The 2023 MDPI Annual Report has
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18 pages, 4618 KiB  
Article
Sustainability in Natural Grassland in the Brazilian Pampa Biome: Livestock Production with CO2 Absorption
by Débora Regina Roberti, Alecsander Mergen, Ricardo Acosta Gotuzzo, Gustavo Pujol Veeck, Tiago Bremm, Luciana Marin, Fernando Luiz Ferreira de Quadros and Rodrigo Josemar Seminoti Jacques
Sustainability 2024, 16(9), 3672; https://doi.org/10.3390/su16093672 (registering DOI) - 27 Apr 2024
Abstract
The Brazilian Pampa biome has natural pastures that have been used for centuries for cattle grazing. This is considered a sustainable system because it combines the conservation of natural vegetation and high-quality meat production, protecting the biome from commercial agriculture’s advances. However, whether [...] Read more.
The Brazilian Pampa biome has natural pastures that have been used for centuries for cattle grazing. This is considered a sustainable system because it combines the conservation of natural vegetation and high-quality meat production, protecting the biome from commercial agriculture’s advances. However, whether it is a source or a sink of carbon dioxide (CO2) has yet to be evaluated. Hence, this study aimed to quantify the net ecosystem exchange (NEE) of the CO2 of a natural pasture of the Pampa biome used for livestock production. The experimental area is located in a subtropical region of southern Brazil, where eddy covariance (EC) measurements were conducted from 2015 to 2021 in a rotational cattle grazing system. The seven months of the warm season (September to March) were characterized as CO2 absorbers, while the five months of the cold season (April to August) were CO2 emitters. Throughout the six years and with complete data, the ecosystem was an absorber of atmospheric CO2, with an average value of −207.6 g C m−2 year−1. However, the significant interannual variability in NEE was observed, with cumulative values ranging from −82.0 to −385.3 g C m−2 year−1. The results suggest the coupling of climatic conditions to pasture management can be the factor that modulated the NEE interannual variability. The cattle raising system on the natural pastures of the Pampa absorbs CO2, which is further evidence of its sustainability and need for conservation. Full article
(This article belongs to the Section Environmental Sustainability and Applications)
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22 pages, 4551 KiB  
Article
Assessment of Leachate Generated by Sargassum spp. in the Mexican Caribe: Part 1 Spatial Variations
by Rosa Maria Leal-Bautista, Juan Carlos Rodriguez-Garcia, Gilberto Acosta-González, Rubi Chablé-Villacis, Raul Tapia-Tussell, Jose Epigmenio Bautista-García, Edgar Olguìn-Maciel, Liliana Alzate-Gaviria and Gloria González-López
Water 2024, 16(9), 1251; https://doi.org/10.3390/w16091251 (registering DOI) - 27 Apr 2024
Abstract
In this study, we evaluate the degradation by Sargassum spp. as a consortium in 2020 and 2021, and by species during 2021, collected at different distances from a coastline and in land deposits. The year 2021 had the largest leachate volume and the [...] Read more.
In this study, we evaluate the degradation by Sargassum spp. as a consortium in 2020 and 2021, and by species during 2021, collected at different distances from a coastline and in land deposits. The year 2021 had the largest leachate volume and the offshore site with the highest volume (60 mL/day) among five sites of collection. In relation to species’ leachate generation, S. fluitans reached 47.67 mL/day as its peak, which is earlier than S. natans (41.67 mL/day 14 days after S. fluitans). pH shows alkaline behavior and EC reflects the saline condition in the leachate, the consortium and species reaching values of pH 7.5 to 8.3 and 80 to 150 mS/cm of EC; the results do not show significant differences among sites, or between species. Despite a BOD/COD ratio of less than 0.1, the degradation process occurs as evidenced by the presence of leachate. The results confirm the existence of a variability in leachate production and the composition of Sargassum under the influence of factors such as the periodicity, site of collection, and proportions of species. Thus, even though these results emphasize leachate generation, knowing the limitations of leachate generation is crucial information for decision making on Sargassum storage and environmental management. Full article
(This article belongs to the Special Issue Marine Ecological Monitoring, Assessment and Protection)
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19 pages, 770 KiB  
Review
Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease—In Vitro and Ex Vivo Animal Studies
by Aleksandra Witkowska, Anna Gryn-Rynko, Patrycja Syrkiewicz, Klaudia Kitala-Tańska and Michał S. Majewski
Nutrients 2024, 16(9), 1313; https://doi.org/10.3390/nu16091313 (registering DOI) - 27 Apr 2024
Abstract
Cardiovascular diseases are a broadly understood concept focusing on vascular and heart dysfunction. Lack of physical exercise, type 2 diabetes, obesity, hypertension, dyslipidemia, thromboembolism, and kidney and lung diseases all contribute to the development of heart and blood vessel dysfunction. Although effective and [...] Read more.
