This paper delves into the realm of human activity recognition (HAR) by leveraging the capabilities of Siamese neural networks (SNNs), focusing on the comparative effectiveness of contrastive and triplet learning approaches. Against the backdrop of HAR’s growing importance in healthcare, sports, and smart environments, the need for advanced models capable of accurately recognizing and classifying complex human activities has become paramount. Addressing this, we have introduced a Siamese network architecture integrated with convolutional neural networks (CNNs) for spatial feature extraction, bidirectional LSTM (Bi-LSTM) for temporal dependency capture, and attention mechanisms to prioritize salient features. Employing both contrastive and triplet loss functions, we meticulously analyze the impact of these learning approaches on the network’s ability to generate discriminative embeddings for HAR tasks. Through extensive experimentation, the study reveals that Siamese networks, particularly those utilizing triplet loss functions, demonstrate superior performance in activity recognition accuracy and F1 scores compared with baseline deep learning models. The inclusion of a stacking meta-classifier further amplifies classification efficacy, showcasing the robustness and adaptability of our proposed model. Conclusively, our findings underscore the potential of Siamese networks with advanced learning paradigms in enhancing HAR systems, paving the way for future research in model optimization and application expansion. Full article

Recreational waterbodies with high levels of faecal indicator bacteria (FIB) pose health risks and are an ongoing challenge for urban-lake managers. Lake Burley Griffin (LBG) in the Australian Capital city of Canberra is a popular site for water-based recreation, but analyses of seasonal and long-term patterns in enterococci that exceed alert levels (>200 CFU per 100 mL, leading to site closures) are lacking. This study analysed enterococci concentrations from seven recreational sites from 2001–2021 to examine spatial and temporal patterns in exceedances during the swimming season (October–April), when exposure is highest. The enterococci concentrations varied significantly across sites and in the summer months. The frequency of the exceedances was higher in the 2009–2015 period than in the 2001–2005 and 2015–2021 periods. The odds of alert-level concentrations were greater in November, December, and February compared to October. The odds of exceedance were higher at the Weston Park East site (swimming beach) and lower at the Ferry Terminal and Weston Park West site compared to the East Basin site. This preliminary examination highlights the need for site-specific assessments of environmental and management-related factors that may impact the public health risks of using the lake, such as inflows, turbidity, and climatic conditions. The insights from this study confirm the need for targeted monitoring efforts during high-risk months and at specific sites. The study also advocates for implementing measures to minimise faecal pollution at its sources. Full article

We present a two-country model (North and South) that describes the phenomenon of offshoring and reshoring. The model is a continuous time-controlled Markov chain with binary states. The main trade-off involves production costs and transaction costs between one country and another. In the first part of this paper, we identify the key parameters of the model: the difference in unit production costs between the two countries considered, the marginal cost of transitioning between countries, and the incentive paid by the North country to all companies that have not relocated at the end of the planning interval. The final goal of our paper is to understand how national tax incentives can influence this process. Full article

The selection of growth substrate geometries for the mechanical dry transfer of carbon nanotubes to device substrates depends on the precision of the assembly equipment. Since these geometries play a decisive role in the overall efficiency of the process, an investigation of the most important geometry parameters is carried out. The substrate geometry affects the number of carbon nanotubes suspended during the growth process and the speed of mechanical assembly at the same time. Since those two criteria are interlinked and affect productivity, a meta-model for the growth and selection of the nanotubes is simulated and a time study of the resulting assembly motions is subsequently performed. The geometry parameters are then evaluated based on the total number of suspended carbon nanotubes and the throughput rate, measured in transfers per hour. The accuracy specifications are then taken into account. Depending on the overall accuracy that can be achieved, different offset angles and overlaps between the growth and receiving substrate can be reached, which affect productivity differently for different substrate geometries. To increase the overall productivity, growth substrate designs are adapted to allow fully automated operation. This measure also reduces the frequency of substrate exchanges once all carbon nanotubes have been harvested. The introduction of substrates with multiple, polygonally arranged edges increases the total number of nanotubes that can be harvested. The inclusion of polygonally arranged edges in the initial analysis shows a significant increase in overall productivity. Full article

Fibrous dysplasia (FD) poses a therapeutic challenge due to the dysregulated extracellular matrix (ECM) accumulation within affected bone tissues. In this study, we investigate the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃) in managing FD by examining its effects on FD-derived cells in vitro. Our findings demonstrate that 1,25(OH)₂D₃ treatment attenuates the pro-fibrotic phenotype of FD-derived cells by suppressing the expression of key pro-fibrotic markers and inhibiting cell proliferation and migration. Moreover, 1,25(OH)₂D₃ enhances mineralization by attenuating pre-osteoblastic cellular hyperactivity and promoting maturation towards an osteocytic phenotype. These results offer valuable insights into potential treatments for FD, highlighting the role of 1,25(OH)₂D₃ in modulating the pathological properties of FD-derived cells. Full article

