Abstract
SLICES of adult rat kidney have been found not to take up oxygen at a constant rate in media which are suitable for other tissues1,2. They were found to do so, however, in a medium containing physiological concentrations of sodium, potassium, calcium, magnesium, phosphate and chloride ions and glucose3. Because its ionic requirements are so critical, this was considered a suitable tissue to use in an investigation of the relative importance of the cations and anions in balanced media. Slices of adult rat kidney were therefore set up in Barcroft manometers under oxygen at 38.5° C. in media having the cation concentrations which had been found to support their steady respiration, but in which chloride was replaced by other anions.
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References
Laser, H., Biochem. J., 36, 319 (1942).
Cutting, M., and McCance, R. A., J. Physiol., 104, 288 (1946).
Robinson, J. R., Biochem. J., 45, 68 (1949).
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ROBINSON, J. Effect of Anions on the Respiration of Kidney Slices from Adult Rats. Nature 165, 730–731 (1950). https://doi.org/10.1038/165730b0
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DOI: https://doi.org/10.1038/165730b0
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