93%) veterans with SMI died during our observation period. Veterans without SMI who died during the observation period were more likely to have had a positive COVID-19 test compared to veterans with SMI. Unadjusted analyses showed that veterans with SMI were approximately 2.5 times more likely to die than veterans without SMI during the first 6 months of the pandemic, compared to the same two quarters of the previous year. However, after adjustment by pertinent covariates, the predictors associated with an increased risk of death from SMI were older age, being male, a higher CAN score, more inpatient stays in the pre period compared to post, and a positive COVID-19 test. Discussion: Consistent with our initial hypothesis, all the indices of healthcare utilization, namely the number of outpatient, inpatient, and ED visits, significantly decreased between pre- and post-pandemic and did more so for veterans with SMI, despite having more chronic medical illnesses and being prescribed more medications than veterans without SMI. On the other hand, while mortality was greater post-pandemic, factors such as age, morbidity, and having a positive COVID-19 test predicted mortality above and beyond having an SMI diagnosis. Full article
14 pages, 3878 KiB  
Article
Crown Ether Copolymerized Polyimide Film: Enhanced Mechanical, Thermal Properties and Low Dielectric Constant under High Frequency
by Heming Li, Xinming Wang, Ziyang Ding, Weiguo Gao, Yan Liu, Ke Ma, Zhizhi Hu and Yongqi Wang
Polymers 2024, 16(9), 1188; https://doi.org/10.3390/polym16091188 (registering DOI) - 24 Apr 2024
Abstract
Polymer materials with a low dielectric constant and low dielectric loss have the potential to be applied to high-frequency signal transmissions, such as mobile phone antennas and millimeter wave radars. Two types of diamines, 4,4′-diamino-p-tetraphenyl (DPT) and crown ether diamine (CED), were prepared [...] Read more.
Polymer materials with a low dielectric constant and low dielectric loss have the potential to be applied to high-frequency signal transmissions, such as mobile phone antennas and millimeter wave radars. Two types of diamines, 4,4′-diamino-p-tetraphenyl (DPT) and crown ether diamine (CED), were prepared for ternary copolymerization with BPDA in this study. Cross-links with molecular chains were formed, increasing molecular chain distance by utilizing rings of CED. The MPI films exhibit a good thermal performance with the increase in CED addition, with Tg > 380 °C and CTE from −4 × 10−6 K−1 to 5 × 10−6 K−1. The Young’s modulus can reach 8.6 GPa, and the tensile strength is above 200 MPa when 5% and 7% CED are introduced. These MPI films exhibit good mechanical performances. The dielectric constant of PI−10% film can go as low as 3.17. Meanwhile, the relationship between dielectric properties and molecular structure has been demonstrated by Molecular Simulation (MS). PI molecules are separated by low dielectric groups, resulting in a decrease in the dielectric constant. Full article
(This article belongs to the Special Issue Dielectric Properties of Polymers)
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13 pages, 1932 KiB  
Article
BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana
by Wilfred Aniagyei, Sumaya Mohayideen, Osei Sarfo-Kantanka, Sarah Bittner, Monika M. Vivekanandan, Joseph F. Arthur, Agnes O. Boateng, Augustine Yeboah, Hubert S. Ahor, Shadrack O. Asibey, Elizabeth Owusu, Diran Herebian, Maximilian Huttasch, Volker Burkart, Robert Wagner, Michael Roden, Ernest Adankwah, Dorcas O. Owusu, Ertan Mayatepek, Marc Jacobsen, Richard O. Phillips and Julia Seyfarthadd Show full author list remove Hide full author list
Vaccines 2024, 12(5), 452; https://doi.org/10.3390/vaccines12050452 (registering DOI) - 24 Apr 2024
Abstract
BCG vaccination affects other diseases beyond tuberculosis by unknown—potentially immunomodulatory—mechanisms. Recent studies have shown that BCG vaccination administered during overt type 1 diabetes (T1D) improved glycemic control and affected immune and metabolic parameters. Here, we comprehensively characterized Ghanaian T1D patients with or without [...] Read more.