This study rigorously investigates the intricate dynamics between Corporate Social Responsibility (CSR), quantified through Environmental, Social, and Governance (ESG) scores, and financial performance (FP), measured via the return on assets (ROA) and return on equity (ROE), within the UK banking sector. Our analysis is based on a comprehensive dataset from Bloomberg. This research encapsulates data from 32 banks publicly listed on the London Stock Exchange over a six-year span from 2017 to 2022. Employing panel data regression models while controlling leverage and bank size, we delve into the relationship between banks’ CSR engagements, as reflected in their ESG scores, and their financial outcomes. Our findings indicate a negative correlation between the ESG score and both the ROA and ROE, suggesting that elevated CSR commitments may inversely impact short-term financial returns. This finding not only challenges prevailing narratives within the sector but also fosters a crucial discourse on the balance between ethical banking practices and profitability. The implications of this research study are manifold, extending to policymakers, banking executives, and investors, suggesting a revaluation of CSR strategies in alignment with long-term value creation and sustainable banking. This study not only enriches academic discourse on CSR within the financial sector but also serves as a beacon for future inquiries into the evolving landscape of responsible banking, advocating for a nuanced understanding of CSR’s role in shaping the financial and ethical contours of the banking industry. Full article

In recent years, satellite communication systems (SCSs) have rapidly developed in terms of their role and capabilities, promoted by advancements in space launch technologies. However, this rapid development has also led to the emergence of significant security vulnerabilities, demonstrated through real-world targeted attacks such as AcidRain and AcidPour that demand immediate attention from the security community. In response, various countermeasures, encompassing both technological and policy-based approaches, have been proposed to mitigate these threats. However, the multitude and diversity of these proposals make their comparison complex, requiring a systemized view of the landscape. In this paper, we systematically categorize and analyze both attacks and defenses within the framework of confidentiality, integrity, and availability, focusing on specific threats that pose substantial risks to SCSs. Furthermore, we evaluate existing countermeasures against potential threats in SCS environments and offer insights into the security policies of different nations, recognizing the strategic importance of satellite communications as a national asset. Finally, we present prospective security challenges and solutions for future SCSs, including full quantum communication, AI-integrated SCSs, and standardized protocols for the next generation of terrestrial–space communication. Full article

In this study, TiO₂/P, K-containing grapefruit peel biochar (TiO₂/P, K-PC) composites were synthesized in situ biomimetically using grapefruit peel as the bio-template and carbon source and tetrabutyl titanate as the titanium source. This was achieved using the two-step rotary impregnation–calcination method. Adjusting the calcination temperature of the sample in an air atmosphere could regulate the mass ratio of TiO₂ to carbon. The prepared samples were subjected to an analysis of their compositions, structures, morphologies, and properties. It demonstrated that the prepared samples were complexes of anatase TiO₂ and P, K-containing carbon, with the presence of graphitic carbon. They possessed a unique morphological structure with abundant pores and a large surface area. The grapefruit peel powder played a crucial role in the induction and assembly of TiO₂/P, K-PC composites. The sample PCT-400-550 had the best photocatalytic activity, with the degradation rate of RhB, MO, and MB dye solutions reaching more than 99% within 30 min, with satisfactory cyclic stability. The outstanding photocatalytic activity can be credited to its unique morphology and the efficient collaboration between TiO₂ and P, K-containing biochar. Full article

As part of a long-term campaign to document, study, and conserve the Heroes tapestries from The Cloisters collection at The Metropolitan Museum of Art, organic colorant analysis of Julius Caesar (accession number 47.101.3) was performed. Analysis with liquid chromatography–quadrupole time-of-flight mass spectrometry (LC-qToF-MS) revealed the presence of several multiply chlorinated xanthones produced only by certain species of lichen. Various lichen dye sources have been documented in the literature for centuries and are classified as either ammonia fermentation method (AFM) or boiling water method (BWM) dyes based on their method of production. However, none of these known sources produce the distinctive metabolites present in the tapestry. LC-qToF-MS was also used to compare the chemical composition of the dyes in the tapestry with that of several species of crustose lichen. Lichen metabolites, including thiophanic acid and arthothelin, were definitively identified in the tapestry based on comparison with lichen xanthone standards and a reference of Lecanora sulphurata, confirming the presence of a lichen source. This finding marks the first time that lichen xanthones have been identified in a historic object and the first evidence that BWM lichen dyes may have been used prior to the eighteenth century. Full article

