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Malignant Transformation by Rauscher Strain Murine Leukaemia Virus

Nature volume 214, pages 815–817 (1967)Cite this article

Abstract

MORPHOLOGICAL transformation by Moloney virus1 and by Friend virus2 has been reported in mouse cells. The induction of sarcomas in newborn mice by the Moloney strain of murine leukaemia virus3,4 and by Friend virus-transformed mouse embryo cells2 has also been described. Rauscher murine leukaemia virus5 can be propagated in rat kidney cell line called NCI–ER (ref. 6). The present communication describes morphological alterations observed in cell cultures derived from Rauscher leukaemic rats and the neoplastic lesions induced by these altered cells in infant rats.

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Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland

    H. DUC-NGUYEN, E. N. ROSENBLUM, N. A. WIVEL & M. V. A. SMITH

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  1. H. DUC-NGUYEN
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  2. E. N. ROSENBLUM
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  3. N. A. WIVEL
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  4. M. V. A. SMITH
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DUC-NGUYEN, H., ROSENBLUM, E., WIVEL, N. et al. Malignant Transformation by Rauscher Strain Murine Leukaemia Virus. Nature 214, 815–817 (1967). https://doi.org/10.1038/214815a0

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  • DOI: https://doi.org/10.1038/214815a0

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