Cardiovascular diseases are a broadly understood concept focusing on vascular and heart dysfunction. Lack of physical exercise, type 2 diabetes, obesity, hypertension, dyslipidemia, thromboembolism, and kidney and lung diseases all contribute to the development of heart and blood vessel dysfunction. Although effective and important, traditional treatment with diuretics, statins, beta blockers, calcium inhibitors, ACE inhibitors, and anti-platelet drugs remains a second-line treatment after dietary interventions and lifestyle changes. Scientists worldwide are still looking for an herbal product that would be effective and free from side effects, either taken together with or before the standard pharmacological intervention. Such herbal-originated medication therapy may include Morus alba L. (white mulberry), Elaeagnus rhamnoides (L.) A. Nelson (sea-buckthorn), Allium sativum L. (garlic), Convallaria majalis L. (lily of the valley), Leonurus cardiaca L. (motherwort), and Crataegus spp. (hawthorn). Valuable herbal raw materials include leaves, fruits, seeds, and even thorns. This short review focuses on six herbs that can constitute an interesting and potential therapeutic option in the management of cardiovascular disorders. Full article
(This article belongs to the Section Phytochemicals and Human Health)
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16 pages, 2510 KiB  
Article
Sonographic Characterization of the Pericruciate Fat Pad with the Use of Compression Elastography—A Cross-Sectional Study among Healthy and Post-Injured Patients
by Michał Kanak, Natalia Pawłuś, Marcin Mostowy, Marcin Piwnik, Marcin Domżalski and Jędrzej Lesman
J. Clin. Med. 2024, 13(9), 2578; https://doi.org/10.3390/jcm13092578 (registering DOI) - 27 Apr 2024
Abstract
Background: The pericruciate fat pad (PCFP) in the knee joint is still insufficiently studied despite its potential role in knee pathologies. This is the first reported study which aimed to clarify the characteristics of the PCFP in healthy individuals and contrast them with [...] Read more.
Background: The pericruciate fat pad (PCFP) in the knee joint is still insufficiently studied despite its potential role in knee pathologies. This is the first reported study which aimed to clarify the characteristics of the PCFP in healthy individuals and contrast them with cases of post-traumatic injuries. Methods: Conducted as a retrospective cross-sectional study (n = 110 knees each) following STROBE guidelines, it employed grayscale ultrasound with echogenicity measurement, compression elastography with elasticity measurement, and Color Doppler for blood flow assessment. Results: PCFP showed a homogenic and hyperechoic echostructure. The echogenicity of the PCFP was higher than that of the posterior cruciate ligament (PCL) (p < 0.001, z-score = 8.97) and of the medial head of gastrocnemius (MHG) (p = 0.007, z-score = 2.72) in healthy knees, but lower than subcutaneous fat (SCF) (p < 0.001, z-score = −6.52). Post-injury/surgery, PCFP echogenicity surpassed other structures (p < 0.001; z-score for PCL 12.2; for MHG 11.65 and for SCF 12.36) and notably exceeded the control group (p < 0.001, z-score = 8.78). PCFP elasticity was lower than MHG and SCF in both groups, with significantly reduced elasticity in post-traumatic knees (ratio SCF/PCFP 15.52 ± 17.87 in case group vs 2.26 ± 2.4 in control group; p < 0.001; z-score = 9.65). Blood flow was detected in 71% of healthy PCFPs with three main patterns. Conclusions: The main findings, indicating increased echogenicity and reduced elasticity of PCFP post-trauma, potentially related to fat pad fibrosis, suggest potential applications of echogenicity and elasticity measurements in detecting and monitoring diverse knee pathologies. The description of vascularity variations supplying the PCFP adds additional value to the study by emphasizing the clinically important role of PCFP as a bridge for the middle genicular artery on its way to the inside of the knee joint. Full article
(This article belongs to the Special Issue Clinical Advances in Musculoskeletal Disorders)
20 pages, 3859 KiB  
Article
Prevalence of Infections and Antimicrobial Resistance of ESKAPE Group Bacteria Isolated from Patients Admitted to the Intensive Care Unit of a County Emergency Hospital in Romania
by Alina-Simona Bereanu, Rareș Bereanu, Cosmin Mohor, Bogdan Ioan Vintilă, Ioana Roxana Codru, Ciprian Olteanu and Mihai Sava
Antibiotics 2024, 13(5), 400; https://doi.org/10.3390/antibiotics13050400 (registering DOI) - 27 Apr 2024
Abstract
The ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella Pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) is a group of bacteria very difficult to treat due to their high ability to acquire resistance to antibiotics and are the [...] Read more.
The ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella Pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) is a group of bacteria very difficult to treat due to their high ability to acquire resistance to antibiotics and are the main cause of nosocomial infections worldwide, posing a threat to global public health. Nosocomial infections with MDR bacteria are found mainly in Intensive Care Units, due to the multitude of maneuvers and invasive medical devices used, the prolonged antibiotic treatments, the serious general condition of these critical patients, and the prolonged duration of hospitalization. Materials and Methods: During a period of one year, from January 2023 to December 2023, this cross-sectional study was conducted on patients diagnosed with sepsis admitted to the Intensive Care Unit of the Sibiu County Emergency Clinical Hospital. Samples taken were tracheal aspirate, catheter tip, pharyngeal exudate, wound secretion, urine culture, blood culture, and peritoneal fluid. Results: The most common bacteria isolated from patients admitted to our Intensive Care Unit was Klebsiella pneumoniae, followed by Acinetobacter baumanii and Pseudomonas aeruginosa. Gram-positive cocci (Enterococcus faecium and Staphilococcus aureus) were rarely isolated. Most of the bacteria isolated were MDR bacteria. Conclusions: The rise of antibiotic and antimicrobial resistance among strains in the nosocomial environment and especially in Intensive Care Units raises serious concerns about limited treatment options. Full article
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18 pages, 4516 KiB  
Article
Cognitive Control Architecture for the Practical Realization of UAV Collision Avoidance
by Qirui Zhang, Ruixuan Wei and Songlin Huang
Sensors 2024, 24(9), 2790; https://doi.org/10.3390/s24092790 (registering DOI) - 27 Apr 2024
Abstract
A highly intelligent system often draws lessons from the unique abilities of humans. Current humanlike models, however, mainly focus on biological behavior, and the brain functions of humans are often overlooked. By drawing inspiration from brain science, this article shows how aspects of [...] Read more.