Increased performance with reduced overall cost, and precise design and optimization of launch systems are critical to affordability. In this respect, the use of hybrid motors has increased to ease handling based on motor selection. In the current study, the launch vehicle’s performance is enhanced by incorporating a hybrid rocket motor into the last stage and optimized using particle swarm optimization to develop a six-degrees-of-freedom tool. This modification aims to increase payload placement flexibility, facilitate handling, and reduce costs. Thanks to the interactive subsystems within this research, this innovative study more comprehensively considers the launch vehicle trajectory design problem, allowing the simultaneous consideration of the effect of launch vehicle geometry along with other parameters in the system. In this context, the proposed method is applied to the Minotaur-I launch vehicle, and contributions of the detailed design and optimization are presented. Optimization results show that the percentage differences between these models for the original vehicle were observed to be 11.55% in velocity and 8.02% in altitude. However, there were differences of 10.06% and 48.8%, 15.8% and 23.2%, and 19.5% and 78.9% in altitudes and velocities when the center of gravity and moment of inertia changes were neglected, and constant aerodynamic coefficients were assumed, respectively. In all these cases, it was observed that the flight path angle was not close to zero. Moreover, the same mission was achieved by the launch vehicle with the optimized hybrid last stage and the propulsion performance was increased by about 7.64% based on the specific impulse and total impulse-over-weight ratio. Full article

Optical coherence tomography (OCT) is widely used to probe retinal structure and function. This study investigated the outer retina band (ORB) pattern and reflective intensity for the region between bands 2 and 3 (Dip) in three mouse models of inherited retinal degeneration (Rs1KO, TTLL5KO, RPE65KO) and in human AMD patients from the A2A database. OCT images were manually graded, and reflectivity signals were used to calculate the Dip ratio. Qualitative analyses demonstrated the progressive merging band 2 and band 3 in all three mouse models, leading to a reduction in the Dip ratio compared to wildtype (WT) controls. Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. The degree of anatomical rescue in these mice was highly correlated with level of transgenic RS1 expression and with the restoration of ERG b-wave amplitudes. While the inner retinal cavity was significantly enlarged in dark-adapted Rs1KO mice, the Dip ratio was not altered. A reduction of the Dip ratio was also detected in AMD patients compared with healthy controls and was also positively correlated with AMD severity on the AMD score. We propose that the ORB and Dip ratio can be used as non-invasive early biomarkers for retina health, which can be used to probe therapeutic gene expression and to evaluate the effectiveness of therapy. Full article

In response to the high performance requirements of pulse width modulation (PWM) converters in grid-connected power systems, H-Infinity (H∞) control has attracted significant research interest due to its robustness against parameter variations and external disturbances. In this work, an advanced robust H∞ control is proposed for a grid-connected three-phase PWM rectifier. A two-level control strategy is adopted, where cascaded H∞ controllers are designed to simultaneously regulate the DC bus voltage and input currents even under load disturbances and non-ideal grid conditions. As a result, unit power factor, stable DC bus voltage, and sinusoidal input currents with lower harmonics can be accurately achieved. The design methodology and stability of the proposed controller are verified through a comprehensive analysis. Simulation tests and experimental implementation on a dSPACE 1103 board demonstrate that the proposed control scheme can effectively enhance disturbance rejection performance under various operating conditions. Full article

In the context of the rapid development of the Internet of Vehicles, virtual reality, automatic driving and the industrial Internet, the terminal devices in the network show explosive growth. As a result, more and more information is generated from the edge of the network, which makes the data throughput increase dramatically in the mobile communication network. As the key technology of the fifth-generation mobile communication network, mobile edge caching technology which caches popular data to the edge server deployed at the edge of the network avoids the data transmission delay of the backhaul link and the occurrence of network congestion. With the growing scale of the network, distributing hot data from cloud servers to edge servers will generate huge energy consumption. To realize the green and sustainable development of the communication industry and reduce the energy consumption of distribution of data that needs to be cached in edge servers, we make the first attempt to propose and solve the problem of edge caching data distribution with minimum energy consumption (ECDDMEC) in this paper. First, we model and formulate the problem as a constrained optimization problem and then prove its NP-hardness. Subsequently, we design a greedy algorithm with computational complexity of $O\left(n^2\right)$ to solve the problem approximately. Experimental results show that compared with the distribution strategy of each edge server directly requesting data from the cloud server, the strategy obtained by the algorithm can significantly reduce the energy consumption of data distribution. Full article

