The 2023 MDPI Annual Report has
been released!
 
19 pages, 5401 KiB  
Article
Enhancing Root Distribution, Nitrogen, and Water Use Efficiency in Greenhouse Tomato Crops Using Nanobubbles
by Fernando del Moral Torres, Rafael Hernández Maqueda and David Erik Meca Abad
Horticulturae 2024, 10(5), 463; https://doi.org/10.3390/horticulturae10050463 (registering DOI) - 01 May 2024
Abstract
The aim of this work was to determine the effect of saturating the irrigation solution with air (MNBA) or oxygen nanobubbles (MNBO) on relevant agronomic, productive, and postharvest parameters of tomato crops (Solanum lycopersicum L.) in greenhouses. As a control, conventional management [...] Read more.
The aim of this work was to determine the effect of saturating the irrigation solution with air (MNBA) or oxygen nanobubbles (MNBO) on relevant agronomic, productive, and postharvest parameters of tomato crops (Solanum lycopersicum L.) in greenhouses. As a control, conventional management was established, without nanobubbles, under the best possible agronomic conditions used in commercial greenhouses in southeastern Spain. No significant differences were found in the soil properties analysed or in the ionic concentration of the pore water extracted with Rhizon probes. Both MNBA and MNBO modified the root distribution and improved the N uptake efficiency and field water uptake efficiency compared to the control. MNBA had the highest harvest index. The total or marketable production was not affected, although it did increase the overall size of the fruit and the earliness with which they were produced compared to the control. MNBA significantly decreased titratable acidity and soluble solids content compared to the control in the last harvests. Both nanobubble treatments improved postharvest storage under room-temperature (20–25 °C) conditions. Full article
(This article belongs to the Section Vegetable Production Systems)
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13 pages, 677 KiB  
Article
Good Health-Related Quality of Life in Older Patients One Year after mTBI despite Incomplete Recovery: An Indication of the Disability Paradox?
by Sophie M. Coffeng, Amaal Eman Abdulle, Harm J. van der Horn, Myrthe E. de Koning, Jan C. ter Maaten, Jacoba M. Spikman and Joukje van der Naalt
J. Clin. Med. 2024, 13(9), 2655; https://doi.org/10.3390/jcm13092655 (registering DOI) - 01 May 2024
Abstract
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing population, but studies on long-term outcomes and quality of life are scarce. Our aim was to determine the health-related quality of life (HRQoL) in OA-mTBI one year after injury [...] Read more.
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing population, but studies on long-term outcomes and quality of life are scarce. Our aim was to determine the health-related quality of life (HRQoL) in OA-mTBI one year after injury and to assess the early predictors of HRQoL. Methods: Data from a prospective follow-up study of 164 older (≥60 years) and 289 younger mTBI patients (<60 years) admitted to the emergency department were analyzed. Post-traumatic complaints, emotional distress and coping were evaluated 2 weeks post-injury using standardized questionnaires. At 12 months post-injury, HRQoL and functional recovery were determined with the abbreviated version of the World Health Organization Quality of Life scale and Glasgow Outcome Scale Extended (GOSE), respectively. Results: One year post-injury, 80% (n = 131) of the OA-mTBI rated their HRQoL as “good” or “very good”, which was comparable to younger patients (79% (n = 226), p = 0.72). Incomplete recovery (GOSE <8) was present in 43% (n = 69) of OA-mTBI, with 67% (n = 46) reporting good HRQoL. Two weeks post-injury, fewer OA-mTBI had (≥2) post-traumatic complaints compared to younger patients (68% vs. 80%, p = 0.01). In the multivariable analyses, only depression-related symptoms (OR = 1.20 for each symptom, 95% CI = 1.01–1.34, p < 0.01) were predictors of poor HRQoL in OA-mTBI. Conclusions: Similar to younger patients, most OA-mTBI rated their HRQoL as good at one year after injury, although a considerable proportion showed incomplete recovery according to the GOSE, suggesting a disability paradox. Depression-related symptoms emerged as a significant predictor for poor HRQoL and can be identified as an early target for treatment after mTBI. Full article
(This article belongs to the Special Issue Clinical Advances in Traumatic Brain Injury)
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21 pages, 4396 KiB  
Article
Screening Disinfection Byproducts in Arid-Coastal Wastewater: A Workflow Using GC×GC-TOFMS, Passive Sampling, and NMF Deconvolution Algorithm
by Muhammad Usman Siddiqui, Muhammad Sibtain, Farrukh Ahmad, Yasuyuki Zushi and Deedar Nabi
J. Xenobiot. 2024, 14(2), 554-574; https://doi.org/10.3390/jox14020033 (registering DOI) - 01 May 2024
Abstract
Disinfection during tertiary municipal wastewater treatment is a necessary step to control the spread of pathogens; unfortunately, it also gives rise to numerous disinfection byproducts (DBPs), only a few of which are regulated because of the analytical challenges associated with the vast number [...] Read more.