BCG vaccination affects other diseases beyond tuberculosis by unknown—potentially immunomodulatory—mechanisms. Recent studies have shown that BCG vaccination administered during overt type 1 diabetes (T1D) improved glycemic control and affected immune and metabolic parameters. Here, we comprehensively characterized Ghanaian T1D patients with or without routine neonatal BCG vaccination to identify vaccine-associated alterations. Ghanaian long-term T1D patients (n = 108) and matched healthy controls (n = 214) were evaluated for disease-related clinical, metabolic, and immunophenotypic parameters and compared based on their neonatal BCG vaccination status. The majority of study participants were BCG-vaccinated at birth and no differences in vaccination rates were detected between the study groups. Notably, glycemic control metrics, i.e., HbA1c and IDAA1c, showed significantly lower levels in BCG-vaccinated as compared to unvaccinated patients. Immunophenotype comparisons identified higher expression of the T cell activation marker CD25 on CD8+ T cells from BCG-vaccinated T1D patients. Correlation analysis identified a negative correlation between HbA1c levels and CD25 expression on CD8+ T cells. In addition, we observed fractional increases in glycolysis metabolites (phosphoenolpyruvate and 2/3-phosphoglycerate) in BCG-vaccinated T1D patients. These results suggest that neonatal BCG vaccination is associated with better glycemic control and increased activation of CD8+ T cells in T1D patients. Full article
(This article belongs to the Special Issue Immunity and Vaccination against Bacterial Infections)
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12 pages, 690 KiB  
Article
Incidence of a Multicomponent Physical Exercise Program on Body Composition in Overweight or Obese People Aged 60 Years or Older from Chile
by Yazmina Pleticosic-Ramírez, Marcos Mecías-Calvo, Víctor Arufe-Giráldez and Rubén Navarro-Patón
J. Funct. Morphol. Kinesiol. 2024, 9(2), 81; https://doi.org/10.3390/jfmk9020081 (registering DOI) - 24 Apr 2024
Abstract
This research aimed to explore the changes produced in body mass index (BMI), fat mass percentage (FMP), muscle mass percentage (MMP), and visceral fat percentage (VFP) in 60-year-old or over overweight or obese people after a multicomponent exercise program. This quasi-experimental study involved [...] Read more.
This research aimed to explore the changes produced in body mass index (BMI), fat mass percentage (FMP), muscle mass percentage (MMP), and visceral fat percentage (VFP) in 60-year-old or over overweight or obese people after a multicomponent exercise program. This quasi-experimental study involved 70 overweight or obese older people between 60 and 86 years old (M = 73.15; SD = 5.94) who were randomly assigned to a control group (CG, n = 35) and an experimental group (EG, n = 35). At the beginning and at the end of the intervention program, anthropometric and body composition data were collected. The results showed an increase in BMI after the intervention in the CG (p = 0.010) and a decrease in the EG (p < 0.001). The results regarding the FMP indicate a significant decrease in the EG (p < 0.001) after the intervention, as occurs with the VFP (p = 0.003). The MMP increased in the EG (p < 0.001) after the intervention program. Regarding gender, statistically significant differences were found in the MMP after the intervention (p = 0.025), with higher percentages in men in the EG. VFP decreased in both men (p = 0.005) and women (p = 0.019) in the EG. From the results obtained, we can say that a 6-month multicomponent program produces a decrease in BMI, FMP, and VFP and an increase in MMP in its participants. This type of intervention seems to produce a greater increase in muscle mass in men than in women and a decrease in VFP in both genders. Full article
(This article belongs to the Special Issue Research on Sports Nutrition: Body Composition and Performance 3.0)
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15 pages, 4846 KiB  
Article
Effects of Different Thinning Intensities on Carbon Storage in Pinus koraiensis Middle-Aged Plantations in Northeast China
by Nazmus Sakib, Tika Ram Poudel, Yuanqin Hao, Nathan James Roberts, Abdul-Qadir Iddrisu, Saraswoti Adhikari and Peng Zhang
Forests 2024, 15(5), 738; https://doi.org/10.3390/f15050738 (registering DOI) - 24 Apr 2024
Abstract
Forest ecosystems are essential to the global carbon cycle because they are the biggest terrestrial carbon reserves. In the management of forests, thinning is a commonly employed strategy, impacting the respiration and biomass loss of trees, thereby modifying forest carbon dynamics. However, there [...] Read more.
