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Differential function of major histocompatibility complex antigens in T-lymphocyte activation

Nature volume 259, pages 273–281 (1976)Cite this article

Abstract

The antigenic systems of the major histocompatibility complex can be subdivided into those which are serologically detectable and those which are detected in tests with mixed lymphocytes. The two systems have different roles in the activation of separate populations of T lymphocytes.

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References

  1. Bain, B., Vas, M. R., and Lowenstein, L., Blood, 23, 108–116 (1964).

    CAS  Google Scholar 

  2. Bach, F. H., and Hirschhorn, K., Science, 143, 813–814 (1964).

    Article  ADS  CAS  Google Scholar 

  3. Häyry, P., and Defendi, V., Science, 168, 133–135 (1970).

    Article  ADS  Google Scholar 

  4. Hodes, R. J., and Svedmyr, E. A. J., Transplantation, 9, 470–477 (1970).

    Article  CAS  Google Scholar 

  5. Solliday, S., and Bach, F. H., Science, 170, 1406–1409 (1970).

    Article  ADS  CAS  Google Scholar 

  6. Lightbody, J. J., Bernoco, D., Miggiano, V. C., and Ceppellini, R., G. Batt. Virol., 64, 273 (1971).

    Google Scholar 

  7. Bach, F. H., and Voynow, N. K., Science, 153, 545–547 (1966).

    Article  ADS  CAS  Google Scholar 

  8. Kasakura, S., and Lowentsein, L., Histocompatibility Testing 1965 (edit. by Amos, D. B., and van Rood, J. J.), 203–209 (Munksgaard, Copenhagen, 1965).

    Google Scholar 

  9. Wagner, H., Feldmann, M., Boyle, W., and Schrader, J. W., J. exp. Med., 136, 331–343 (1972).

    Article  CAS  Google Scholar 

  10. Häyry, P., Andersson, L. C., and Nordling, S., Transplant. Proc., 5, 87–90 (1973).

    PubMed  Google Scholar 

  11. Sondel, P. M., Chess, L., MacDermott, R. P., and Schlossman, S. F., J. Immun., 114, 982–987 (1975).

    CAS  PubMed  Google Scholar 

  12. Trinchiere, G., Bernoco, D., Curtini, S. E., Miggiano, V. C., and Ceppellini, R., Histocompatibility Testing 1972 (edit. by Colombani, J. and Dauseet, J.), 509–519 (Munksgaard, Copenhagen, 1972).

    Google Scholar 

  13. Shreffler, D. C., and David, C. S., Adv. Immuno., 20, 125–195 (1975).

    Article  CAS  Google Scholar 

  14. Meo, T., Vives, J., Miggiano, V., and Shreffler, D., Transplant. Proc., 5, 377–381 (1973).

    CAS  PubMed  Google Scholar 

  15. Bach, F. H., Widmer, M. B., Bach, M. L., and Klein, J., J. exp. Med., 136, 1430–1440 (1972).

    Article  CAS  Google Scholar 

  16. Bach, F. H., Widmer, M. B., Segall, M., Bach, M. L., and Klein, J., Science, 176, 1024–1027 (1972).

    Article  ADS  CAS  Google Scholar 

  17. David, C. S., Stimpfling, J. H., and Shreffler, D. C., Immunogenetics, 2, 131–139 (1975).

    Article  Google Scholar 

  18. Klein, J., Hauptfeld, M., and Hauptfeld, V., Immunogenetics, 1, 45–46 (1974).

    Article  Google Scholar 

  19. Armerding, D., Sachs, D. H., and Katz, D. H., J. exp. Med., 140, 1717–1722 (1974).

    Article  CAS  Google Scholar 

  20. Munro, A. J., and Taussig, M. J., Nature, 256, 103–105 (1975).

    Article  ADS  CAS  Google Scholar 

  21. Van Leeuwen, A., Schuit, J. J., and van Rood, J. J., Transplant. Proc., 5, 1539–1542 (1973).

    CAS  PubMed  Google Scholar 

  22. Winchester, R. J., et al., J. exp. Med., 141, 924–929 (1975).

    Article  CAS  Google Scholar 

  23. Bach, F. H., and van Rood, J. J., N. Engl. J. Med. (in the press).

  24. Bach, F. H., Bach, M. L., Alter, B. J., Lindhal, K. F., Schendel, D. J., and Sondel, P. M., Immune Recognition (edit. by Rosenthal, A. S.), 175–199 (Academic, New York, 1975).

