Abstract
Irradiated lymphoma cells markedly activate human lymphocytes in a mixed cell reaction. HeLa cells (irradiated or disrupted), high concentrations of allogeneic erythrocytes, disrupted leucocytes or microsome preparations from spleen are all inactive. Does the mixed lymphocyte reaction require two populations of viable lymphoid cells ?
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HARDY, D., LING, N. Effects of some Cellular Antigens on Lymphocytes and the Nature of the Mixed Lymphocyte Reaction. Nature 221, 545–548 (1969). https://doi.org/10.1038/221545a0
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DOI: https://doi.org/10.1038/221545a0
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