Forest ecosystems are essential to the global carbon cycle because they are the biggest terrestrial carbon reserves. In the management of forests, thinning is a commonly employed strategy, impacting the respiration and biomass loss of trees, thereby modifying forest carbon dynamics. However, there is a lack of scientific research to confirm the impacts of thinning intensities on carbon storage in trees, soil layers, shrubs, and ground vegetation layers as well as its impact on wood production and growth rate. The goal of this study was to find the optimal thinning levels for increasing carbon sequestration during the growth stage of the Korean pine (Pinus koraiensis) middle-aged plantations in Northeast China. In this study, thinning intensity (0, 10, 11, 16, 18, and 22%) affected the carbon storage of trees, tree growth, volume, and, we suspected, soil layer, shrubs, and vegetation (herbs, litter, and grass) also. Specifically, after four years of thinning, the 18% treatment significantly increased total carbon storage, individual organ storage, growth, and tree volume (p < 0.05). These results give us abundant information about how thinning affects the dynamics of carbon storage, wood production, and the interactions between soil and plants in P. koraiensis plantations, contributing to multi-objective management strategies for optimizing carbon sequestration, wood production, and ecosystem health. Full article
(This article belongs to the Special Issue Silviculture and Management Strategy in Coniferous Forests)
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19 pages, 11263 KiB  
Article
Inter-Channel Correlation Modeling and Improved Skewed Histogram Shifting for Reversible Data Hiding in Color Images
by Dan He, Zhanchuan Cai, Dujuan Zhou and Zhihui Chen
Mathematics 2024, 12(9), 1283; https://doi.org/10.3390/math12091283 (registering DOI) - 24 Apr 2024
Abstract
Reversible data hiding (RDH) is an advanced data protection technology that allows the embedding of additional information into an original digital medium while maintaining its integrity. Color images are typical carriers for information because of their rich data content, making them suitable for [...] Read more.
Reversible data hiding (RDH) is an advanced data protection technology that allows the embedding of additional information into an original digital medium while maintaining its integrity. Color images are typical carriers for information because of their rich data content, making them suitable for data embedding. Compared to grayscale images, color images with their three color channels (RGB) enhance data embedding capabilities while increasing algorithmic complexity. When implementing RDH in color images, researchers often exploit the inter-channel correlation to enhance embedding efficiency and minimize the impact on image visual quality. This paper proposes a novel RDH method for color images based on inter-channel correlation modeling and improved skewed histogram shifting. Initially, we construct an inter-channel correlation model based on the relationship among the RGB channels. Subsequently, an extended method for calculating the local complexity of pixels is proposed. Then, we adaptively select the pixel prediction context and design three types of extreme predictors. The improved skewed histogram shifting method is utilized for data embedding and extraction. Finally, experiments conducted on the USC-SIPI and Kodak datasets validate the superiority of our proposed method in terms of image fidelity. Full article
(This article belongs to the Special Issue Advanced Research on Information System Security and Privacy)
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21 pages, 944 KiB  
Review
Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis
by Balázs Lengyel, Rita Magyar-Stang, Hanga Pál, Róbert Debreczeni, Ágnes Dóra Sándor, Andrea Székely, Dániel Gyürki, Benjamin Csippa, Lilla István, Illés Kovács, Péter Sótonyi, Jr. and Zsuzsanna Mihály
J. Clin. Med. 2024, 13(9), 2487; https://doi.org/10.3390/jcm13092487 (registering DOI) - 24 Apr 2024
Abstract
This review aims to explore advancements in perioperative ischemic stroke risk estimation for asymptomatic patients with significant carotid artery stenosis, focusing on Circle of Willis (CoW) morphology based on the CTA or MR diagnostic imaging in the current preoperative diagnostic algorithm. Functional transcranial [...] Read more.
