Enantioselective reduction of ketones by borane catalysed by oxazaphospholidine oxides

doi:10.1016/0040-4039(95)02078-0

Tetrahedron Letters

Volume 37, Issue 1, 1 January 1996, Pages 39-42

https://doi.org/10.1016/0040-4039(95)02078-0 Get rights and content

Abstract

New enantioselective catalysts for the asymmetric reduction of ketones by borane are described. Easily prepared by oxidation of chiral oxazaphospholidines, these compounds increase sensitively the reduction rate of numerous ketones and induce ee's up to 94% in the case of the 2-chloroacetophenone.

Chiral oxazaphospholidine oxides efficiently catalyse the enantioselective reduction of ketones by borane with ee up to 94%:

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Enantioselective reduction of ketones by borane catalysed by oxazaphospholidine oxides

Abstract

Tetrahedron Lett.

Tetrahedron Lett.

Tetrahedron: Asymmetry

Tetrahedron Lett.

J. Chem. Soc., Chem. Commun.

J. Chem. Soc., Chem. Commun.

J. Chem. Soc., Perkin Trans. 1

J. Am. Chem. Soc.

J. Am. Chem. Soc.