A highly intelligent system often draws lessons from the unique abilities of humans. Current humanlike models, however, mainly focus on biological behavior, and the brain functions of humans are often overlooked. By drawing inspiration from brain science, this article shows how aspects of brain processing such as sensing, preprocessing, cognition, obstacle learning, behavior, strategy learning, pre-action, and action can be melded together in a coherent manner with cognitive control architecture. This work is based on the notion that the anti-collision response is activated in sequence, which starts from obstacle sensing to action . In the process of collision avoidance, cognition and learning modules continuously control the UAV’s repertoire. Furthermore, simulated and experimental results show that the proposed architecture is effective and feasible. Full article
10 pages, 797 KiB  
Article
Anatomical Possibilities of the Alveolar Bone at the Upper Second Premolar Level
by Alexandru Nicolae Mureşan, Carol Antonio Dandoczi, Răzvan Costin Tudose, Sorin Hostiuc and Mugurel Constantin Rusu
Medicina 2024, 60(5), 726; https://doi.org/10.3390/medicina60050726 (registering DOI) - 27 Apr 2024
Abstract
Background and Objectives: The upper posterior teeth are typically regarded as being exclusively inferior to the maxillary sinus (MS). The expansion of the nasal fossa above the maxillary alveolar base (MAB) needs better investigation. The hypothesis was raised that the MAB in [...] Read more.
Background and Objectives: The upper posterior teeth are typically regarded as being exclusively inferior to the maxillary sinus (MS). The expansion of the nasal fossa above the maxillary alveolar base (MAB) needs better investigation. The hypothesis was raised that the MAB in the upper premolar region, which is usually addressed by surgeons for the elevation of the antral floor, is not exclusively beneath the MS. Therefore, we aimed to document the possible upper relations of the MAB as antral, nasal, or both. Materials and Methods: A total of 145 CBCT scans were used to study four types of MAB: type 1—antral; type 2—antral with a palatal recess; type 3—antral and nasal; type 4—nasal. In type 2, the orthoradial width of the alveolar bone, the rectilinear width of the antral floor, and the maximum depth of the palatal recess were measured. For type 3, the MAB width and the straight widths of the antral and nasal segments of the MAB were measured. Results: Type 1 was found in 67.24%, type 2 in 13.45%, type 3 in 16.21%, and type 4 in 3.1% of the 290 MSs investigated. Palatal recesses were found in 11.72% of the MSs on the right side and 15.17% of the MSs on the left side. Types 1 and 2 exhibited strongly statistically significant bilateral symmetry (Pearson’s Chi2 = 86.42, p < 0.001). Type 3 correlated equally with contralateral types 1 and 3. The bilateral symmetry for types 1–3 was stronger in the males (Pearson’s Chi2 = 47.83, p < 0.001) than in the females (Pearson’s Chi2 = 56.96, p < 0.001). There were no statistically significant associations between sex and the unilateral anatomical type. Conclusions: The MAB in the upper second premolar area should not be considered to be exclusively antral during surgeries or in anatomical teaching. Full article
(This article belongs to the Topic Human Anatomy and Pathophysiology, 2nd Volume)
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12 pages, 1804 KiB  
Article
Precision Agriculture: Assessment of Ergonomic Risks of Assisted Driving System
by Ermanno Vitale, Francesca Vella, Serena Matera, Giuseppe Christian Rizzo, Lucia Rapisarda, Federico Roggio, Giuseppe Musumeci, Venerando Rapisarda, Elio Romano and Veronica Filetti
Appl. Sci. 2024, 14(9), 3738; https://doi.org/10.3390/app14093738 (registering DOI) - 27 Apr 2024
Abstract
Background: the precision agriculture field optimizes resource use, enhancing performance. However, this leads to exposure to ergonomic risks for operators, in particular, tractor drivers, potentially causing musculoskeletal disorders (MSDs). This study investigates how the display position in a semi-automatic tractor system influences operator [...] Read more.
Background: the precision agriculture field optimizes resource use, enhancing performance. However, this leads to exposure to ergonomic risks for operators, in particular, tractor drivers, potentially causing musculoskeletal disorders (MSDs). This study investigates how the display position in a semi-automatic tractor system influences operator comfort and muscle activation during harrowing operations. Methods: the assessment of muscular strain involved the use of surface electromyographic devices, while posture was evaluated throughout the analysis of the distribution of pressure exerted by the operator’s body on the seat, which was observed using two barometric pads, each positioned on the backrest and base of the seat. Finally, infrared thermography (IRT), a non-invasive tool to assess muscle activation, was used to measure the surface temperature of the driver’s back. The results showed a significantly greater muscular activation display for the position of display in semi-automatic driving at 50° and 80°. Conclusions: this study showed how the position of the display on the vehicle negatively influences posture, exposing workers to the risk of developing fatigue and, therefore, discomfort, with the potential onset of MSDs. The combined use of sEMG and IRT allowed for a non-invasive, cheap, and repeatable mechanical and functionality analysis. Full article
(This article belongs to the Section Applied Biosciences and Bioengineering)
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11 pages, 256 KiB  
Entry
COVID-19 and Participatory Music-Making
by Esther M. Morgan-Ellis
Encyclopedia 2024, 4(2), 709-719; https://doi.org/10.3390/encyclopedia4020044 (registering DOI) - 27 Apr 2024
Definition
Participatory music-making is any music-making activity in which individuals engage for the sake of the activity itself. It can be contrasted with presentational music-making, which takes the production of a performance or recording for consumption by an audience as a principal objective. During [...] Read more.