This review aims to explore advancements in perioperative ischemic stroke risk estimation for asymptomatic patients with significant carotid artery stenosis, focusing on Circle of Willis (CoW) morphology based on the CTA or MR diagnostic imaging in the current preoperative diagnostic algorithm. Functional transcranial Doppler (fTCD), near-infrared spectroscopy (NIRS), and optical coherence tomography angiography (OCTA) are discussed in the context of evaluating cerebrovascular reserve capacity and collateral vascular systems, particularly the CoW. These non-invasive diagnostic tools provide additional valuable insights into the cerebral perfusion status. They support biomedical modeling as the gold standard for the prediction of the potential impact of carotid artery stenosis on the hemodynamic changes of cerebral perfusion. Intraoperative risk assessment strategies, including selective shunting, are explored with a focus on CoW variations and their implications for perioperative ischemic stroke and cognitive function decline. By synthesizing these insights, this review underscores the potential of non-invasive diagnostic methods to support clinical decision making and improve asymptomatic patient outcomes by reducing the risk of perioperative ischemic neurological events and preventing further cognitive decline. Full article
(This article belongs to the Special Issue Carotid Artery Disease: Latest Update on Diagnosis and Management)
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22 pages, 1195 KiB  
Review
Host–Microbiome Crosstalk in Chronic Wound Healing
by Mara Mădălina Mihai, Beatrice Bălăceanu-Gurău, Ana Ion, Alina Maria Holban, Cristian-Dorin Gurău, Marius Nicolae Popescu, Cristina Beiu, Liliana Gabriela Popa, Mircea Ioan Popa, Cerasella Cristiana Dragomirescu, Mădălina Preda, Alexandru-Andrei Muntean, Ioana Sabina Macovei and Veronica Lazăr
Int. J. Mol. Sci. 2024, 25(9), 4629; https://doi.org/10.3390/ijms25094629 (registering DOI) - 24 Apr 2024
Abstract
The pathogenesis of chronic wounds (CW) involves a multifaceted interplay of biochemical, immunological, hematological, and microbiological interactions. Biofilm development is a significant virulence trait which enhances microbial survival and pathogenicity and has various implications on the development and management of CW. Biofilms induce [...] Read more.
The pathogenesis of chronic wounds (CW) involves a multifaceted interplay of biochemical, immunological, hematological, and microbiological interactions. Biofilm development is a significant virulence trait which enhances microbial survival and pathogenicity and has various implications on the development and management of CW. Biofilms induce a prolonged suboptimal inflammation in the wound microenvironment, associated with delayed healing. The composition of wound fluid (WF) adds more complexity to the subject, with proven pro-inflammatory properties and an intricate crosstalk among cytokines, chemokines, microRNAs, proteases, growth factors, and ECM components. One approach to achieve information on the mechanisms of disease progression and therapeutic response is the use of multiple high-throughput ‘OMIC’ modalities (genomic, proteomic, lipidomic, metabolomic assays), facilitating the discovery of potential biomarkers for wound healing, which may represent a breakthrough in this field and a major help in addressing delayed wound healing. In this review article, we aim to summarize the current progress achieved in host–microbiome crosstalk in the spectrum of CW healing and highlight future innovative strategies to boost the host immune response against infections, focusing on the interaction between pathogens and their hosts (for instance, by harnessing microorganisms like probiotics), which may serve as the prospective advancement of vaccines and treatments against infections. Full article
(This article belongs to the Special Issue Microbiome and Skin and Mucocutaneous Diseases)
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14 pages, 1508 KiB  
Article
A Mouth and Tongue Interactive Device to Control Wearable Robotic Limbs in Tasks where Human Limbs Are Occupied
by Hongwei Jing, Tianjiao Zheng, Qinghua Zhang, Benshan Liu, Kerui Sun, Lele Li, Jie Zhao and Yanhe Zhu
Biosensors 2024, 14(5), 213; https://doi.org/10.3390/bios14050213 (registering DOI) - 24 Apr 2024
Abstract
The Wearable Robotic Limb (WRL) is a type of robotic arm worn on the human body, aiming to enhance the wearer’s operational capabilities. However, proposing additional methods to control and perceive the WRL when human limbs are heavily occupied with primary tasks presents [...] Read more.
