Synthesis of neurotoxic nephila spider venoms: NSTX-3 and JSTX-3
Graphical abstract
Efficient and practical synthetic routes to the polyamine spider venom principles, NSTX-3 and JSTX-3 are described.
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An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins
2006, TetrahedronCitation Excerpt :Finally, hydrogenation of 28 afforded NSTX-3 (6) in a 36% overall yield from 9 via nine steps. The synthetic compound was fully characterized by the spectroscopic data (IR, 1H and 13C NMR, FABHRMS, ESI-MS/MS), and identified with the natural24 and synthetic toxins.39–41 The Type E polyamine backbone is only slightly different from Type D, that is, the C3 unit is on the right terminal instead of the C4 unit.
Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3
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