Participatory music-making is any music-making activity in which individuals engage for the sake of the activity itself. It can be contrasted with presentational music-making, which takes the production of a performance or recording for consumption by an audience as a principal objective. During the COVID-19 pandemic, participatory musicians adopted a variety of technological means by which to make music together online. While virtual activities allowed these individuals to sustain their communities and grow as musicians, they did not satisfy all the needs met by in-person music-making. Additionally, online music-making increased access for some but posed barriers to access for others. Virtual participatory music-making remains relevant following the relaxation of pandemic restrictions, and it will likely grow in significance as communications technologies and internet access improve. Full article
(This article belongs to the Collection Encyclopedia of COVID-19)
23 pages, 913 KiB  
Article
Yield, Protein Content and Water-Related Physiologies of Spring Wheat Affected by Fertilizer System and Weather Conditions
by Felicia Chețan, Diana Hirișcău, Teodor Rusu, Marius Bărdaș, Cornel Chețan, Alina Șimon and Paula Ioana Moraru
Agronomy 2024, 14(5), 921; https://doi.org/10.3390/agronomy14050921 (registering DOI) - 27 Apr 2024
Abstract
Technological and climatic factors significantly influence the expression of quality and quantity properties of spring wheat. This study aims to quantify the effects of weather conditions and fertilizer systems on spring wheat yield, quality (protein content), and physiological indicators (leaf vapor pressure deficit, [...] Read more.
Technological and climatic factors significantly influence the expression of quality and quantity properties of spring wheat. This study aims to quantify the effects of weather conditions and fertilizer systems on spring wheat yield, quality (protein content), and physiological indicators (leaf vapor pressure deficit, evapotranspiration, surface temperature of the flag leaf) and to identify a suitable spring wheat genotype for the Transylvanian Plain. The experimental factors were: Y represents the year (Y1, 2019; Y2, 2020); F represents the fertilizer variant (F1, a single rate of fertilization: 36 kg ha−1 of nitrogen; F2, two rates of fertilization: 36 kg ha−1 of nitrogen + 72 kg ha−1 of nitrogen; F3, two rates of fertilization: 36 kg ha−1 of nitrogen + 105 kg ha−1 of nitrogen); and S represents the genotype (S1, Pădureni; S2, Granny; S3, Triso; S4, Taisa; S5, Ciprian; and S6, Lennox). This multifactorial experiment with three factors was conducted on Phaeozem soil. Regardless of weather conditions, fertilization with N100–110 at the head swollen sheath (stage 10, Feeks Growth Scale for Wheat) is deemed the most suitable variant because it yields an average grain yield of 5000 kg ha−1 of good quality (13.84% protein) with a considerable flag leaf area (29 cm2) where physiological processes can optimally support the well-being of the spring wheat plants. Beyond this level of fertilization, the average grain yield tends to plateau, but the protein content considerably increases by 13–23%, depending on the genotype. High yields were achieved in the Lennox and Triso genotypes. Full article
10 pages, 426 KiB  
Article
Biological Control of Escherichia coli O157:H7 in Dairy Manure-Based Compost Using Competitive Exclusion Microorganisms
by Xiuping Jiang and Jingxue Wang
Pathogens 2024, 13(5), 361; https://doi.org/10.3390/pathogens13050361 (registering DOI) - 27 Apr 2024
Abstract
Background: Animal manure-based compost is a valuable organic fertilizer and biological soil amendment. To ensure the microbiological safety of compost products, the effectiveness of competitive exclusion microorganisms (CE) in reducing Escherichia coli O157:H7 in dairy manure-based compost was evaluated. Methods: A cocktail of [...] Read more.
Background: Animal manure-based compost is a valuable organic fertilizer and biological soil amendment. To ensure the microbiological safety of compost products, the effectiveness of competitive exclusion microorganisms (CE) in reducing Escherichia coli O157:H7 in dairy manure-based compost was evaluated. Methods: A cocktail of E. coli O157:H7 strains were inoculated into dairy compost along with CE strains isolated from compost, and the reduction in E. coli O157:H7 by CE was determined in compost with 20%, 30%, and 40% moisture levels at 22 °C and 30 °C under laboratory conditions, as well as in fall, winter, and summer seasons under greenhouse settings. Results: Under lab conditions, CE addition resulted in 1.1–3.36 log reductions in E. coli O157:H7 in compost, with enhanced pathogen reduction by higher moisture and lower temperature. In the greenhouse, >99% of the E. coli O157:H7 population in compost with ≥30% moisture due to cross-contamination can be effectively inactivated by CE within 2 days during colder seasons. However, it took ≥8 days to achieve the same level of reduction for heat-adapted E. coli O157:H7 cells. Conclusions: Our results demonstrated that the competitive exclusion of microorganisms can be an effective tool for controlling foodborne pathogens in compost and reducing the potential for soil and crop contamination. Full article
(This article belongs to the Section Bacterial Pathogens)
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22 pages, 5267 KiB  
Article
Multi-System-Level Analysis with RNA-Seq on Pterygium Inflammation Discovers Association between Inflammatory Responses, Oxidative Stress, and Oxidative Phosphorylation
by Ye-Ah Kim, Yueun Choi, Tae Gi Kim, Jisu Jeong, Sanghyeon Yu, Taeyoon Kim, Kisung Sheen, Yoonsung Lee, Taesoo Choi, Yong Hwan Park, Min Seok Kang and Man S. Kim
Int. J. Mol. Sci. 2024, 25(9), 4789; https://doi.org/10.3390/ijms25094789 (registering DOI) - 27 Apr 2024
Abstract
A pterygium is a common conjunctival degeneration and inflammatory condition. It grows onto the corneal surface or limbus, causing blurred vision and cosmetic issues. Ultraviolet is a well-known risk factor for the development of a pterygium, although its pathogenesis remains unclear, with only [...] Read more.