The Wearable Robotic Limb (WRL) is a type of robotic arm worn on the human body, aiming to enhance the wearer’s operational capabilities. However, proposing additional methods to control and perceive the WRL when human limbs are heavily occupied with primary tasks presents a challenge. Existing interactive methods, such as voice, gaze, and electromyography (EMG), have limitations in control precision and convenience. To address this, we have developed an interactive device that utilizes the mouth and tongue. This device is lightweight and compact, allowing wearers to achieve continuous motion and contact force control of the WRL. By using a tongue controller and mouth gas pressure sensor, wearers can control the WRL while also receiving sensitive contact feedback through changes in mouth pressure. To facilitate bidirectional interaction between the wearer and the WRL, we have devised an algorithm that divides WRL control into motion and force-position hybrid modes. In order to evaluate the performance of the device, we conducted an experiment with ten participants tasked with completing a pin-hole assembly task with the assistance of the WRL system. The results show that the device enables continuous control of the position and contact force of the WRL, with users perceiving feedback through mouth airflow resistance. However, the experiment also revealed some shortcomings of the device, including user fatigue and its impact on breathing. After experimental investigation, it was observed that fatigue levels can decrease with training. Experimental studies have revealed that fatigue levels can decrease with training. Furthermore, the limitations of the device have shown potential for improvement through structural enhancements. Overall, our mouth and tongue interactive device shows promising potential in controlling the WRL during tasks where human limbs are occupied. Full article
(This article belongs to the Special Issue Devices and Wearable Devices toward Innovative Applications)
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34 pages, 3395 KiB  
Review
Synergies and Potential of Industry 4.0 and Automated Vehicles in Smart City Infrastructure
by Michal Kaššaj and Tomáš Peráček
Appl. Sci. 2024, 14(9), 3575; https://doi.org/10.3390/app14093575 (registering DOI) - 24 Apr 2024
Abstract
The integration of Industry 4.0 and automated vehicles into the smart cities concept is a topical issue in the urbanization of cities and technological innovation within cities. As it is a relatively modern issue, many aspects of this field have not yet been [...] Read more.
The integration of Industry 4.0 and automated vehicles into the smart cities concept is a topical issue in the urbanization of cities and technological innovation within cities. As it is a relatively modern issue, many aspects of this field have not yet been explored; as a consequence, this paper is concerned with the search for synergies between Industry 4.0 and automated vehicles in smart city infrastructures. There is a lack of contributions in this field that summarize these synergies in a single article and address a wide range of aspects, including transport, energy, communication, and citizen participation. As the field lacks a complete and clear summary of what is already known, which would help multiple stakeholders, the authors decided to conduct this review. The article elucidates the above-stated aspects through a clear and in-depth literature review, which is complemented by specific examples from practice. Of course, the article also includes a description of the synergy potential and the impact on the inhabitants, the environment, and, last but not least, on the overall city life. The main hypothesis of this article is that the integration of Industry 4.0 technologies and automated vehicles within smart city infrastructure will result in significant improvements in transportation efficiency, resource utilization, and overall urban sustainability. The article discusses the positives and negatives of such integration, highlighting, on the one hand, the benefits in terms of reducing environmental impact and improving citizens’ quality of life, but on the other hand, also highlighting the various ethical, legal, and social issues that such integrations may bring. Several methods have been used within the article, namely analysis, synthesis, comparison, and historical interpretation. The final discussion highlights the benefits, as well as the challenges, that such integration faces and must deal with if it is to be successful. It can be concluded that the synergistic potential of automated vehicles and Industry 4.0 in smart city infrastructure is enormous and that such integration offers promising solutions for enhancing transportation efficiency, energy management, and overall urban sustainability. It is also highlighted in the article that, in order to reap the benefits of such synergies, a wide-ranging collaboration of policymakers, industry stakeholders, and urban planners is needed. Full article