Disinfection during tertiary municipal wastewater treatment is a necessary step to control the spread of pathogens; unfortunately, it also gives rise to numerous disinfection byproducts (DBPs), only a few of which are regulated because of the analytical challenges associated with the vast number of potential DBPs. This study utilized polydimethylsiloxane (PDMS) passive samplers, comprehensive two-dimensional gas chromatography (GC×GC) coupled with time-of-flight mass spectrometry (TOFMS), and non-negative matrix factorization (NMF) spectral deconvolution for suspect screening of DBPs in treated wastewater. PDMS samplers were deployed upstream and downstream of the chlorination unit in a municipal wastewater treatment plant located in Abu Dhabi, and their extracts were analyzed using GC×GC-TOFMS. A workflow incorporating a multi-tiered, eight-filter screening process was developed, which successfully enabled the reliable isolation of 22 candidate DBPs from thousands of peaks. The NMF spectral deconvolution improved the match factor score of unknown mass spectra to the reference mass spectra available in the NIST library by 17% and facilitated the identification of seven additional DBPs. The close match of the first-dimension retention index data and the GC×GC elution patterns of DBPs, both predicted using the Abraham solvation model, with their respective experimental counterparts—with the measured data available in the NIST WebBook and the GC×GC elution patterns being those observed for the candidate peaks—significantly enhanced the accuracy of peak assignment. Isotopic pattern analysis revealed a close correspondence for 11 DBPs with clearly visible isotopologues in reference spectra, thereby further strengthening the confidence in the peak assignment of these DBPs. Brominated analogues were prevalent among the detected DBPs, possibly due to seawater intrusion. The fate, behavior, persistence, and toxicity of tentatively identified DBPs were assessed using EPI Suite™ and the CompTox Chemicals Dashboard. This revealed their significant toxicity to aquatic organisms, including developmental, mutagenic, and endocrine-disrupting effects in certain DBPs. Some DBPs also showed activity in various CompTox bioassays, implicating them in adverse molecular pathways. Additionally, 11 DBPs demonstrated high environmental persistence and resistance to biodegradation. This combined approach offers a powerful tool for future research and environmental monitoring, enabling accurate identification and assessment of DBPs and their potential risks. Full article
(This article belongs to the Section Emerging Chemicals)
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13 pages, 285 KiB  
Article
Metric Dimension of Circulant Graphs with 5 Consecutive Generators
by Martin Knor, Riste Škrekovski and Tomáš Vetrík
Mathematics 2024, 12(9), 1384; https://doi.org/10.3390/math12091384 (registering DOI) - 01 May 2024
Abstract
The problem of finding the metric dimension of circulant graphs with t generators 1,2,,t (and their inverses) has been extensively studied. The problem is solved for t=2,3,4, and some exact [...] Read more.
The problem of finding the metric dimension of circulant graphs with t generators 1,2,,t (and their inverses) has been extensively studied. The problem is solved for t=2,3,4, and some exact values and bounds are known also for t=5. We solve all the open cases for t=5. Full article
(This article belongs to the Special Issue Graph Theory and Applications, 2nd Edition)
18 pages, 344 KiB  
Article
Home Musical Activities Boost Premature Infants’ Language Development
by Fabia Franco, Maria Chifa and Nina Politimou
Children 2024, 11(5), 542; https://doi.org/10.3390/children11050542 (registering DOI) - 01 May 2024
Abstract
Infants born prematurely are considered at risk for language development delay and impairments. Using online parental reports, the present study investigated the influence of early musical experience in the home environment (Music@Home Infant Questionnaire) on language development (MacArthur–Bates Communicative Development Inventory) while controlling [...] Read more.
Infants born prematurely are considered at risk for language development delay and impairments. Using online parental reports, the present study investigated the influence of early musical experience in the home environment (Music@Home Infant Questionnaire) on language development (MacArthur–Bates Communicative Development Inventory) while controlling for general enrichment at home (Stim-Q Cognitive Home Environment Questionnaire) and perinatal post-traumatic stress disorder (Perinatal PTSD Questionnaire). Caregivers of 117 infants between 8 and 18 months of age (corrected age) without reported developmental difficulties completed an online survey. Results revealed that the musical home environment significantly predicted outcomes in reported infants’ receptive vocabulary and gestural communication, independently from infants’ corrected age and general enrichment of home activities. These findings constitute the first evidence that an enriched musical experience can enhance the development of early communication skills in a population at risk for language delays, namely infants born prematurely, opening the path for future intervention research in home and/or early childcare settings. Given that the majority of participants in this study were highly educated and from socioeconomically stable backgrounds, considerations regarding the generalizability of these results are discussed. Full article
12 pages, 245 KiB  
Article
Selectivity of the Premixtures Flufecanet, Diflufenican and Flufenacet, Diflufenican, Metribuzin on Bread Wheat (Triticum aestivum) and Barley (Hordeum vulgare) and Efficacy on ALS/ACCase-Resistant Populations of Lolium rigidum L.
by Thomas Gitsopoulos, Ioannis Georgoulas, Eirini Vazanelli and Despoina Botsoglou
Agronomy 2024, 14(5), 949; https://doi.org/10.3390/agronomy14050949 (registering DOI) - 01 May 2024
Abstract
The premixtures flufenacet plus diflufenican and flufenacet plus diflufenican plus metribuzin are two herbicides recently registered in Greece for weed control in bread wheat and barley with application early post-emergence to the crop (1st–3rd leaf growth stage). To evaluate the selectivity of these [...] Read more.