A pterygium is a common conjunctival degeneration and inflammatory condition. It grows onto the corneal surface or limbus, causing blurred vision and cosmetic issues. Ultraviolet is a well-known risk factor for the development of a pterygium, although its pathogenesis remains unclear, with only limited understanding of its hereditary basis. In this study, we collected RNA-seq from both pterygial tissues and conjunctival tissues (as controls) from six patients (a total of twelve biological samples) and retrieved publicly available data, including eight pterygium samples and eight controls. We investigated the intrinsic gene regulatory mechanisms closely linked to the inflammatory reactions of pterygiums and compared Asian (Korea) and the European (Germany) pterygiums using multiple analysis approaches from different perspectives. The increased expression of antioxidant genes in response to oxidative stress and DNA damage implies an association between these factors and pterygium development. Also, our comparative analysis revealed both similarities and differences between Asian and European pterygiums. The decrease in gene expressions involved in the three primary inflammatory signaling pathways—JAK/STAT, MAPK, and NF-kappa B signaling—suggests a connection between pathway dysfunction and pterygium development. We also observed relatively higher activity of autophagy and antioxidants in the Asian group, while the European group exhibited more pronounced stress responses against oxidative stress. These differences could potentially be necessitated by energy-associated pathways, specifically oxidative phosphorylation. Full article
12 pages, 794 KiB  
Article
New Method to Estimate Rock Mass Deformation Modulus Based on BQ System
by Huishi Xue, Yanhui Song, Man Feng and Guanghong Ju
Appl. Sci. 2024, 14(9), 3736; https://doi.org/10.3390/app14093736 (registering DOI) - 27 Apr 2024
Abstract
The rock mass deformation modulus is one of the most important design parameters in a range of rock engineering applications. Its value is usually obtained directly through in situ testing or estimated indirectly on the basis of a rock mass quality classification system. [...] Read more.
The rock mass deformation modulus is one of the most important design parameters in a range of rock engineering applications. Its value is usually obtained directly through in situ testing or estimated indirectly on the basis of a rock mass quality classification system. Because in situ testing is generally costly, time-consuming, and presents operational difficulties, it cannot be carried out extensively, and many researchers have concentrated on developing indirect procedures to obtain information on the modulus of deformation, such as the RMR method, Q method, and GSI method. The purpose of this paper is to present a new system for estimating the rock mass deformation modulus called the BQ method, which is based on the BQ (basic quality) system. In this paper, the BQ system is first briefly reviewed, and then more than 60 in situ measurements from three large hydropower stations in China are used to develop a new relationship between BQ and the deformation modulus, based on a power function relationship. The paper also derives correlations based on the existing estimation formula and the relationship between BQ and other classification schemes, resulting in several recommended formulas for estimating the deformation modulus of a rock mass using the BQ method. Full article
(This article belongs to the Special Issue Rock Mass Characterization: Failure and Mechanical Behavior)
18 pages, 1732 KiB  
Article
The Effect of Wet and Dry Cycles on the Strength and the Surface Characteristics of Coromandel Lacquer Coatings
by Wenjia Liu, Ling Zhu, Varodi Anca Maria, Xinyou Liu and Jiufang Lv
Forests 2024, 15(5), 770; https://doi.org/10.3390/f15050770 (registering DOI) - 27 Apr 2024
Abstract
Research on the degradation mechanism of coating materials is crucial for the preservation of cultural heritage. The purpose of this study was to evaluate the protective effect of Coromandel coatings on wooden substrates by analyzing their dimensions, weight, adhesion strength, hydrophobicity, and glossiness. [...] Read more.
Research on the degradation mechanism of coating materials is crucial for the preservation of cultural heritage. The purpose of this study was to evaluate the protective effect of Coromandel coatings on wooden substrates by analyzing their dimensions, weight, adhesion strength, hydrophobicity, and glossiness. The results indicate that after five cycles, the radial moisture expansion rate of the wood specimen is 0.332%, while that of the lacquer specimen is 0.079%, representing 23.8% of the radial moisture expansion rate of untreated wood specimens. This performance is superior to that of the ash and pigment specimens. Across different experimental conditions, the change in the mass of the Coromandel specimens aligns with the trend in their dimensional changes, indicating that moisture absorption and desorption are the primary reasons for dimensional changes. The influence of temperature on mass and dimensional stability is significant only in terms of dry shrinkage rate. After wet and dry cycles at 40 °C, the adhesion strength of the Coromandel specimens decreases the most, with the ash specimens decreasing by 7.2%, the lacquer specimens by 3.2%, and the pigment specimens by 4.5%. Following wet and dry cycles at three different temperatures, the contact angle of the lacquer layers changes by less than 5%, with their contact angle values exceeding 120°. These data indicate that among the Coromandel coatings, the lacquer layer provides the best protection for the wooden substrate, while the ash coating is the most fragile. The degradation rate of the Coromandel specimens increases with rising temperatures. These findings emphasize the critical roles of humidity and temperature in protecting wooden coatings and aim to provide theoretical insights and practical significance for the preservation of wooden artifacts and the assessment of coating performance. Full article
14 pages, 1985 KiB  
Article
Optimizing Apricot Yield and Quality with Biostimulant Interventions: A Comprehensive Analysis
by Aurora Cirillo, Luana Izzo, Andrea Ciervo, Ivana Ledenko, Marco Cepparulo, Alfonso Piscitelli and Claudio Di Vaio
Horticulturae 2024, 10(5), 447; https://doi.org/10.3390/horticulturae10050447 (registering DOI) - 27 Apr 2024
Abstract
Biostimulant products are recognized for their ability to improve the agronomic parameters of plants and the qualitative and nutraceutical parameters of fruits and confer greater resistance to plants under abiotic and biotic stress conditions. In our study, we tested three different biostimulants on [...] Read more.