    Google Scholar 

  25. Yunis, E. J., and Amos, D. B., Proc. natn. Acad. Sci. U.S.A., 68, 3031–3035 (1971).

    Article  ADS  CAS  Google Scholar 

  26. Eijsvoogel, V. P., et al., Histocompatibility Testing 1972 (edit. by Dausset, J. and Colombani, J.), 501–508 (Munksgaard, Copenhagen, 1972).

    Google Scholar 

  27. Widmer, M. B., Peck, A. B., and Bach, F. H., Transplant. Proc., 5, 1501–1505 (1973).

    CAS  PubMed  Google Scholar 

  28. Festenstein, H., Transplantation, 18, 555–557 (1974).

    Article  CAS  Google Scholar 

  29. Eijsvoogel, V. P., DuBois, R., Melief, C. J. M., and Kooy, L., Transplant. Proc., 5, 1301 (1973).

    CAS  PubMed  Google Scholar 

  30. Trinchieri, G., Bernoco, D., Curtoni, S. E., Miggiano, V. C., and Ceppellini, R., Histocompatibility Testing 1972 (edit. by Dausset, J., and Colombani, J.), 509–519 (Munksgaard, Copenhagen, 1972).

    Google Scholar 

  31. Alter, B. J., et al., J. exp. Med., 137, 1303–1309 (1973).

    Article  CAS  Google Scholar 

  32. Schendel, D. J., and Bach, F. H., J. exp. Med., 140, 1534–1546 (1974).

    Article  CAS  Google Scholar 

  33. Abbasi, K., et al., Transplant. Proc., 5, 1329–1337 (1973).

    CAS  PubMed  Google Scholar 

  34. Lindahl, K. F., and Bach, F. H., Nature, 254, 607–609 (1975).

    Article  ADS  CAS  Google Scholar 

  35. Schendel, D. J., Alter, B. J., and Bach, F. H., Transplant. Proc., 5, 1651–1655 (1973).

    CAS  PubMed  Google Scholar 

  36. Eijsvoogel, V. P., et al., Transplant. Proc., 5, 1675–1678 (1973).

    CAS  PubMed  Google Scholar 

  37. Peck, A. B., and Bach, F. H., Scand. J. Immun., 4, 53–62 (1975).

    Article  CAS  Google Scholar 

  38. Schendel, D. J., and Bach, F. H., Eur. J. Immun. (in the press).

  39. Bonnard, G. D., et al., Transplant. Proc., 5, 1679–1689 (1973).

    CAS  PubMed  Google Scholar 

  40. Cantor, H., and Asofsky, R., J. exp. Med., 135, 764–779 (1972).

    Article  CAS  Google Scholar 

  41. Bach, F. H., Transplant. Proc., 5, 23–29 (1973).

    CAS  PubMed  Google Scholar 

  42. Bach, F. H., et al., Science, 180, 403–406 (1973).

    Article  ADS  CAS  Google Scholar 

  43. Cantor, H., and Jandinski, J., J. exp. Med., 140, 1712–1716 (1974).

    Article  CAS  Google Scholar 

  44. Cantor, H., and Boyse, E. A., J. exp. Med., 141, 1376–1389 (1975).

    Article  CAS  Google Scholar 

  45. Cantor, H., and Boyse, E. A., J. exp. Med., 141, 1390–1399 (1975).

    Article  CAS  Google Scholar 

  46. Wagner, H., Röllinghoff, M., and Nosall, G. J. V., Transplant. Rev., 17, 3–36 (1973).

    CAS  PubMed  Google Scholar 

  47. Wagner, H., Röllinghoff, M., and Shortmann, K., Progress in Immunology II (edit. by Brent, L., and Holborow, J.), 111–120 (North Holland, Amsterdam, 1974).

    Google Scholar 

  48. Livnat, S., Klein, J., and Bach, F. H., Nature new Biol., 243, 42–44 (1973).

    CAS  PubMed  Google Scholar 

  49. Klein, J., and Park, J. M., J. exp. Med., 137, 1213–1225 (1974).

    Article  Google Scholar 

  50. Elkins, W. L., Kavathas, P., and Bach, F. H., Transplant. Proc., 5, 1759–1762 (1975).

    Google Scholar 

  51. Van Rood, J. J., Seminars in Hematology (edit. by Miescher, P. A., and Jaffe, E. R.), 253–262 (Grune and Stratton, New York, 1974).

    Google Scholar 

  52. Cochrum, K. C., Perkins, H. A., Payne, R. O., Kountz, S. L., and Belzer, F. O., Transplant. Proc., 5, 391–396 (1973).

    CAS  PubMed  Google Scholar 

  53. Segall, M., Bach, F. H., Bach, M. L., Hussey, J. L., and Uehling, D. T., Transplant. Proc., 7, (Suppl. 1), 41–43 (1975).