The premixtures flufenacet plus diflufenican and flufenacet plus diflufenican plus metribuzin are two herbicides recently registered in Greece for weed control in bread wheat and barley with application early post-emergence to the crop (1st–3rd leaf growth stage). To evaluate the selectivity of these new herbicides, pot experiments were conducted by applying flufenacet plus diflufenican at 240 + 120 g ai ha−1 and flufenacet plus diflufenican plus metribuzin at 119.7 + 119.7 + 44.8 g ai ha−1 to bread wheat and barley, at 1st (BBCH-11), 2nd (BBCH-12) and 3rd (BBCH-13) leaf growth stage. The efficacy of the herbicides at the above-mentioned rates in pre-emergence application was also tested on three ALS/ACCase herbicide-resistant populations of Lolium rigidum L. in comparison with the pre-emergence herbicides prosulfocarb and chlorotoluron plus diflufenican at 3200 g ai ha−1 and 1380 + 92 g ai ha−1, respectively. The results revealed decreased selectivity of both premixtures when applied at BBCH-11 for both winter cereals, with flufenacet plus diflufenican being less selective compared to flufenacet plus diflufenican plus metribuzin. Both herbicides highly controlled the three herbicide-resistant L. rigidum populations. The results indicated that both premixtures are effective chemical options for the management of herbicide resistant L. rigidum. To ensure crop safety and optimize efficacy, application at BBCH-12 is recommended. Full article
(This article belongs to the Special Issue Herbicides and Chemical Control of Weeds)
19 pages, 7408 KiB  
Review
Supernova Remnants in Gamma Rays
by Andrea Giuliani and Martina Cardillo
Universe 2024, 10(5), 203; https://doi.org/10.3390/universe10050203 (registering DOI) - 01 May 2024
Abstract
In the 1960s, the remnants of supernova explosions (SNRs) were indicated as a possible source of galactic cosmic rays through the Diffusive Shock Acceleration (DSA) mechanism. Since then, the observation of gamma-ray emission from relativistic ions in these objects has been one of [...] Read more.
In the 1960s, the remnants of supernova explosions (SNRs) were indicated as a possible source of galactic cosmic rays through the Diffusive Shock Acceleration (DSA) mechanism. Since then, the observation of gamma-ray emission from relativistic ions in these objects has been one of the main goals of high-energy astrophysics. A few dozen SNRs have been detected at GeV and TeV photon energies in the last two decades. However, these observations have shown a complex phenomenology that is not easy to reduce to the standard paradigm based on DSA acceleration. Although the understanding of these objects has greatly increased, and their nature as efficient electron and proton accelerators has been observed, it remains to be clarified whether these objects are the main contributors to galactic cosmic rays. Here, we review the observations of γ-ray emission from SNRs and the perspectives for the future. Full article
(This article belongs to the Special Issue Recent Advances in Gamma Ray Astrophysics and Future Perspectives)
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20 pages, 4039 KiB  
Article
Research on Mathematical Modeling of Critical Impact Force and Rollover Velocity of Coach Tripped Rollover Based on Numerical Analysis Method
by Xinye Wu, Zhiwei Wang and Shenghui Chen
Symmetry 2024, 16(5), 543; https://doi.org/10.3390/sym16050543 (registering DOI) - 01 May 2024
Abstract
Although the probability of a rollover accident is lower than that of other forms of collision, rollover is a serious accident that can break the symmetry of the vehicle and cause serious loss of life and property. There are many factors affecting rollovers, [...] Read more.
Although the probability of a rollover accident is lower than that of other forms of collision, rollover is a serious accident that can break the symmetry of the vehicle and cause serious loss of life and property. There are many factors affecting rollovers, such as the environment, the vehicle, and the driving control. A coach comprises a complex dynamic system; as such, the accuracy and rationality of the used mathematical model are decisive in the study of coach rollover warning and control. By analogy with the modeling method of an automobile collision accident, the general process of a coach rollover accident is analyzed in this study in combination with the contact form and freedom of motion characteristic of the coach body and external environment. According to the principle of conservation of energy, the mathematical models of critical rollover impact force in a collision between vehicles and obstacles and in a collision between two vehicles are established, allowing for analysis of the relationships between the critical tripped rollover impact forces required for a 90° rollover and the continuous action time and collision point height. During the collision between the vehicle and the obstacle, the occurrence of a vehicle rollover is related not only to the impact force in the collision process but also to the collision duration time. Even if the impact force is relatively small, the collision lasts long enough that a second collision may occur until the vehicle rolls over. In the process of a two-vehicle collision, the critical rollover impact force is not only related to the vehicle mass but also to the vehicle wheelbase and the height of the collision point. Based on the law of conservation of momentum, the mathematic models of 90-degree rollover and 180-degree rollover are established, and the critical rollover velocities are calculated. The purpose of this study is to provide reference and guidance for the research methods of vehicle rollover stability and anti-rollover control in the intelligent vehicle era. Full article
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26 pages, 11644 KiB  
Review
Textiles for Very Cold Environments
by Tomasz Blachowicz, Maciej Malczyk, Ilda Kola, Guido Ehrmann, Eva Schwenzfeier-Hellkamp and Andrea Ehrmann
Processes 2024, 12(5), 927; https://doi.org/10.3390/pr12050927 (registering DOI) - 01 May 2024
Abstract
Textiles are often used to protect people from cold environments. While most garments are designed for temperatures not far below 0 °C, very cold regions on the earth near the poles or on mountains necessitate special clothing. The same is true for homeless [...] Read more.
Textiles are often used to protect people from cold environments. While most garments are designed for temperatures not far below 0 °C, very cold regions on the earth near the poles or on mountains necessitate special clothing. The same is true for homeless people who have few possibilities to warm up or workers in cooling chambers and other cold environments. Passive insulating clothing, however, can only retain body heat. Active heating, on the other hand, necessitates energy, e.g., by batteries, which are usually relatively heavy and have to be recharged regularly. This review gives an overview of energy-self-sufficient textile solutions for cold environments, including energy harvesting by textile-based or textile-integrated solar cells; piezoelectric sensors in shoes and other possibilities; energy storage in supercapacitors or batteries; and heating by electric energy or phase-change materials. Full article
(This article belongs to the Special Issue Smart Wearable Technology: Thermal Management and Energy Applications)
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12 pages, 2081 KiB  
Article
Dynamics of Serum Inflammatory Markers and Adipokines in Patients: Implications for Monitoring Abnormal Body Weight: Preliminary Research
by Malwina Zimowska, Marta Rolbiecka, Klaudia Antoniak-Pietrynczak, Marta Jaskulak and Katarzyna Zorena
Metabolites 2024, 14(5), 260; https://doi.org/10.3390/metabo14050260 (registering DOI) - 01 May 2024
Abstract
This study aimed to investigate the influence of abnormal body weight on inflammatory markers and adipokine levels across varied body mass index (BMI) categories. The cohort included 46 participants categorized into normal BMI (group I; n = 19), overweight (group II; n = [...] Read more.