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11 pages, 1066 KiB  
Article
Association between Empirical Anti-Pseudomonal Antibiotics and Progression to Thoracic Surgery and Death in Empyema: Database Research
by Akihiro Shiroshita, Kentaro Tochitani, Yohei Maki, Takero Terayama and Yuki Kataoka
Antibiotics 2024, 13(5), 383; https://doi.org/10.3390/antibiotics13050383 (registering DOI) - 24 Apr 2024
Abstract
Evidence on the optimal antibiotic strategy for empyema is lacking. Our database study aimed to evaluate the effectiveness of empirical anti-pseudomonal antibiotics in patients with empyema. We utilised a Japanese real-world data database, focusing on patients aged ≥40 diagnosed with empyema, who underwent [...] Read more.
Evidence on the optimal antibiotic strategy for empyema is lacking. Our database study aimed to evaluate the effectiveness of empirical anti-pseudomonal antibiotics in patients with empyema. We utilised a Japanese real-world data database, focusing on patients aged ≥40 diagnosed with empyema, who underwent thoracostomy and received intravenous antibiotics either upon admission or the following day. Patients administered intravenous vasopressors were excluded. We compared thoracic surgery and death within 90 days after admission between patients treated with empirical anti-pseudomonal and non-anti-pseudomonal antibiotics. Cause-specific hazard ratios for thoracic surgery and death were estimated using Cox proportional hazards models, with adjustment for clinically important confounders. Subgroup analyses entailed the same procedures for patients exhibiting at least one risk factor for multidrug-resistant organisms. Between March 2014 and March 2023, 855 patients with empyema meeting the inclusion criteria were enrolled. Among them, 271 (31.7%) patients received anti-pseudomonal antibiotics. The Cox proportional hazards models indicated that compared to empirical non-anti-pseudomonal antibiotics, empirical anti-pseudomonal antibiotics were associated with higher HRs for thoracic surgery and death within 90 days, respectively. Thus, regardless of the risks of multidrug-resistant organisms, empirical anti-pseudomonal antibiotics did not extend the time to thoracic surgery or death within 90 days. Full article
(This article belongs to the Special Issue Antimicrobial Treatment of Lower Respiratory Tract Infections)
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16 pages, 457 KiB  
Article
Implications of Minimum Description Length for Adversarial Attack in Natural Language Processing
by Kshitiz Tiwari and Lu Zhang
Entropy 2024, 26(5), 354; https://doi.org/10.3390/e26050354 (registering DOI) - 24 Apr 2024
Abstract
Investigating causality to establish novel criteria for training robust natural language processing (NLP) models is an active research area. However, current methods face various challenges such as the difficulties in identifying keyword lexicons and obtaining data from multiple labeled environments. In this paper, [...] Read more.
Investigating causality to establish novel criteria for training robust natural language processing (NLP) models is an active research area. However, current methods face various challenges such as the difficulties in identifying keyword lexicons and obtaining data from multiple labeled environments. In this paper, we study the problem of robust NLP from a complementary but different angle: we treat the behavior of an attack model as a complex causal mechanism and quantify its algorithmic information using the minimum description length (MDL) framework. Specifically, we use masked language modeling (MLM) to measure the “amount of effort” needed to transform from the original text to the altered text. Based on that, we develop techniques for judging whether a specified set of tokens has been altered by the attack, even in the absence of the original text data. Full article
(This article belongs to the Section Information Theory, Probability and Statistics)
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