Abstract
TREATMENT of neonatal animals with nerve growth factor (NGF) promotes general growth and differentiation of the peripheral sympathetic nervous system. NGF markedly increases the outgrowth of axons and at the same time causes the appearance of many microtubules in electron-microscopic pictures1. Moreover, as a manifestation of enhanced differentiation NGF produces a selective induction of tyrosine hydroxylase (TH) and dopamine β-hydroxylase in sympathetic ganglia2. These two enzymes catalyse key steps in the biosynthesis of noradrenaline and are located selectively in adrenergic neurones3. In contrast, the third enzyme involved in the synthesis of noradrenaline, dopa decarboxylase (DDC), has a more general distribution and is not specifically regulated by NGF2.
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STÖCKEL, K., SOLOMON, F., PARAVICINI, U. et al. Dissociation between effects of nerve growth factor on tyrosine hydrolase and tubulin synthesis in sympathetic ganglia. Nature 250, 150–151 (1974). https://doi.org/10.1038/250150a0
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DOI: https://doi.org/10.1038/250150a0
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