This study aimed to investigate the influence of abnormal body weight on inflammatory markers and adipokine levels across varied body mass index (BMI) categories. The cohort included 46 participants categorized into normal BMI (group I; n = 19), overweight (group II; n = 14), and obesity (group III; n = 13). Inflammatory markers (hsCRP and IL-6) and adipokines (Adiponectin, Leptin, Nesfatin-1, and Zinc-α2-glycoprotein) were assessed to discern effective indicators of inflammation in individuals with abnormal body weight. Additionally, the full lipid profile was also assessed (total cholesterol, triglycerides, LDL-C, HDL-C). The results indicated significant biochemical changes, particularly in IL-6 and Leptin levels, in participants with a BMI over 25. The levels of ZAG protein were negatively correlated with the HDL-C and LDC-L levels with statistical significance (Pearson: −0.57, p = 0.001, and Pearson: −0.41, p = 0.029, for HDL-C and LDL-C, respectively), suggesting that the level of ZAG is also inversely proportional to the amount of cholesterol. Statistical analyses revealed decreased Zinc-α2-glycoprotein (ZAG) levels and increased Adiponectin, Leptin, and IL-6 levels in individuals with abnormal body weight. Correlation analyses demonstrated a statistically significant upward trend for IL-6 (p = 0.0008) and Leptin (p = 0.00001), with a similar trend observed for hsCRP without statistical significance (p = 0.113). IL-6 levels in the overweight group were 158.71% higher than in the normal-weight group, while the obese group exhibited a 229.55% increase compared to the normal-weight group. No notable changes have been recorded for the levels of Nesfatin-1. Based on our results, we propose IL-6, Leptin, and ZAG as potential biomarkers for monitoring interventions and assessing patient conditions in those with abnormal BMIs. Further research with a larger patient cohort is warranted to validate these correlations in overweight and obese individuals. Full article
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12 pages, 235 KiB  
Article
The Application of a Synthetic Biodegradable Temporizing Matrix in Extensive Burn Injury: A Unicenter Experience of 175 Cases
by Christian Tapking, Adriana C. Panayi, Gabriel Hundeshagen, Benjamin F. Thomas, Emre Gazyakan, Bjoern Bliesener, Amir K. Bigdeli, Ulrich Kneser and Felix H. Vollbach
J. Clin. Med. 2024, 13(9), 2661; https://doi.org/10.3390/jcm13092661 (registering DOI) - 01 May 2024
Abstract
Objectives: Addressing extensive and deep burn wounds poses considerable challenges for both patients and surgeons. The NovoSorb® Biodegradable Temporizing Matrix (BTM) emerged as a novel dermal substitute and has been subjected to evaluation in large burn wound cases, with a specific [...] Read more.
Objectives: Addressing extensive and deep burn wounds poses considerable challenges for both patients and surgeons. The NovoSorb® Biodegradable Temporizing Matrix (BTM) emerged as a novel dermal substitute and has been subjected to evaluation in large burn wound cases, with a specific focus on identifying risk factors associated with suboptimal take rates. Methods: All patients with burn wounds greater than 10% body surface that underwent BTM treatment between March 2020 and November 2023 were eligible for inclusion. Univariate analyses and linear regression models were employed to discern risk factors and predictors influencing the take rates of both the BTM and split-thickness skin grafts (STSGs). Results: A total of 175 patients (mean age 56.2 ± 19.8 years, 70.3% male) were evaluated. The mean take rates of the BTM and STSGs were 82.0 ± 24.7% and 87.3 ± 19.0%, respectively. There were significant negative correlations between BTM take and the number of surgeries before BTM application (r = −0.19, p = 0.01), %TBSA and STSG take (r = −0.36, p = <0.001) and significant positive correlations between BTM and STSG take (r = 0.41, p ≤ 0.001) in addition to NPWT and STSG take (r = 0.21, p = 0.01). Multivariate regression analyses showed that a larger number of surgeries prior to BTM application (OR −3.41, 95% CI −6.82, −0.03, p = 0.04) was associated with poorer BTM take. Allograft treatment before BTM application (OR −14.7, 95% CI −23.0, −6.43,p = 0.01) and failed treatment with STSG before BTM application (OR −20.8, 95% CI −36.3, −5.23, p ≤ 0.01) were associated with poorer STSG take, whereas higher BTM take rates were associated with overall higher STSG take (OR −0.15, 95% 0.05, 0.26, p = 0.01). The Meek technique was used in 24 patients and showed similar take rates (BTM: 76.3 ± 28.0%, p = 0.22; STSG: 80.7 ± 21.1, p = 0.07). Conclusions: This study summarizes our findings on the application of a BTM in the context of large burn wounds. The results demonstrate that successful treatment can be achieved even in patients with extensive burns, resulting in satisfying take rates for both the BTM and STSG. The data underscore the importance of promptly applying a BTM to debrided wounds and indicate good results when using Meek. Full article
26 pages, 22269 KiB  
Article
Synthesis of Composite Sorbents with Chitosan and Varied Silica Phases for the Adsorption of Anionic Dyes
by Magdalena Blachnio, Malgorzata Zienkiewicz-Strzalka and Anna Derylo-Marczewska
Molecules 2024, 29(9), 2087; https://doi.org/10.3390/molecules29092087 (registering DOI) - 01 May 2024
Abstract
In this work, various types of silica materials were used for the synthesis of chitosan–silica composites. The composites were obtained using the chitosan (Ch) immobilization process from an aqueous solution on various silica phases, i.e., amorphous diatomite (ChAD), crystalline diatomite (ChCD), mesoporous silica [...] Read more.
