Synthesis of neurotoxic nephila spider venoms: NSTX-3 and JSTX-3

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Abstract

Efficient and practical synthetic routes to the polyamine spider venom principles, NSTX-3 and JSTX-3 are described.

Graphical abstract

Efficient and practical synthetic routes to the polyamine spider venom principles, NSTX-3 and JSTX-3 are described.

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  • An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins

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    Citation Excerpt :

    Finally, hydrogenation of 28 afforded NSTX-3 (6) in a 36% overall yield from 9 via nine steps. The synthetic compound was fully characterized by the spectroscopic data (IR, 1H and 13C NMR, FABHRMS, ESI-MS/MS), and identified with the natural24 and synthetic toxins.39–41 The Type E polyamine backbone is only slightly different from Type D, that is, the C3 unit is on the right terminal instead of the C4 unit.

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