Biostimulant products are recognized for their ability to improve the agronomic parameters of plants and the qualitative and nutraceutical parameters of fruits and confer greater resistance to plants under abiotic and biotic stress conditions. In our study, we tested three different biostimulants on cultivar “Lady Cot” apricot plants: animal-derived protein hydrolysate, plant-derived protein hydrolysate, and one based on algae to evaluate their effects on improving the agronomic parameters of plants and fruit quality. The product that stood out for providing positive effects was the protein hydrolysate-based product, which increased plant production by 53.80% and yield efficiency by 56.38%. At the same time, it also increased the fruit’s diameter growth by approximately 8.3%, showing positive effects on fruit weight as well. The animal-derived protein hydrolysate also reduced acidity by 13.8% and showed a significant increase compared to the control in terms of total polyphenols. Additional research is scheduled to validate these results and ascertain which categories of biostimulant products are most effective in enhancing the agronomic, qualitative, and sensory characteristics of other apricot cultivars. Full article
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19 pages, 346 KiB  
Article
Estimating Market Power Exertion in the U.S. Beef Packing Industry: An Illustration of Data Aggregation Bias Using Simulated Data
by Jung Min Lee and Chanjin Chung
Sustainability 2024, 16(9), 3673; https://doi.org/10.3390/su16093673 (registering DOI) - 27 Apr 2024
Abstract
This study investigates data aggregation bias in estimating market power in the U.S. beef packing industry using New Empirical Industrial Organization (NEIO) models and shows empirical procedures that can alleviate the bias. Unlike many earlier studies in estimating market power exertion, our study [...] Read more.
This study investigates data aggregation bias in estimating market power in the U.S. beef packing industry using New Empirical Industrial Organization (NEIO) models and shows empirical procedures that can alleviate the bias. Unlike many earlier studies in estimating market power exertion, our study examines the data aggregation bias when market-level data are used in place of firm-level data and show how the bias could be reduced. We first derive data aggregation bias analytically, then empirically investigate the aggregation bias by estimating both firm and aggregate industry models. Because the firm-level data are not available, we use simulated data generated from the Monte Carlo simulation method. Hybrid models, combining limited firm-level data with aggregate data, are also estimated to illustrate how the aggregation bias could be reduced. Our results show that aggregate models with industry-level data tend to underestimate market power exertion in the U.S. beef packing industry, and the aggregation bias is statistically significant at the 1% level. Comparing results from hybrid models with firm-level estimates, we find that hybrid models reduce the bias but do not remove the aggregation bias significantly. The sensitivity analysis shows that market power estimate and aggregation bias are sensitive to functional forms. Full article
(This article belongs to the Special Issue Agribusiness and Rural Development)
13 pages, 2073 KiB  
Article
Fructosyl Amino Oxidase as a Therapeutic Enzyme in Age-Related Macular Degeneration
by Joris R. Delanghe, Jose Diana Di Mavungu, Koen Beerens, Jonas Himpe, Nezahat Bostan, Marijn M. Speeckaert, Henk Vrielinck, Anne Vral, Caroline Van Den Broeke, Manon Huizing and Elisabeth Van Aken
Int. J. Mol. Sci. 2024, 25(9), 4779; https://doi.org/10.3390/ijms25094779 (registering DOI) - 27 Apr 2024
Abstract
Age-related macular degeneration (AMD) is an age-related disorder that is a global public health problem. The non-enzymatic Maillard reaction results in the formation of advanced glycation end products (AGEs). Accumulation of AGEs in drusen plays a key role in AMD. AGE-reducing drugs may [...] Read more.
Age-related macular degeneration (AMD) is an age-related disorder that is a global public health problem. The non-enzymatic Maillard reaction results in the formation of advanced glycation end products (AGEs). Accumulation of AGEs in drusen plays a key role in AMD. AGE-reducing drugs may contribute to the prevention and treatment of AGE-related disease. Fructosamine oxidase (FAOD) acts on fructosyl lysine and fructosyl valine. Based upon the published results of fructosamine 3-kinase (FN3K) and FAOD obtained in cataract and presbyopia, we studied ex vivo FAOD treatment as a non-invasive AMD therapy. On glycolaldehyde-treated porcine retinas, FAOD significantly reduced AGE autofluorescence (p = 0.001). FAOD treatment results in a breakdown of AGEs, as evidenced using UV fluorescence, near-infrared microspectroscopy on stained tissue sections of human retina, and gel permeation chromatography. Drusen are accumulations of AGEs that build up between Bruch’s membrane and the retinal pigment epithelium. On microscopy slides of human retina affected by AMD, a significant reduction in drusen surface to 45 ± 21% was observed following FAOD treatment. Enzymatic digestion followed by mass spectrometry of fructose- and glucose-based AGEs (produced in vitro) revealed a broader spectrum of substrates for FAOD, as compared to FN3K, including the following: fructosyllysine, carboxymethyllysine, carboxyethyllysine, and imidazolone. In contrast to FN3K digestion, agmatine (4-aminobutyl-guanidine) was formed following FAOD treatment in vitro. The present study highlights the therapeutic potential of FAOD in AMD by repairing glycation-induced damage. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Retina Degeneration)
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18 pages, 4665 KiB  
Article
Decoding Evolution of Rubioideae: Plastomes Reveal Sweet Secrets of Codon Usage, Diagnostides, and Superbarcoding
by Kamil Ciborowski, Monika Szczecińska, Mateusz Maździarz, Jakub Sawicki and Łukasz Paukszto
Genes 2024, 15(5), 562; https://doi.org/10.3390/genes15050562 (registering DOI) - 27 Apr 2024
Abstract
Galium genus belongs to the Rubiaceae family, which consists of approximately 14,000 species. In comparison to its well-known relatives, the plastomes of the Galium genus have not been explored so far. The plastomes of this genus have a typical, quadripartite structure, but differ [...] Read more.