In this work, various types of silica materials were used for the synthesis of chitosan–silica composites. The composites were obtained using the chitosan (Ch) immobilization process from an aqueous solution on various silica phases, i.e., amorphous diatomite (ChAD), crystalline diatomite (ChCD), mesoporous silica MCM-41 (ChMCM), and mesoporous silica SBA-15 (ChSBA). Textural, structural, morphological, and surface properties of the materials were determined by using various measurement techniques, i.e., low-temperature adsorption/desorption isotherms of nitrogen, X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), potentiometric titration, high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM). The adsorption properties towards various anionic dyes, i.e., acid red 88 (AR88), acid orange 8 (AO8), and orange G (OG), were evaluated based on kinetic and equilibrium measurements. The ChSBA, ChAD, and ChMCM composites were characterized by relatively high adsorption capacities (am) for AR88, with values equal to 0.78, 0.71, and 0.69 mmol/g, respectively. These composites were also distinguished by the rapid AR88 adsorption rate, with the values of half-time parameter t0.5 equal to 0.35, 2.84, and 1.53 min, respectively. The adsorption equilibrium and kinetic data were analyzed by applying the generalized Langmuir isotherm and the multi-exponential equation (m-exp), respectively. An interaction mechanism between the dyes and the obtained materials was proposed. Full article
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10 pages, 20028 KiB  
Article
UV/Ozone-Treated and Sol–Gel-Processed Y2O3 Insulators Prepared Using Gelation-Delaying Precursors
by Sangwoo Lee, Yoonjin Cho, Seongwon Heo, Jin-Hyuk Bae, In-Man Kang, Kwangeun Kim, Won-Yong Lee and Jaewon Jang
Nanomaterials 2024, 14(9), 791; https://doi.org/10.3390/nano14090791 (registering DOI) - 01 May 2024
Abstract
In this study, a Y2O3 insulator was fabricated via the sol–gel process and the effect of precursors and annealing processes on its electrical performance was studied. Yttrium(III) acetate hydrate, yttrium(III) nitrate tetrahydrate, yttrium isopropoxide oxide, and yttrium(III) tris (isopropoxide) were [...] Read more.
In this study, a Y2O3 insulator was fabricated via the sol–gel process and the effect of precursors and annealing processes on its electrical performance was studied. Yttrium(III) acetate hydrate, yttrium(III) nitrate tetrahydrate, yttrium isopropoxide oxide, and yttrium(III) tris (isopropoxide) were used as precursors, and UV/ozone treatment and high-temperature annealing were performed to obtain Y2O3 films from the precursors. The structure and surface morphologies of the films were characterized via grazing-incidence X-ray diffraction and scanning probe microscopy. Chemical component analysis was performed via X-ray spectroscopy. Electrical insulator characteristics were analyzed based on current density versus electrical field data and frequency-dependent dielectric constants. The Y2O3 films fabricated using the acetate precursor and subjected to the UV/ozone treatment showed a uniform and flat surface morphology with the lowest number of oxygen vacancy defects and unwanted byproducts. The corresponding fabricated capacitors showed the lowest current density (Jg) value of 10−8 A/cm2 at 1 MV/cm and a stable dielectric constant in a frequency range of 20 Hz–100 KHz. At 20 Hz, the dielectric constant was 12.28, which decreased to 10.5 at 105 Hz. The results indicate that high-quality, high-k insulators can be fabricated for flexible electronics using suitable precursors and the suggested low-temperature fabrication methods. Full article
(This article belongs to the Special Issue Nano-Structured Thin Films: Growth, Characteristics, and Application)
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16 pages, 19168 KiB  
Article
Enhanced Long-Term Corrosion Resistance of 316L Stainless Steel by Multilayer Amorphous Carbon Coatings
by Shuyu Li, Hao Li, Peng Guo, Xiaowei Li, Wei Yang, Guanshui Ma, Kazuhito Nishimura, Peiling Ke and Aiying Wang
Materials 2024, 17(9), 2129; https://doi.org/10.3390/ma17092129 (registering DOI) - 01 May 2024
Abstract
Diamond-like carbon (DLC) coatings are effective in protecting the key components of marine equipment and can greatly improve their short-term performance (1.5~4.5 h). However, the lack of investigation into their long-term (more than 200 h) performance cannot meet the service life requirements of [...] Read more.