Wildland fire dispatchers play a key role in wildland fire management and response organization; however, to date, wildland fire studies have largely focused on the physical hazards and, to a lesser extent, mental health hazards of wildland firefighting operational personnel, and dispatcher studies have primarily focused on 911 and police dispatchers. Studies of other dispatchers have provided some limited insight into potential strains impacting this workforce, including work-related fatigue, burnout, and traumatic exposure. However, the specific job hazards that are faced by wildland fire dispatchers are poorly understood. In 2023, we conducted a cross-sectional survey of 510 wildland fire dispatchers with questions about their occupational health, general health, and well-being. We used validated screening instruments to measure the rates of anxiety, depression, PTSD, and suicidal thoughts and ideation. Here, we also present the results of mental health and trauma exposure questions that were asked as part of a larger survey. We found that demographic factors were significant indicators of anxiety, depression, and binge/restrictive eating. Our data indicate that rates of anxiety, depression, PTSD, and suicidal thoughts and ideation are significantly higher for both the wildland fire dispatching workforce and other emergency responder populations than those of the general United States population. Full article

Citizen science is an effective tool that unites ordinary citizens and scientists for a common cause. In particular, this tool enables ordinary citizens to participate in research and increases the likelihood of generating new knowledge. It is seen as the democratization of science. It is mainly applied in developed countries, and citizens usually help obtain environmental data with emerging technologies. However, training citizens to obtain good-quality data is one of the most significant challenges. It is also important to involve citizens in other phases, such as data analysis, discussion, and knowledge generation. Citizen science can be a tool for integrating different groups in science to promote social inclusion, including environmental, agricultural, earth, and life sciences. Thus, citizen science can contribute to education, sustainability, and climate change mitigation. Full article

Chronic pain in the vulnerable phase of emerging adulthood is associated with severe life impairments. The current healthcare system has no suitable treatments for young people. A new multimodal inpatient and app-supported treatment for young people with chronic pain counteracts this. The study examines the effectiveness of this new treatment. Our mixed-methods design combined qualitative and quantitative evaluations. The sample comprised N = 44 patients (18–25 years) who took part in the new treatment. The quantitative data showed a reduced degree of pain severity, pain-related and emotional impairments, and an improved quality of life. The qualitative data showed that several components of the new treatment were particularly important to the young adults: individuality and taking the patient seriously, group therapy with peers, individual therapies (psychological, medical), life counselling, and sports. Results support the individual and objective success of a new inpatient pain treatment applied during emerging adulthood. Full article

Lost-wax glass casting, an esteemed yet technically demanding art form, traditionally relies on specialized, costly kiln equipment, presenting significant barriers to artists regarding equipment affordability, energy efficiency, and the technical mastery required for temperature control. Therefore, this study introduces an innovative approach by integrating a microwave kiln with standard household microwave ovens, thus facilitating the lost-wax glass casting process. This methodological adaptation allows artists to employ readily available home appliances for glass creation, significantly reducing the process’s cost and complexity. Our experimental investigations reveal that, by using a 500W household microwave oven for heating, the silicon carbide (SiC) in microwave kilns can efficiently absorb microwave energy, allowing the kilns to reach temperatures exceeding 700 °C, a critical threshold for casting glass softening. We further demonstrate that by adjusting the number of heating cycles, producing high-quality, three-dimensional(3D) glass artworks is feasible, even for large-scale projects. In addition, the microwave kiln can be used as an effective cooling tool to uniformly cool the formed casting glass. This study presents a possible alternative to conventional kiln technology and marks a paradigm shift in glassmaking, offering a more accessible and sustainable avenue for artists and practitioners. Full article

Background: To achieve zero leprosy cases in Santa Cruz, Bolivia, we designed a community-based active detection and provision of single-dose rifampicin post-exposure prophylaxis (SDR-PEP) to household contacts with new leprosy patients. Methods: From July to August 2021, we assessed the current knowledge, attitude, and practices through structured interviews and focus group discussions with community representatives and health staff. This was followed by sensitization sessions, the training of health staff, and the reinforcement of referral mechanisms. Teams, including health staff and community volunteers, visited all new leprosy patients detected in 2021–2023 and household contacts. Results: Among 115 community representatives, knowledge about leprosy etiology was attributed to non-biological factors (74%); fear accounted for 77%, and access to care was perceived as weak (74%), but the outlook was improved by SDR-PEP (80%). Among the 217 health staff interviewed, the programmatic barriers identified were a lack of referral feedback (67%), limited supplies for diagnosis and prevention, and ineffective training (64%). We visited 70 new patients and 258 household contacts. The median age in household contacts was 25 years old; 49% were women, 98% were eligible for SDR-PEP, and all who were eligible accepted it. Those who were non-eligible included one tuberculosis patient and six newly detected leprosy patients (23‰). Conclusions: A community-based intervention was successful in Santa Cruz, Bolivia. Misbeliefs and a lack of knowledge were identified as barriers. Programmatic components should be reinforced for SDR-PEP extension. Full article