Galium genus belongs to the Rubiaceae family, which consists of approximately 14,000 species. In comparison to its well-known relatives, the plastomes of the Galium genus have not been explored so far. The plastomes of this genus have a typical, quadripartite structure, but differ in gene content, since the infA gene is missing in Galium palustre and Galium trfidum. An evaluation of the effectiveness of using entire chloroplast genome sequences as superbarcodes for accurate plant species identification revealed the high potential of this method for molecular delimitation within the genus and tribe. The trnE-UUC—psbD region showed the biggest number of diagnostides (diagnostic nucleotides) which might be new potential barcodes, not only in Galium, but also in other closely related genera. Relative synonymous codon usage (RSCU) appeared to be connected with the phylogeny of the Rubiaceae family, showing that during evolution, plants started preferring specific codons over others. Full article
(This article belongs to the Special Issue The Evolutionary Genetics and Genomics of Speciation)
18 pages, 6768 KiB  
Article
Data-Driven Assessment of the Impact of Hurricanes Ian and Nicole: Natural and Armored Dunes in the Aftermath of Hurricanes on Florida’s Central East Coast
by Kelly M. San Antonio, Daniel Burow, Hyun Jung Cho, Matthew J. McCarthy, Stephen C. Medeiros, Yao Zhou and Hannah V. Herrero
Remote Sens. 2024, 16(9), 1557; https://doi.org/10.3390/rs16091557 (registering DOI) - 27 Apr 2024
Abstract
Hurricanes Ian and Nicole caused devastating destruction across Florida in September and November 2022, leaving widespread damage in their wakes. This study focuses on the assessment of barrier islands’ shorelines, encompassing natural sand dunes and dune vegetation as well as armored dunes with [...] Read more.
Hurricanes Ian and Nicole caused devastating destruction across Florida in September and November 2022, leaving widespread damage in their wakes. This study focuses on the assessment of barrier islands’ shorelines, encompassing natural sand dunes and dune vegetation as well as armored dunes with man-made infrastructure such as seawalls. High-resolution satellite imagery from Planet was used to assess the impacts of these hurricanes on the beach shorelines of Volusia, Flagler, and St. Johns Counties on the Florida Central East Coast. Shorefront vegetation was classified into two classes. Normalized Difference Vegetation Index (NDVI) values were calculated before the hurricanes, one month after Hurricane Ian, one month after Hurricane Nicole, and one-year post landfall. LiDAR (Light Detection and Ranging) was incorporated to calculate vertical changes in the shorelines before and after the hurricanes. The results suggest that natural sand dunes were more resilient as they experienced less impact to vegetation and elevation and more substantial recovery than armored dunes. Moreover, the close timeframe of the storm events suggests a compound effect on the weakened dune systems. This study highlights the importance of understanding natural dune resilience to facilitate future adaptive management efforts because armored dunes may have long-term detrimental effects on hurricane-prone barrier islands. Full article
(This article belongs to the Special Issue Remote Sensing and Ecosystem Modeling for Nature-Based Solutions)
12 pages, 2215 KiB  
Review
Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis
by Greggory Myers, Yanan Sun, Yu Wang, Hajar Benmhammed and Shuaiying Cui
Genes 2024, 15(5), 563; https://doi.org/10.3390/genes15050563 (registering DOI) - 27 Apr 2024
Abstract
TR2 and TR4 (NR2C1 and NR2C2, respectively) are evolutionarily conserved nuclear orphan receptors capable of binding direct repeat sequences in a stage-specific manner. Like other nuclear receptors, TR2 and TR4 possess important roles in transcriptional activation or repression with developmental stage and tissue [...] Read more.
TR2 and TR4 (NR2C1 and NR2C2, respectively) are evolutionarily conserved nuclear orphan receptors capable of binding direct repeat sequences in a stage-specific manner. Like other nuclear receptors, TR2 and TR4 possess important roles in transcriptional activation or repression with developmental stage and tissue specificity. TR2 and TR4 bind DNA and possess the ability to complex with available cofactors mediating developmental stage-specific actions in primitive and definitive erythrocytes. In erythropoiesis, TR2 and TR4 are required for erythroid development, maturation, and key erythroid transcription factor regulation. TR2 and TR4 recruit and interact with transcriptional corepressors or coactivators to elicit developmental stage-specific gene regulation during hematopoiesis. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
20 pages, 1746 KiB  
Article
Vulnerability of Farmer Households to Climate Change in Rocky Desertification Areas—A Case Study of Guizhou Province
by Xian Liu, Shiwei Liu, Rutong Wang, Hanya Tang, Feng Zhang, Luyao Jia and Xizao Sun
Land 2024, 13(5), 582; https://doi.org/10.3390/land13050582 (registering DOI) - 27 Apr 2024
Abstract
Climate change significantly impacts the livelihoods of farmer households. Particularly vulnerable areas, both economically and environmentally, face significant threats from climate change. This study developed a framework to assess household-level vulnerability to climate change by integrating the Exposure-Sensitivity-Resilience Analysis (ESRA) and Sustainable Livelihoods [...] Read more.