Diamond-like carbon (DLC) coatings are effective in protecting the key components of marine equipment and can greatly improve their short-term performance (1.5~4.5 h). However, the lack of investigation into their long-term (more than 200 h) performance cannot meet the service life requirements of marine equipment. Here, three multilayered DLC coatings, namely Ti/DLC, TiCx/DLC, and Ti-TiCx/DLC, were prepared, and their long-term corrosion resistance was investigated. Results showed that the corrosion current density of all DLC coatings was reduced by 1–2 orders of magnitude compared with bare 316L stainless steel (316Lss). Moreover, under long-term (63 days) immersion in a 3.5 wt.% NaCl solution, all DLC coatings could provide excellent long-term corrosion protection for 316Lss, and Ti-TiCx/DLC depicted the best corrosion resistance; the polarization resistances remained at ~3.0 × 107 Ω·cm2 after immersion for 63 days, with more interfaces to hinder the penetration of the corrosive media. Meanwhile, during neutral salt spray (3000 h), the corrosion resistance of Ti/DLC and TiCx/DLC coatings showed a certain degree of improvement because the insoluble corrosion products at the defects blocked the subsequent corrosion. This study can provide a route to designing amorphous carbon protective coatings for long-term marine applications in different environments. Full article
(This article belongs to the Special Issue Friction, Corrosion and Protection of Material Surfaces)
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14 pages, 2300 KiB  
Article
Effect of Luting Materials on the Accuracy of Fit of Zirconia Copings: A Non-Destructive Digital Analysis Method
by Lara Berger, Ragai-Edward Matta, Christian Markus Weiß, Werner Adler, Manfred Wichmann and José Ignacio Zorzin
Materials 2024, 17(9), 2130; https://doi.org/10.3390/ma17092130 (registering DOI) - 01 May 2024
Abstract
The marginal accuracy of fit between prosthetic restorations and abutment teeth represents an essential aspect with regard to long-term clinical success. Since the final gap is also influenced by the luting techniques and materials applied, this study analyzed the accuracy of the fit [...] Read more.
The marginal accuracy of fit between prosthetic restorations and abutment teeth represents an essential aspect with regard to long-term clinical success. Since the final gap is also influenced by the luting techniques and materials applied, this study analyzed the accuracy of the fit of single-tooth zirconia copings before and after cementation using different luting materials. Forty plaster dies with a corresponding zirconia coping were manufactured based on a single tooth chamfer preparation. The copings were luted on the plaster dies (n = 10 per luting material) with a zinc phosphate (A), glass–ionomer (B), self-adhesive resin (C), or resin-modified glass–ionomer cement (D). The accuracy of fit for each coping was assessed using a non-destructive digital method. Intragroup statistical analysis was conducted using Wilcoxon signed rank tests and intergroup analysis by Kruskal–Wallis and Mann–Whitney U tests (α = 0.05). Accuracy of fit was significantly different before/after cementation within A (0.033/0.110 µm) and B (0.035/0.118 µm; p = 0.002). A had a significantly increased marginal gap compared to C and D, and B compared to C and D (p ≤ 0.001). Significantly increased vertical discrepancies between A and B versus C and D (p < 0.001) were assessed. Of the materials under investigation, the zinc phosphate cement led to increased vertical marginal discrepancies, whereas the self-adhesive resin cement did not influence the restoration fit. Full article
(This article belongs to the Special Issue Advanced Dental Materials: From Design to Application)
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16 pages, 3017 KiB  
Article
A Neoteric Feature Extraction Technique to Predict the Survival of Gastric Cancer Patients
by Warid Islam, Neman Abdoli, Tasfiq E. Alam, Meredith Jones, Bornface M. Mutembei, Feng Yan and Qinggong Tang
Diagnostics 2024, 14(9), 954; https://doi.org/10.3390/diagnostics14090954 (registering DOI) - 01 May 2024
Abstract
Background: At the time of cancer diagnosis, it is crucial to accurately classify malignant gastric tumors and the possibility that patients will survive. Objective: This study aims to investigate the feasibility of identifying and applying a new feature extraction technique to predict the [...] Read more.
Background: At the time of cancer diagnosis, it is crucial to accurately classify malignant gastric tumors and the possibility that patients will survive. Objective: This study aims to investigate the feasibility of identifying and applying a new feature extraction technique to predict the survival of gastric cancer patients. Methods: A retrospective dataset including the computed tomography (CT) images of 135 patients was assembled. Among them, 68 patients survived longer than three years. Several sets of radiomics features were extracted and were incorporated into a machine learning model, and their classification performance was characterized. To improve the classification performance, we further extracted another 27 texture and roughness parameters with 2484 superficial and spatial features to propose a new feature pool. This new feature set was added into the machine learning model and its performance was analyzed. To determine the best model for our experiment, Random Forest (RF) classifier, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and Naïve Bayes (NB) (four of the most popular machine learning models) were utilized. The models were trained and tested using the five-fold cross-validation method. Results: Using the area under ROC curve (AUC) as an evaluation index, the model that was generated using the new feature pool yields AUC = 0.98 ± 0.01, which was significantly higher than the models created using the traditional radiomics feature set (p < 0.04). RF classifier performed better than the other machine learning models. Conclusions: This study demonstrated that although radiomics features produced good classification performance, creating new feature sets significantly improved the model performance. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
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14 pages, 1557 KiB  
Article
Muscle Activation Frequency Relationship with Cost of Transport at Increasing Walking Speed in Preliminary Study Reveals Interplay of Both Active and Passive Dynamics
by Grace Van Namen, David Adair, Dean J Calsbeek and Rajat Emanuel Singh
Biomechanics 2024, 4(2), 269-282; https://doi.org/10.3390/biomechanics4020016 (registering DOI) - 01 May 2024
Abstract
Metabolic cost plays a critical role in gait biomechanics, particularly in rehabilitation. Several factors influence metabolic cost during walking. Therefore, this study aimed to examine the relationship between metabolic cost and muscle activity, focusing on the frequency of EMG signals during walking. We [...] Read more.
