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Active mitochondrial respiration in cancer: a target for the drug

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Abstract

The relative contribution of mitochondrial respiration and subsequent energy production in malignant cells has remained controversial to date. Enhanced aerobic glycolysis and impaired mitochondrial respiration have gained more attention in the metabolic study of cancer. In contrast to the popular concept, mitochondria of cancer cells oxidize a diverse array of metabolic fuels to generate a majority of the cellular energy by respiration. Several mitochondrial respiratory chain (MRC) subunits’ expressions are critical for the growth, metastasis, and cancer cell invasion. Also, the assembly factors, which regulate the integration of individual MRC complexes into native super-complexes, are upregulated in cancer. Moreover, a series of anti-cancer drugs function by inhibiting respiration and ATP production. In this review, we have specified the roles of mitochondrial fuels, MRC subunits, and super-complex assembly factors that promote active respiration across different cancer types and discussed the potential roles of MRC inhibitor drugs in controlling cancer.

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Acknowledgements

We acknowledge SERB, CSIR, and GLA University, India.

Funding

This study was supported by a Grant (ECR/2016/001127) from Science and Engineering Research Board, India to AG and by a Calcutta University BI Grant to AG and CSIR Grant (No: 09/028(1127)/2019-EMR-I) to MB. We are also thankful to GLA University, Mathura for funding MR.

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019, India

    Minakshi Bedi & Alok Ghosh

  2. Department of Biophysics, Bose Institute, P 1/12, CIT Scheme VII M, Kolkata, West Bengal, 700054, India

    Manju Ray

  3. Department of Chemistry, Institute of Applied Science & Humanities GLA University Mathura, 17km Stone, NH-2, Mathura-Delhi Road, Mathura, UP, 281 406, India

    Manju Ray

Authors
  1. Minakshi Bedi
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  2. Manju Ray
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  3. Alok Ghosh
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Contributions

AG conceptualized this topic. MR added her valuable comments. AG and MB collectively wrote this manuscript.

Corresponding author

Correspondence to Alok Ghosh.

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Bedi, M., Ray, M. & Ghosh, A. Active mitochondrial respiration in cancer: a target for the drug. Mol Cell Biochem 477, 345–361 (2022). https://doi.org/10.1007/s11010-021-04281-4

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