Climate change significantly impacts the livelihoods of farmer households. Particularly vulnerable areas, both economically and environmentally, face significant threats from climate change. This study developed a framework to assess household-level vulnerability to climate change by integrating the Exposure-Sensitivity-Resilience Analysis (ESRA) and Sustainable Livelihoods Analysis (SLA) frameworks. Using Gui-Zhou Province as the study area, the study examined whether livelihood vulnerability differs among various types of farmer households in economically and environmentally vulnerable areas and identified the main factors contributing to vulnerability. Results indicate significant differences in livelihood vulnerability among the three household types, with pure agricultural households (PAH) being the most vulnerable due to high exposure, sensitivity, and low adaptive capacity. Further analysis revealed minor differences in sensitivity but significant differences in adaptive capacity among the three farmer categories. In terms of sensitivity, all three farmer household categories exhibit high sensitivity to water, housing, and agricultural production. Regarding adaptive capacity, significant differences in human and financial capital exist among the three household types, with off-farm households (OFH) possessing the highest adaptive capacity due to their substantial human and financial capital. Further research identified high exposure and low adaptive capacity as the primary causes of livelihood vulnerability, noting no significant difference in the main contributing factors among the three types of farmer households. Common factors contributing to the livelihood vulnerability of farmer households include agricultural cooperatives, labor capacity, temperature changes, drought frequency changes, precipitation changes, agricultural insurance, and losses in agricultural production. Overall, the proposed livelihood vulnerability framework offers guidance for analyzing the vulnerability of farmer households in areas with both economic and environmental vulnerabilities under climate change. Concurrently, tailored measures to reduce farmer households’ livelihood vulnerability should be developed for different household types, considering the local climatic, geographic, and socioeconomic conditions. Full article
15 pages, 1106 KiB  
Article
Dual-Criteria Decision Analysis by Multiphotonic Effects in Nanostructured ZnO
by Victor Manuel Garcia-de-los-Rios, Jose Alberto Arano-Martinez, Martin Trejo-Valdez, Mónica Araceli Vidales-Hurtado, Gina Gallegos-García and Carlos Torres-Torres
Micromachines 2024, 15(5), 579; https://doi.org/10.3390/mi15050579 (registering DOI) - 27 Apr 2024
Abstract
Simultaneous interrogation of pump and probe beams interacting in ZnO nanostructures of a two-wave mixing is proposed for dual-path data processing of optical signals by nonlinear optical effects. An enhancement in third-order nonlinear optical properties was exhibited by Al-doped ZnO thin films. Multiphoton [...] Read more.
Simultaneous interrogation of pump and probe beams interacting in ZnO nanostructures of a two-wave mixing is proposed for dual-path data processing of optical signals by nonlinear optical effects. An enhancement in third-order nonlinear optical properties was exhibited by Al-doped ZnO thin films. Multiphoton absorption and nonlinear refraction were explored by the z-scan technique at 532 nm with nanosecond pulses. The evolution of the optical Kerr effect in the ZnO thin films was analyzed as a function of the incorporation of Al in the sample by a vectorial two-wave mixing method. Electrical and photoconductive effects were evaluated to further characterize the influence of Al in the ZnO solid samples. Potential applications of nonlinear optical parameters for encoding and encrypting information in light can be envisioned. Full article
(This article belongs to the Special Issue Nanomaterials Photonics)
18 pages, 25889 KiB  
Article
Two-Decadal Glacier Changes in the Astak, a Tributary Catchment of the Upper Indus River in Northern Pakistan
by Muzaffar Ali, Qiao Liu and Wajid Hassan
Remote Sens. 2024, 16(9), 1558; https://doi.org/10.3390/rs16091558 (registering DOI) - 27 Apr 2024
Abstract
Snow and ice melting in the Upper Indus Basin (UIB) is crucial for regional water availability for mountainous communities. We analyzed glacier changes in the Astak catchment, UIB, from 2000 to 2020 using remote sensing techniques based on optical satellite images from Landsat [...] Read more.
Snow and ice melting in the Upper Indus Basin (UIB) is crucial for regional water availability for mountainous communities. We analyzed glacier changes in the Astak catchment, UIB, from 2000 to 2020 using remote sensing techniques based on optical satellite images from Landsat and ASTER digital elevation models. We used a surface feature-tracking technique to estimate glacier velocity. To assess the impact of climate variations, we examined temperature and precipitation anomalies using ERA5 Land climate data. Over the past two decades, the Astak catchment experienced a slight decrease in glacier area (−1.8 km2) and the overall specific mass balance was −0.02 ± 0.1 m w.e. a−1. The most negative mass balance of −0.09 ± 0.06 m w.e. a−1 occurred at elevations between 2810 to 3220 m a.s.l., with a lesser rate of −0.015 ± 0.12 m w.e. a−1 above 5500 m a.s.l. This variation in glacier mass balance can be attributed to temperature and precipitation gradients, as well as debris cover. Recent glacier mass loss can be linked to seasonal temperature anomalies at higher elevations during winter and autumn. Given the reliance of mountain populations on glacier melt, seasonal temperature trends can disturb water security and the well-being of dependent communities. Full article

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