Metabolic cost plays a critical role in gait biomechanics, particularly in rehabilitation. Several factors influence metabolic cost during walking. Therefore, this study aimed to examine the relationship between metabolic cost and muscle activity, focusing on the frequency of EMG signals during walking. We recruited nine participants (five male and four female, age range 20–48 years) who walked for four minutes at six different speeds (ranging from 1.8 to 5.9 mph). EMG data were collected from the dominant lower leg muscles, specifically the lateral gastrocnemius (GAS-L) and the anterior tibialis (AT). Oxygen respiration was measured using open-circuit spirometry. Energy expenditure was estimated as the cost of transport (COT). The EMG data were analyzed using frequency domain features, such as the area under the curve of power spectral density (PSD-AUC) and the maximal distance between two points before and after the peak of the power spectral density curve (MDPSD). The results indicated that PSD-AUC is a better measure than MDPSD for understanding the relationship between activation frequency and COT. PSD-AUC demonstrated an increasing curvilinear trend (R2 = 0.93 and 0.77, second order polynomial fit), but the AT displayed higher variability. MDPSD exhibited more nonlinearity (R2 = 0.17–28, second order polynomial fit), but MDPSD demonstrated statistically significant differences (p < 0.05, t-test independent) in frequency between the GAS-L (64–237 Hz) and AT (114–287 Hz) during slow walking. Additionally, the relationship between COT and PSD-AUC revealed a U-shaped curve, suggesting that high COT is a function of both active and passive dynamics during walking. These findings will be valuable in rehabilitating individuals who suffer from gait-related disorders, especially those related to muscle inefficiency. Full article
(This article belongs to the Section Gait and Posture Biomechanics)
15 pages, 4402 KiB  
Article
Ligand- and Structure-Based Virtual Screening Identifies New Inhibitors of the Interaction of the SARS-CoV-2 Spike Protein with the ACE2 Host Receptor
by Timoteo Delgado-Maldonado, Alonzo González-González, Adriana Moreno-Rodríguez, Virgilio Bocanegra-García, Ana Verónica Martinez-Vazquez, Erick de Jesús de Luna-Santillana, Gerard Pujadas, Guadalupe Rojas-Verde, Edgar E. Lara-Ramírez and Gildardo Rivera
Pharmaceutics 2024, 16(5), 613; https://doi.org/10.3390/pharmaceutics16050613 (registering DOI) - 01 May 2024
Abstract
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast-spreading viral pathogen and poses a serious threat to human health. New SARS-CoV-2 variants have been arising worldwide; therefore, is necessary to explore more therapeutic options. The interaction of the viral spike (S) [...] Read more.
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast-spreading viral pathogen and poses a serious threat to human health. New SARS-CoV-2 variants have been arising worldwide; therefore, is necessary to explore more therapeutic options. The interaction of the viral spike (S) protein with the angiotensin-converting enzyme 2 (ACE2) host receptor is an attractive drug target to prevent the infection via the inhibition of virus cell entry. In this study, Ligand- and Structure-Based Virtual Screening (LBVS and SBVS) was performed to propose potential inhibitors capable of blocking the S receptor-binding domain (RBD) and ACE2 interaction. The best five lead compounds were confirmed as inhibitors through ELISA-based enzyme assays. The docking studies and molecular dynamic (MD) simulations of the selected compounds maintained the molecular interaction and stability (RMSD fluctuations less than 5 Å) with key residues of the S protein. The compounds DRI-1, DRI-2, DRI-3, DRI-4, and DRI-5 efficiently block the interaction between the SARS-CoV-2 spike protein and receptor ACE2 (from 69.90 to 99.65% of inhibition) at 50 µM. The most potent inhibitors were DRI-2 (IC50 = 8.8 µM) and DRI-3 (IC50 = 2.1 µM) and have an acceptable profile of cytotoxicity (CC50 > 90 µM). Therefore, these compounds could be good candidates for further SARS-CoV-2 preclinical experiments. Full article
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18 pages, 1670 KiB  
Article
Wilderness as Tourism Destination: Place Meanings and Preferences of Tourism Service Providers
by Anna Dóra Sæþórsdóttir and Edita Tverijonaite
Sustainability 2024, 16(9), 3807; https://doi.org/10.3390/su16093807 (registering DOI) - 01 May 2024
Abstract
The increase in wilderness use for nature-based tourism has complex implications for wilderness management. Tourism service providers play an important role in shaping tourism development trends, which can have an impact on wilderness. This stresses the importance of studying their perceptions and preferences [...] Read more.
The increase in wilderness use for nature-based tourism has complex implications for wilderness management. Tourism service providers play an important role in shaping tourism development trends, which can have an impact on wilderness. This stresses the importance of studying their perceptions and preferences regarding wilderness management. This study explores the meanings wilderness areas contain for tourism operators, the relationship of these meanings with wilderness management and development preferences, and the potential of place-based approaches to contribute to wilderness management. The study is based on 47 semi-structured interviews with tourism service providers offering services within or near the Icelandic Central Highlands, known for their vast, high-quality wilderness areas. The findings emphasize the importance of place meanings assigned by tourism service providers in shaping wilderness management preferences. The study highlights the usefulness of place-based management approaches, which can help identify potential conflicts between tourism and wilderness preservation, select proactive measures to minimize tourism’s impact on wilderness quality, and thereby facilitate sustainable tourism practices in wilderness. Full article
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11 pages, 2403 KiB  
Article
Facile Preparation of a Transparent, Self-Healing, and Recyclable Polysiloxane Elastomer Based on a Dynamic Imine and Boroxine Bond
by Peng Wang, Zhuochao Wang, Wenxin Cao and Jiaqi Zhu
Polymers 2024, 16(9), 1262; https://doi.org/10.3390/polym16091262 (registering DOI) - 01 May 2024
Abstract
Transparent polysiloxane elastomers with good self-healing and reprocessing abilities have attracted significant attention in the field of artificial skin and flexible displays. Herein, we propose a simple one-pot method to fabricate a room temperature self-healable polysiloxane elastomer (HPDMS) by introducing dynamic and reversible [...] Read more.