Background: In Nigeria, most children with tuberculosis (TB) present at primary health clinics where there are limited personnel skilled in collecting appropriate respiratory specimens from those who cannot produce sputum. KNCV Nigeria, in collaboration with the National Tuberculosis Control Program, implemented a modified simple, one-step (SOS), stool-based Xpert MTB/RIF method for diagnosis of TB in children who cannot expectorate sputum. We evaluated the impact of its implementation on childhood TB diagnosis. Method: A cross-sectional study was conducted across 14 selected states using secondary data of children presumed to have TB. Stool was collected from children presumed to have TB and processed using Xpert. Result: Out of 52,117 presumptive TB cases, 52% were male and 59.7% were under 5 years old. A total of 2440 (5%) cases were diagnosed with TB, and 2307 (95%) were placed on treatment. Annual TB notifications increased significantly after the introduction of the stool-based Xpert test when compared to those in the pre-implementation period. Increasing contributions from stool testing were observed throughout the implementation period, except in 2020 during the COVID-19 era. Overall, stool Xpert testing improved childhood TB notification in the studied states. Interventions aimed at awareness creation, capacity building, and active case finding improved the performance of the test. Full article

This article draws on case studies or ‘microhistories’ from the author’s own research to explore the ethical responsibility of family historians to represent the experiences of those whose lives have been ‘hidden from history’, and in particular the lives of one’s female ancestors, as a way of correcting the omissions and erasures of official histories. It also discusses the ethical dilemmas posed by the discovery that one’s ancestors were involved in activities that are now regarded as morally suspect, such as profiting from the ownership of slaves. Finally, the article debates ethical arguments about respecting the rights of the dead to privacy. Full article

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characterize this disease in order to identify efficient diagnostic/prognostic biomarkers. Since microRNAs (miRNAs) contribute to oncogenesis and metastasis formation in PDAC, they are considered potential candidates for fulfilling this task. In this work, the levels of two miRNA subsets (involved in chemoresistance or with oncogenic/tumor suppressing functions) were investigated in a panel of PDAC cell lines and liquid biopsies of a small cohort of patients. We used RT-qPCR and droplet digital PCR (ddPCR) to measure the amounts of cellular- and vesicle-associated, and circulating miRNAs. We found that both PDAC cell lines, also after gemcitabine treatment, and patients showed low amounts of cellular-and vesicle-associated miR-155-5p, compared to controls. Interestingly, we did not find any differences when we analyzed circulating miR-155-5p. Furthermore, vesicle-related miR-27a-3p increased in cancer patients compared to the controls, while circulating let-7a-5p, miR-221-3p, miR-23b-3p and miR-193a-3p presented as dysregulated in patients compared to healthy individuals. Our results highlight the potential clinical significance of these analyzed miRNAs as non-invasive diagnostic molecular tools to characterize PDAC. Full article

Nanostructured lipid carriers (NLCs) have the potential to increase the bioavailability and reduce the side effects of docetaxel (DTX). However, only a small fraction of nanoparticles given intravenously can reach a solid tumor. In situ-forming gels combined with nanoparticles facilitate local administration and promote drug retention at the tumor site. Injectable hydrogels based on poloxamer 407 are excellent candidates for this hybrid nanoparticle–hydrogel system because of their thermoresponsive behavior and biocompatibility. Therefore, this work aimed to develop injectable poloxamer hydrogels containing NLCs for intratumoral delivery of DTX. To ensure sterility, the obtained hydrogels were autoclaved (121 °C for 15 min) after preparation. Then, the incorporation of NLCs into the poloxamer hydrogels and the impact of steam sterilization on the nanocomposite hydrogels were evaluated concerning sol–gel transition, injectability, and physicochemical stability. All formulations were extruded through the tested syringe–needle systems with acceptable force (2.2–13.4 N) and work (49.5–317.7 N·mm) of injection. Following steam sterilization, injection became easier in most cases, and the physicochemical properties of all hydrogels remained practically unchanged according to the spectroscopical and thermal analysis. The rheological evaluation revealed that the nanocomposite hydrogels were liquid at 25 °C and underwent rapid gelation at 37 °C. However, their sterilized counterparts gelled at 1–2 °C above body temperature, suggesting that the autoclaving conditions employed had rendered these nanocomposite hydrogels unsuitable for local drug delivery. Full article