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Toxicity of Poly I.Poly C for Rabbit Eyes

Nature volume 228, pages 362–364 (1970)Cite this article

Abstract

A SYNTHETIC polyriboinosinic acid.polyribocytidylic acid complex (poly I.poly C) is known to be a potent inducer of interferon1 and to mediate resistance to various viral and nonviral infections in vivo and in vitro. Recently poly I.poly C was reported to be effective in herpetic keratitis in rabbits without producing any evidence of local or systemic toxicity2. While studying the effects of intravenous poly I.poly C on herpetic kerato-uveitis in rabbits, however, we noticed ocular changes in many animals and here describe the ocular toxicity in rabbits which received only intravenous poly I.poly C.

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Author notes

  1. W. LAURENCE BURT

    Present address: Department of Ophthalmology, Victoria Hospital, London, Ontario

Authors and Affiliations

  1. Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco, San Francisco, California, 94122

    H. BRUCE OSTLER, JANG O. OH, CHANDLER R. DAWSON & W. LAURENCE BURT

Authors
  1. H. BRUCE OSTLER
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  2. JANG O. OH
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  3. CHANDLER R. DAWSON
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  4. W. LAURENCE BURT
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OSTLER, H., OH, J., DAWSON, C. et al. Toxicity of Poly I.Poly C for Rabbit Eyes. Nature 228, 362–364 (1970). https://doi.org/10.1038/228362a0

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  • DOI: https://doi.org/10.1038/228362a0

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