Transparent polysiloxane elastomers with good self-healing and reprocessing abilities have attracted significant attention in the field of artificial skin and flexible displays. Herein, we propose a simple one-pot method to fabricate a room temperature self-healable polysiloxane elastomer (HPDMS) by introducing dynamic and reversible imine bonds and boroxine into polydimethylsiloxane (PDMS) networks. The presence of imine bonds and boroxine is proved by FT−IR and NMR spectra. The obtained HPDMS elastomer is highly transparent with a transmittance of up to 80%. The TGA results demonstrated that the HPDMS elastomer has good heat resistance and can be used in a wide temperature range. A lower glass transition temperature (Tg, −127.4 °C) was obtained and revealed that the elastomer is highly flexible at room temperature. Because of the reformation of dynamic reversible imine bonds and boroxine, the HPDMS elastomers exhibited excellent autonomous self-healing properties. After healing for 3 h, the self-healing efficiency of HPDMS reached 96.3% at room temperature. Moreover, the elastomers can be repeatedly reprocessed multiple times under milder conditions. This work provides a simple but effective method to prepare transparent self-healable and reprocessable polysiloxane elastomers. Full article
(This article belongs to the Special Issue Advances in High-Performance Polymer Materials)
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14 pages, 2429 KiB  
Brief Report
Virological Traits of the SARS-CoV-2 BA.2.87.1 Lineage
by Lu Zhang, Alexandra Dopfer-Jablonka, Inga Nehlmeier, Amy Kempf, Luise Graichen, Noemí Calderón Hampel, Anne Cossmann, Metodi V. Stankov, Gema Morillas Ramos, Sebastian R. Schulz, Hans-Martin Jäck, Georg M. N. Behrens, Stefan Pöhlmann and Markus Hoffmann
Vaccines 2024, 12(5), 487; https://doi.org/10.3390/vaccines12050487 (registering DOI) - 01 May 2024
Abstract
Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be [...] Read more.
Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for efficient spread in the population. Full article
(This article belongs to the Special Issue New Trends in SARS-CoV-2 Variants and Vaccines)
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23 pages, 2064 KiB  
Article
Defining and Researching “Dynamic Systems of Systems”
by Rasmus Adler, Frank Elberzhager, Rodrigo Falcão and Julien Siebert
Software 2024, 3(2), 183-205; https://doi.org/10.3390/software3020009 (registering DOI) - 01 May 2024
Abstract
Digital transformation is advancing across industries, enabling products, processes, and business models that change the way we communicate, interact, and live. It radically influences the evolution of existing systems of systems (SoSs), such as mobility systems, production systems, energy systems, or cities, that [...] Read more.
Digital transformation is advancing across industries, enabling products, processes, and business models that change the way we communicate, interact, and live. It radically influences the evolution of existing systems of systems (SoSs), such as mobility systems, production systems, energy systems, or cities, that have grown over a long time. In this article, we discuss what this means for the future of software engineering based on the results of a research project called DynaSoS. We present the data collection methods we applied, including interviews, a literature review, and workshops. As one contribution, we propose a classification scheme for deriving and structuring research challenges and directions. The scheme comprises two dimensions: scope and characteristics. The scope motivates and structures the trend toward an increasingly connected world. The characteristics enhance and adapt established SoS characteristics in order to include novel aspects and to better align them with the structuring of research into different research areas or communities. As a second contribution, we present research challenges using the classification scheme. We have observed that a scheme puts research challenges into context, which is needed for interpreting them. Accordingly, we conclude that our proposals contribute to a common understanding and vision for engineering dynamic SoS. Full article
(This article belongs to the Topic Software Engineering and Applications)
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19 pages, 299 KiB  
Article
Meeting Stakeholder Needs: Who Should Managers Pay Close Attention To? Evidence from Listed Chinese Manufacturing Companies
by Isaiah Oino and Sina Yekini
Sustainability 2024, 16(9), 3806; https://doi.org/10.3390/su16093806 (registering DOI) - 01 May 2024
Abstract
Meeting the needs of stakeholders, as an element of CSR, requires a delicate balance of meeting these needs and ensuring profitability. Guided by the legitimacy theory and the stakeholder theory, this paper assesses the significance of meeting stakeholder needs and examines the types [...] Read more.
Meeting the needs of stakeholders, as an element of CSR, requires a delicate balance of meeting these needs and ensuring profitability. Guided by the legitimacy theory and the stakeholder theory, this paper assesses the significance of meeting stakeholder needs and examines the types of stakeholders that managers pay close attention to. Using a fixed-effects model on 859 Chinese manufacturing firms and a regression analysis, the results show a positive link between corporate social responsibility (CSR) activities and organisational financial performance via both accounting and market measures in the Chinese manufacturing market. Furthermore, the primary objective of companies is to maximise shareholder returns while also meeting societal needs. The results also indicate that responsibility to shareholders and employees and growth potential have significant positive impacts on a company’s market value. This research demonstrates the need for companies to engage in CSR activities, as this can establish an elevated level of financial performance. Furthermore, attention needs to be paid to other stakeholders in corporate CSR activities to engage them and sustain their commitments towards an organisation’s productivity, growth, and sustainability. This is the first study to examine the power of influence from different stakeholders using legitimacy theory. Secondly, it is the first study to evaluate this influence using the Chinese manufacturing industry, which is, arguably, one of the largest in its field. Full article

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