Enantioselective reduction of ketones by borane catalysed by oxazaphospholidine oxides
Chiral oxazaphospholidine oxides efficiently catalyse the enantioselective reduction of ketones by borane with ee up to 94%:
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Asymmetric catalysis as a method for the synthesis of chiral organophosphorus compounds
2014, Tetrahedron AsymmetryCitation Excerpt :The biosynthesis of phosphorus compounds was carried out using various yeasts, microscopic fungi, and bacteria that are sources of biocatalysts which can be isolated and used separately. The reduction of ketones with Saccharomyces cerevisiae, that is, Baker’s yeast, is the most studied and widely used method of bioconversion, because this biocatalyst is accessible and universal, and the process is easily realizable.76–90 Yeast-catalyzed asymmetric reduction of diethyl 2-oxoalkylphosphonates 124 and 126, respectively, led to 2-hydroxyalkylphosphonates 125 and 127, 128 obtained in good yields and with enantiopurity as high as about 97–100%.76,84
3.17 Synthetically Derived Auxiliaries: Phosphorus Derivatives
2012, Comprehensive ChiralityAsymmetric carbonyl reduction with borane catalyzed by chiral phosphinamides derived from L-amino acid
2003, Tetrahedron Asymmetry