  54. Kissmeyer-Nielsen, F., et al., Lancet, ii, 662–664 (1966).

    Article  Google Scholar 

  55. Staines, N. A., and Davies, D. A. L., Histocompatibility Testing 1975 (edit. by Kissmeyer-Nielsen, F.) (Munksgaard, Copenhagen, in the press).

  56. Bretscher, P., and Cohn, M., Science, 169, 1042 (1970).

    Article  ADS  CAS  Google Scholar 

  57. Crichton, R., and Lafferty, J., Conference on Phylogeny, Hawaii, June, 1975, (in the press).

  58. Bach, F. H., Proc. of the 10th Leukocyte Culture Conference (in the press).

  59. Janis, M., Hartzman, R. J., and Bach, F. H., Histocompatibility Testing 1970 (edit. by Terasaki, P. I.), 509–515 (Munksgaard, Copenhagen, 1970).

    Google Scholar 

  60. Lindahl-Kiessling, K., and Safwenberg, J., Proc. of the VIth Leukocyte Culture Conference (edit. by Schwarz, R.), 623 (Academic, New York, 1971).

    Google Scholar 

  61. Klein, J., Hauptfeld, V., and Hauptfeld, M., Progress in Immunology II, 3, (edit. by Brent, L., and Holborow, J.), 197–206 (North Holland, Amsterdam, 1974).

    Google Scholar 

  62. Widmer, M. B., Alter, B. J., Bach, F. H., Bach, M. L., and Bailey, D. W., Nature new Biol., 242, 239–241 (1973).

    Article  CAS  Google Scholar 

  63. Bailey, D. W., Snell, G., and Cherry, M., Proc. of the Symp. on Immunogenetics of the H-2 System, Karger AG, Basel, Switzerland 155, (1971).

  64. Apt, A. S., Blandova, Z., Dishkant, I., Shumova, T., Verdernikov, A. A., and Egorov, I. K., Immunogenetics, 1, 444–451 (1975).

    Article  Google Scholar 

  65. Forman, J., and Klein, J., Immunogenetics, 1, 469–481 (1975).

    Article  Google Scholar 

  66. Segall, M., and Bach, F. H., Tissue Antigens, 6, 161–162 (1975).

    Article  CAS  Google Scholar 

  67. Nabholz, M., et al., Eur. J. Immun., 4, 378–387 (1974).

    Article  CAS  Google Scholar 

  68. Sondel, P. M., and Bach, F. H., J. exp. Med., 142, 1339–1348 (1975).

    Article  CAS  Google Scholar 

  69. Sondel, P. M., and Bach, F. H., Tissue Antigens (in the press).

  70. Lindahl, K. F., Peck, A. B., and Bach, F. H., Scand. J. Immun., 4, 541–553 (1975).

  71. Edidin, M., and Henney, C., Nature new Biol., 246, 47–49 (1973).

    Article  CAS  Google Scholar 

  72. Mawas, C., et al., Histocompatibility Testing 1975 (edit. by Kissmeyer-Nielsen, F.), (Munksgaard, Copenhagen, in the press).

  73. Meo, T., David, C. S., and Rijnbeek, A. M., Transplant. Proc. (in the press).

  74. Fathman, C. G., Handwerger, B. S., and Sach, D. H., J. exp. Med., 140, 853–858 (1974).

    Article  CAS  Google Scholar 

  75. van Rood, J. J., van Leeuwen, A., Parleuliet, K., Termitjelen, A., and Keuning, J. J., Histocompatibility Testing 1975 (edit. by Kissmeyer-Nielsen, F.) (Munks-gaard, Copenhagen, in the press).

  76. Boyse, E. A., and Old, L. J., A. Rev. Genet., 3, 269 (1969).

    Article  Google Scholar 

  77. Bodmer, W. F., Nature, 237, 139–145 (1972).

    Article  ADS  CAS  Google Scholar 

  78. Melvold, R. W., and Kohn, H. I., Mutat. Res., 27, 415–410 (1975).

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Authors and Affiliations

  1. Immunobiology Research Center and the Departments of Medical Genetics, Surgery and Pediatrics, The University of Wisconsin, Madison, 53706

    Fritz H. Bach, Marilyn L. Bach & Paul M. Sondel

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  1. Fritz H. Bach
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  2. Marilyn L. Bach
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  3. Paul M. Sondel
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Bach, F., Bach, M. & Sondel, P. Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature 259, 273–281 (1976). https://doi.org/10.1038/259273a0

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