Abstract
A WIDE range of membrane anomalies is one of the characteristics of dystrophic muscle1,2. Since prostaglandins (PGs) are known to interact with such membrane constituents as adenyl and guanyl cyclase; Mg2+-dependent, Na+/K+-activated ATPase; Mg2+-dependent, Ca2+-activated ATPase; adenylate kinase; and phosphodiesterase3, it seemed desirable to search for a possible relationship between PGs and the dystrophic condition. The activities of two potentially regulatory PG-metabolising enzymes were measured. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activities4 in the breast muscles of 10-d post-hatching chicks with hereditary muscular dystrophy (New Hampshire strain) and the breast muscles of 10-d post-hatching normal (white leghorn) chicks were the same as those in the leg muscles of these animals. PGE 9-ketoreductase activity5,6 in the dystrophic breast muscle was considerably more active than its control (normal) breast muscle. Subsequently, it was found that the normal breast muscle contains a much higher level of an inhibitor of PGE 9-ketoreductase activity than dystrophic breast muscle.
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References
Rodan, S. B., Hintz, R. L., Sha'afi, R. I., and Rodan, G. A., Nature, 252, 589–591 (1974).
Roses, A. D., Herbstreith, M. H., and Appel, S. H., Nature, 254, 350–351 (1975).
Ramwell, P. W., and Kury, P., in Prostaglandins 1973, 43–54 (INSERM, Paris, 1973).
Anggard, E., and Samuelsson, B., Ark. Kemi., 25, 293–300 (1966).
Lee, S. C., and Levine, L., J. biol. Chem., 249, 1369–1375 (1974); Lee, S. C., and Levine, L., J. biol. Chem., 250, 4549–4555 (1975).
Hensby, C. N., Biochim. biophys. Acta, 348, 145–154 (1974).
Milhorat, A. T. (ed.), Exploratory Concepts in Muscular Dystrophy and Related Disorders (Excerpta Medica Foundation, International Congress Series No. 147, 1967); Exploratory Concepts in Muscular Dystrophy II (Excerpta Medica Foundation, International Congress Series No. 333, Amsterdam, American Elsevier, New York, 1974).
Cosmos, E., Devl Biol., 13, 163–181 (1966).
Pace-Asciak, C., and Miller, D., Prostaglandins, 4, 351–362 (1973).
Pace-Asciak, C., J. biol. Chem., 250, 2789–2794 (1975); Pace-Asciak, C., J. biol. Chem., 250, 2795–2800 (1975).
West, W. T., in Man and Animals (edit. by Bourne, G. H., and Golarz, M. N.), 367 (Hafner, New York, 1967).
Zalkin, H., et al., J. biol. Chem., 237, 2678–2682 (1962).
Chow, T., et al., J. clin. Invest., 56, 842–849 (1975).
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LEVINE, L., Wu, KY. & HERRMANN, H. Decreased levels of an inhibitor of prostaglandin E 9-ketoreductase activity in chick dystrophic breast muscle. Nature 260, 791–793 (1976). https://doi.org/10.1038/260791a0
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DOI: https://doi.org/10.1038/260791a0
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